[125I][Tyr26]galanin (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
9.5 – 9.9
|
pKd
|
6,17
|
|
⤷ |
pKd
9.9
(Kd 1.2x10-10 M)
[17]
pKd
9.5
(Kd 3.1x10-10 M)
[6]
|
[125I][Tyr26]galanin (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
9.5 – 9.6
|
pKd
|
5,26
|
|
⤷ |
pKd
9.5 – 9.6
(Kd 3.1x10-10 – 2.4x10-10 M)
[5,26]
|
[125I][Tyr26]galanin (human)
|
|
|
|
|
|
|
|
|
|
|
Mm |
Agonist |
9.3
|
pKd
|
42
|
|
⤷ |
pKd
9.3
(Kd 4.7x10-10 M)
[42]
|
[125I][Tyr26]galanin (human)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
9.2
|
pKd
|
61
|
|
⤷ |
pKd
9.2
(Kd 5.9x10-10 M)
[61]
|
[125I][Tyr26]galanin (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.4 – 9.9
|
pKd
|
12,18,54,61
|
|
⤷ |
pKd
8.4 – 9.9
(Kd 4x10-9 – 1.3x10-10 M)
[12,18,54,61]
|
galmic
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<5.0
|
pKd
|
3,33
|
|
⤷ |
pKd
<5.0
(Kd >1x10-5 M)
[3,33]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
9.1
|
pKi
|
53
|
|
⤷ |
pKi
9.1
(Ki 7x10-10 M)
[53]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
9.0 – 9.3
|
pKi
|
53-54
|
|
⤷ |
pKi
9.0 – 9.3
(Ki 1.05x10-9 – 5x10-10 M)
[53-54]
|
galanin(1-20) (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
9.1
|
pKi
|
5
|
|
⤷ |
pKi
9.1
(Ki 7.8x10-10 M)
[5]
|
galanin(2-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
9.0
|
pKi
|
5
|
|
⤷ |
pKi
9.0
(Ki 9.1x10-10 M)
[5]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
9.0
|
pKi
|
6
|
|
⤷ |
pKi
9.0
(Ki 9.5x10-10 M)
[6]
|
galanin
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.6 – 9.1
|
pKi
|
5-6,48
|
|
⤷ |
pKi
8.6 – 9.1
(Ki 2.34x10-9 – 8.6x10-10 M)
[5-6,48]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.3 – 9.3
|
pKi
|
33,42,54,60-62
|
|
⤷ |
pKi
8.3 – 9.3
(Ki 5.6x10-9 – 5.6x10-10 M)
[33,42,54,60-62]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.5 – 8.8
|
pKi
|
5-6,36,44,47,55
|
|
⤷ |
pKi
8.5 – 8.8
(Ki 2.98x10-9 – 1.54x10-9 M)
[5-6,36,44,47,55]
|
galanin
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.6
|
pKi
|
54
|
|
⤷ |
pKi
8.6
(Ki 2.51x10-9 M)
[54]
|
galanin(7-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.6
|
pKi
|
5
|
|
⤷ |
pKi
8.6
(Ki 2.51x10-9 M)
[5]
|
galanin(2-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.5
|
pKi
|
6
|
|
⤷ |
pKi
8.5
(Ki 2.88x10-9 M)
[6]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.5
|
pKi
|
5
|
|
⤷ |
pKi
8.5
(Ki 3.5x10-9 M)
[5]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Mm |
Full agonist |
8.4
|
pKi
|
42
|
|
⤷ |
pKi
8.4
(Ki 3.9x10-9 M)
[42]
|
galanin(2-30) (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.0 – 8.7
|
pKi
|
5,11
|
|
⤷ |
pKi
8.0 – 8.7
(Ki 1x10-8 – 1.8x10-9 M)
[5,11]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.9 – 8.8
|
pKi
|
5-6,8
|
|
⤷ |
pKi
7.9 – 8.8
(Ki 1.3x10-8 – 1.6x10-9 M)
[5-6,8]
|
galanin(1-19) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.3
|
pKi
|
62
|
|
⤷ |
pKi
8.3
(Ki 4.7x10-9 M)
[62]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.9 – 8.7
|
pKi
|
42,53-54,60-62
|
|
⤷ |
pKi
7.9 – 8.7
(Ki 1.3x10-8 – 1.8x10-9 M)
[42,53-54,60-62]
|
J20 (galanin analogue)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.3
|
pKi
|
45
|
|
⤷ |
pKi
8.3
(Ki 4.9x10-9 M)
[45]
|
galanin(7-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.3
|
pKi
|
6
|
|
⤷ |
pKi
8.3
(Ki 4.9x10-9 M)
[6]
|
M1153
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.3
|
pKi
|
47
|
|
⤷ |
pKi
8.3
(Ki 4.98x10-9 M)
[47]
|
M617
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.2
