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Sphingolipid Δ4-desaturase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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DEGS1 and DEGS2 are 4TM proteins.

Enzymes

2484
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delta 4-desaturase, sphingolipid 1 C Show summary »

Target Id 2484
Nomenclature delta 4-desaturase, sphingolipid 1
Previous and unofficial names Cell migration-inducing gene 15 protein | degenerative spermatocyte homolog 1 (Drosophila) | Degs | delta(4)-desaturase | delta(4)-desaturase, sphingolipid 1 | DES1 | dihydroceramide desaturase-1 | FADS7 | Mdes | Membrane lipid desaturase | MLD
Genes DEGS1 (Hs), Degs1 (Mm), Degs1 (Rn)
Ensembl ID ENSG00000143753 (Hs), ENSMUSG00000038633 (Mm), ENSRNOG00000003223 (Rn)
UniProtKB AC O15121 (Hs), O09005 (Mm), Q5XIF5 (Rn)
EC number
1.14.-.-
Cofactors
NAD
Inhibitors
SKI II pKi 6.5 [3]
RBM2-1B pIC50 4.7 [2]
Comment Myristoylation of DEGS1 enhances its activity and targets it to the mitochondria [1].

delta 4-desaturase, sphingolipid 2 C Show summary »

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.