Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	5	394	9q31.3	UGCG	UDP-glucose ceramide glucosyltransferase
Mouse	5	394	4 B3	Ugcg	UDP-glucose ceramide glucosyltransferase
Rat	5	394	5q24	Ugcg	UDP-glucose ceramide glucosyltransferase

Previous and Unofficial Names

Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl

Database Links
Alphafold	Q16739 (Hs), O88693 (Mm), Q9R0E0 (Rn)
BRENDA	2.4.1.80
CATH/Gene3D	3.90.550.10
ChEMBL Target	CHEMBL2063 (Hs), CHEMBL6013 (Mm)
DrugBank Target	Q16739 (Hs)
Ensembl Gene	ENSG00000148154 (Hs), ENSMUSG00000028381 (Mm), ENSRNOG00000015644 (Rn)
Entrez Gene	7357 (Hs), 22234 (Mm), 83626 (Rn)
Human Protein Atlas	ENSG00000148154 (Hs)
KEGG Enzyme	2.4.1.80
KEGG Gene	hsa:7357 (Hs), mmu:22234 (Mm), rno:83626 (Rn)
OMIM	602874 (Hs)
Pharos	Q16739 (Hs)
RefSeq Nucleotide	NM_003358 (Hs), NM_011673 (Mm), NM_031795 (Rn)
RefSeq Protein	NP_003349 (Hs), NP_035803 (Mm), NP_113983 (Rn)
UniProtKB	Q16739 (Hs), O88693 (Mm), Q9R0E0 (Rn)
Wikipedia	UGCG (Hs)

Enzyme Reaction
EC Number: 2.4.1.80 UDP-glucose + ceramide = UDP + glucosylceramide

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference miglustat Hs Inhibition 5.1 pKi 2 ⤷ pKi 5.1 (Ki 7.4x10-6 M) [2] T-690 Hs Inhibition 7.8 pIC50 3 ⤷ pIC50 7.8 (IC50 1.5x10-8 M) [3] venglustat Hs Inhibition >5.3 pIC50 1 ⤷ pIC50 >5.3 (IC50 <5x10-6 M) [1] Description: Inhibition of glucosylceramide synthase activity in microsomes derived from human A375 melanoma cells, using fluorescent ceramide as substrate.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

General Comments
UDP-glucose ceramide glucosyltransferase (a.k.a. glucosylceramide synthase) is a key enzyme in glycolipid synthesis and it is a therapeutic target for the lysosomal storage disorder Gaucher's disease (GD). Inhibitors of this enzyme are predicted to reduce accumulation of glycosphingolipids (e.g. glucosylsphingosine) that are associated with disease pathologies.