|
pKi
|
36
|
|
⤷ |
pKi
8.2
(Ki 5.71x10-9 M)
[36]
|
M242
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.2
|
pKi
|
48
|
|
⤷ |
pKi
8.2
(Ki 5.84x10-9 M)
[48]
|
galanin(1-12)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.2
|
pKi
|
5
|
|
⤷ |
pKi
8.2
(Ki 6.4x10-9 M)
[5]
|
M1145
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.2
|
pKi
|
44
|
|
⤷ |
pKi
8.2
(Ki 6.55x10-9 M)
[44]
|
galanin(2-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Mm |
Full agonist |
8.2
|
pKi
|
42
|
|
⤷ |
pKi
8.2
(Ki 6.8x10-9 M)
[42]
|
[D-Trp2]galanin-(1-29)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.1
|
pKi
|
53
|
|
⤷ |
pKi
8.1
(Ki 7x10-9 M)
[53]
|
galanin(2-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
7.3 – 8.7
|
pKi
|
42,60-62
|
|
⤷ |
pKi
7.3 – 8.7
(Ki 5.6x10-8 – 1.9x10-9 M)
[42,60-62]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Mm |
Agonist |
7.9
|
pKi
|
42
|
|
⤷ |
pKi
7.9
(Ki 1.18x10-8 M)
[42]
|
Gal-B2-dPEG24
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.9
|
pKi
|
69
|
|
⤷ |
pKi
7.9
(Ki 1.35x10-8 M)
[69]
|
galanin(D-Trp2) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.6 – 8.1
|
pKi
|
53-54
|
|
⤷ |
pKi
7.6 – 8.1
(Ki 2.754x10-8 – 7x10-9 M)
[53-54]
|
Gal-B2-C10
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pKi
|
70
|
|
⤷ |
pKi
7.8
(Ki 1.44x10-8 M)
[70]
|
Gal-B2-C8
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pKi
|
70
|
|
⤷ |
pKi
7.8
(Ki 1.49x10-8 M)
[70]
|
Gal-B2-C18
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pKi
|
70
|
|
⤷ |
pKi
7.8
(Ki 1.5x10-8 M)
[70]
|
Gal-B2-C12
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pKi
|
70
|
|
⤷ |
pKi
7.8
(Ki 1.61x10-8 M)
[70]
|
galanin(2-11)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pKi
|
44
|
|
⤷ |
pKi
7.8
(Ki 1.66x10-8 M)
[44]
|
Gal-B2-C14
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.7
|
pKi
|
70
|
|
⤷ |
pKi
7.7
(Ki 1.82x10-8 M)
[70]
|
J18 (galanin analogue)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.7
|
pKi
|
45
|
|
⤷ |
pKi
7.7
(Ki 2x10-8 M)
[45]
|
[N-Me,des-Sar]Gal-B2
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.7
|
pKi
|
43
|
|
⤷ |
pKi
7.7
(Ki 2.02x10-8 M)
[43]
|
Gal-B2-MPEG4
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.7
|
pKi
|
70
|
|
⤷ |
pKi
7.7
(Ki 2.05x10-8 M)
[70]
|
Gal-(K)4
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.6
|
pKi
|
70
|
|
⤷ |
pKi
7.6
(Ki 2.4x10-8 M)
[70]
|
M1151
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.5
|
pKi
|
47
|
|
⤷ |
pKi
7.5
(Ki 2.89x10-8 M)
[47]
|
M1160
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.5
|
pKi
|
46
|
|
⤷ |
pKi
7.5
(Ki 3.33x10-8 M)
[46]
|
M1152
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.4
|
pKi
|
47
|
|
⤷ |
pKi
7.4
(Ki 3.64x10-8 M)
[47]
|
Gal-B5
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.3
|
pKi
|
8
|
|
⤷ |
pKi
7.3
(Ki 4.8x10-8 M)
[8]
|
Gal-B2
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.3
|
pKi
|
8
|
|
⤷ |
pKi
7.3
(Ki 5.15x10-8 M)
[8]
|
Gal-R2-dPEG24
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.2
|
pKi
|
69
|
|
⤷ |
pKi
7.2
(Ki 6.04x10-8 M)
[69]
|
galanin(2-11)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.1
|
pKi
|
32
|
|
⤷ |
pKi
7.1
(Ki 8.8x10-8 M)
[32]
|
galanin(D-Trp2) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
6.7
|
pKi
|
6
|
|
⤷ |
pKi
6.7
(Ki 1.995x10-7 M)
[6]
|
