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UDP-glucose ceramide glucosyltransferase

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Target not currently curated in GtoImmuPdb

Target id: 2528

Nomenclature: UDP-glucose ceramide glucosyltransferase

Family: Ceramide glucosyltransferase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 394 9q31.3 UGCG UDP-glucose ceramide glucosyltransferase
Mouse 5 394 4 B3 Ugcg UDP-glucose ceramide glucosyltransferase
Rat 5 394 5q24 Ugcg UDP-glucose ceramide glucosyltransferase
Previous and Unofficial Names Click here for help
Ugcgl | GLCT-1 | Glucosylceramide synthase | Epcs21 | GCS
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.4.1.80 UDP-glucose + ceramide = uridine diphosphate + glucosylceramide

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
miglustat Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition 5.1 pKi 1
pKi 5.1 (Ki 7.4x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033210 leptin-mediated signaling pathway ISS

References

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1. Butters TD, van den Broek LAGM, Fleet GWJ, Krulle TM, Wormald MR, Dwek RA, Platt FM. (2000) Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis. Tetrahedron: Assymetry, 11 (1): 113-124.

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