Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	858	12p13	USP5	ubiquitin specific peptidase 5
Mouse	-	858	6 59.17 cM	Usp5	ubiquitin specific peptidase 5 (isopeptidase T)
Rat	-	858	4q42	Usp5	ubiquitin specific peptidase 5

Previous and Unofficial Names

deubiquitinating enzyme 5 | IsoT | ubiquitin carboxy terminal hydrolase T | ubiquitin carboxyl-terminal hydrolase 5 | ubiquitin specific protease 5 | ubiquitin thioesterase 5 | ubiquitin thiolesterase 5 | Ucht | ubiquitin specific peptidase 5 (isopeptidase T)

Database Links
Specialist databases
MEROPS	C19.001 (Hs)
Other databases
Alphafold	P45974 (Hs), P56399 (Mm)
BRENDA	3.4.19.12
CATH/Gene3D	3.30.40.10
ChEMBL Target	CHEMBL6158 (Hs)
Ensembl Gene	ENSG00000111667 (Hs), ENSMUSG00000038429 (Mm), ENSRNOG00000015409 (Rn)
Entrez Gene	8078 (Hs), 22225 (Mm), 297593 (Rn)
Human Protein Atlas	ENSG00000111667 (Hs)
KEGG Enzyme	3.4.19.12
KEGG Gene	hsa:8078 (Hs), mmu:22225 (Mm), rno:297593 (Rn)
OMIM	601447 (Hs)
Pharos	P45974 (Hs)
RefSeq Nucleotide	NM_003481 (Hs), NM_001098536 (Hs), NM_013700 (Mm), NM_001106619 (Rn)
RefSeq Protein	NP_001092006 (Hs), NP_003472 (Hs), NP_038728 (Mm), NP_001100089 (Rn)
UniProtKB	P45974 (Hs), P56399 (Mm)
Wikipedia	USP5 (Hs)

Enzyme Reaction
EC Number: 3.4.19.12

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference vialinin A Hs Inhibition 5.4 pKi 1 ⤷ pKi 5.4 (Ki 4x10-6 M) [1]