galanin(3-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(10-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(5-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(9-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(9-25) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(3-30) (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
galanin(1-10)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.2
|
pKi
|
5
|
|
⤷ |
pKi
<6.2
(Ki >7x10-7 M)
[5]
|
GMAP(1-41)
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.1
|
pKi
|
61
|
|
⤷ |
pKi
<6.1
(Ki >8.4x10-7 M)
[61]
|
galanin(3-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.0
|
pKi
|
6
|
|
⤷ |
pKi
<6.0
(Ki >1x10-6 M)
[6]
|
galanin(3-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.0
|
pKi
|
53-54
|
|
⤷ |
pKi
<6.0
(Ki >1x10-6 M)
[53-54]
|
GMAP(44-59)
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.0
|
pKi
|
62
|
|
⤷ |
pKi
<6.0
(Ki >1x10-6 M)
[62]
|
(D-Thr6, D-Trp8,9)galanin(1-15)ol
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<5.9
|
pKi
|
61
|
|
⤷ |
pKi
<5.9
(Ki >1.25x10-6 M)
[61]
|
galanin(3-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
5.5 – 6.0
|
pKi
|
42,60,62
|
|
⤷ |
pKi
5.5 – 6.0
(Ki 3.125x10-6 – 1x10-6 M)
[42,60,62]
|
galanin(10-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Mm |
Agonist |
<5.7
|
pKi
|
42
|
|
⤷ |
pKi
<5.7
(Ki >1.86x10-6 M)
[42]
|
galanin(3-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Mm |
Agonist |
<5.7
|
pKi
|
42
|
|
⤷ |
pKi
<5.7
(Ki >2.2x10-6 M)
[42]
|
galnon
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
4.5
|
pKi
|
3,33
|
|
⤷ |
pKi
4.5
(Ki 3.41x10-5 M)
[3,33]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
9.1
|
pEC50
|
17
|
|
⤷ |
pEC50
9.1
(EC50 7.2x10-10 M)
[17]
|
galanin-like peptide
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.6
|
pEC50
|
41
|
|
⤷ |
pEC50
8.6
(EC50 2.4x10-9 M)
[41]
|
galanin
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
7.9 – 9.1
|
pEC50
|
6,17
|
|
⤷ |
pEC50
7.9 – 9.1
(EC50 1.23x10-8 – 7.1x10-10 M)
[6,17]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.3 – 9.4
|
pEC50
|
6,17
|
|
⤷ |
pEC50
7.3 – 9.4
(EC50 5.495x10-8 – 4.2x10-10 M)
[6,17]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.3
|
pEC50
|
41
|
|
⤷ |
pEC50
8.3
(EC50 5.2x10-9 M)
[41]
|
galanin(2-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
7.6 – 8.9
|
pEC50
|
6,17
|
|
⤷ |
pEC50
7.6 – 8.9
(EC50 2.399x10-8 – 1.17x10-9 M)
[6,17]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.1
|
pEC50
|
6
|
|
⤷ |
pEC50
8.1
(EC50 8.12x10-9 M)
[6]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
7.7
|
pEC50
|
53
|
|
⤷ |
pEC50
7.7
(EC50 1.8x10-8 M)
[53]
|
galanin(7-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.5
|
pEC50
|
6
|
|
⤷ |
pEC50
7.5
(EC50 3.467x10-8 M)
[6]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.2
|
pEC50
|
53
|
|
⤷ |
pEC50
7.2
(EC50 6.5x10-8 M)
[53]
|
Qu-SPX
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.1
|
pEC50
|
30
|
|
⤷ |
pEC50
7.1
(EC50 8.71x10-8 M)
[30]
Description: SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL3 receptor.
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.0
|
pEC50
|
53
|
|
⤷ |
pEC50
7.0
(EC50 9.4x10-8 M)
[53]
|
galanin(D-Trp2) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
6.8
|
pEC50
|
53
|
|
⤷ |
pEC50
6.8
(EC50 1.5x10-7 M)
[53]
|
spexin-1
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
6.8
|
pEC50
|
25
|
|
⤷ |
pEC50
6.8
(EC50 1.61x10-7 M)
[25]
Description: Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2.
|
galanin(D-Trp2) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
6.5
|
pEC50
|
6
|
|
⤷ |
pEC50
6.5
(EC50 3.388x10-7 M)
[6]
|
galanin(3-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.0
|
pEC50
|
6
|
|
⤷ |
pEC50
<6.0
(EC50 >1x10-6 M)
[6]
|
galanin(3-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.0
|
pEC50
|
53
|
|
⤷ |
pEC50
<6.0
(EC50 >1x10-6 M)
[53]
|
galanin(10-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.0
|
pEC50
|
17
|
|
⤷ |
pEC50
<6.0
(EC50 >1x10-6 M)
[17]
|
galanin-like peptide
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
9.6
|
pIC50
|
41
|
|
⤷ |
pIC50
9.6
(IC50 2.4x10-10 M)
[41]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
9.5
|
pIC50
|
17
|
|
⤷ |
pIC50
9.5
(IC50 3.5x10-10 M)
[17]
|
galanin
{Sp: Pig}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
9.3 – 9.4
|
pIC50
|
18,22
|
|
⤷ |
pIC50
9.3 – 9.4
(IC50 4.6x10-10 – 3.7x10-10 M)
[18,22]
|
galanin
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
9.3
|
pIC50
|
17
|
|
⤷ |
pIC50
9.3
(IC50 5.1x10-10 M)
[17]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.7 – 9.3
|
pIC50
|
7,18,41
|
|
⤷ |
pIC50
8.7 – 9.3
(IC50 1.9x10-9 – 4.8x10-10 M)
[7,18,41]
|
galanin
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.6 – 9.0
|
pIC50
|
18,22,31
|
|
⤷ |
pIC50
8.6 – 9.0
(IC50 2.5x10-9 – 1x10-9 M)
[18,22,31]
|
galanin(1-11)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.8
|
pIC50
|
31
|
|
⤷ |
pIC50
8.8
(IC50 1.65x10-9 M)
[31]
|
[Sar1, D-Ala12]galanin(1-16)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.8
|
pIC50
|
31
|
|
⤷ |
pIC50
8.8
(IC50 1.74x10-9 M)
[31]
|
galanin(2-11)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.8
|
pIC50
|
31
|
|
⤷ |
pIC50
8.8
(IC50 1.76x10-9 M)
[31]
|
galanin(2-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
8.7 – 8.7
|
pIC50
|
17-18
|
|
⤷ |
pIC50
8.7 – 8.7
(IC50 1.87x10-9 – 1.8x10-9 M)
[17-18]
|
galanin
{Sp: Mouse, Rat}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Full agonist |
7.9 – 9.5
|
pIC50
|
6,17
|
|
⤷ |
pIC50
9.5
(IC50 3.4x10-10 M)
[17]
pIC50
7.9 – 9.1
(IC50 1.175x10-8 – 7.6x10-10 M)
[6,17]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.7
|
pIC50
|
17
|
|
⤷ |
pIC50
8.7
(IC50 2.17x10-9 M)
[17]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
8.6
|
pIC50
|
17
|
|
⤷ |
pIC50
8.6
(IC50 2.47x10-9 M)
[17]
|
galanin(2-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Full agonist |
8.5
|
pIC50
|
22
|
|
⤷ |
pIC50
8.5
(IC50 2.9x10-9 M)
[22]
|
galanin(1-16) (rat/mouse/pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
7.9 – 8.5
|
pIC50
|
18,22
|
|
⤷ |
pIC50
7.9 – 8.5
(IC50 1.32x10-8 – 3x10-9 M)
[18,22]
|
galanin(1-15)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
8.1
|
pIC50
|
18
|
|
⤷ |
pIC50
8.1
(IC50 7.4x10-9 M)
[18]
|
GALP(3-32) (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.8
|
pIC50
|
27
|
|
⤷ |
pIC50
7.8
(IC50 1.5x10-8 M)
[27]
|
galanin-like peptide
{Sp: Human}
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.6 – 7.7
|
pIC50
|
7,27
|
|
⤷ |
pIC50
7.6 – 7.7
(IC50 2.8x10-8 – 1.87x10-8 M)
[7,27]
|
GALP(1-32) (human)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
7.2
|
pIC50
|
27
|
|
⤷ |
pIC50
7.2
(IC50 6.9x10-8 M)
[27]
|
galanin(5-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
6.7
|
pIC50
|
65
|
|
⤷ |
pIC50
6.7
(IC50 2x10-7 M)
[65]
|
galanin(3-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
<6.0
|
pIC50
|
17-18
|
|
⤷ |
pIC50
<6.0
(IC50 >1x10-6 M)
[17-18]
|
galanin(3-29) (rat/mouse)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.0
|
pIC50
|
22
|
|
⤷ |
pIC50
<6.0
(IC50 >1x10-6 M)
[22]
|
galanin(10-29) (pig)
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
6.0
|
pIC50
|
18
|
|
⤷ |
pIC50
6.0
(IC50 1x10-6 M)
[18]
|
alarin
{Sp: Rat}
|
|
|
|
|
|
|
|
|
|
|
Rn |
Agonist |
<6.0
|
pIC50
|
7
|
|
⤷ |
pIC50
<6.0
(IC50 >1x10-6 M)
[7]
|
[125I]spexin-1
|
|
|
|
|
|
|
|
|
|
|
Hs |
Agonist |
-
|
-
|
25
|
|
⤷ |
[25]
|