<i>GPRC5A</i> | Class C Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 258

Nomenclature: GPRC5A

Family: Class C Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 357 12p13.3 GPRC5A G protein-coupled receptor class C group 5 member A 2
Mouse 7 356 6 G1 Gprc5a G protein-coupled receptor, family C, group 5, member A
Rat 7 358 4q43 Gprc5a G protein-coupled receptor
Previous and Unofficial Names
RAIG1 | retinoic acid induced 3 | orphan G protein-coupling receptor PEIG-1 | retinoic acid-induced gene 1 protein | Retinoic acid-induced protein 3 | GPCR5A | RAI3 | G protein-coupled receptor, class C, group 5, member A | G protein-coupled receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
High expression in adult lung tissue.
Low to moderate expression in adult placenta, kidney, prostate, testis, ovary, small intestine and colon.
Not detectable in adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus and leukocyte.
Species:  Human
Technique:  Northern blotting.
References:  2
High expression in adult lung tissue.
Medium expression in adult kidnet and colon.
Low expression in adult heart, pancreas, placenta, ovary, prostate, small intestine and testis.
Not detectable in adult brain, liver, skeletal muscle, peripheral leukocyte, spleen and thymus.
Species:  Human
Technique:  RT-PCR
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
RAIG1 receptor knockout mice exhibit normal lung development, despite high expression of the gene in the wild-type lung.
Species:  Mouse
Technique:  Gene targeting in embryonic stem cells.
References:  3
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo
involves: 129 * C57BL/6
MGI:1891250  MP:0002048 increased lung adenoma incidence PMID: 18000218 
Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo
involves: 129 * C57BL/6
MGI:1891250  MP:0008014 increased lung tumor incidence PMID: 18000218 
Gprc5a+|Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5a+
involves: 129 * C57BL/6
MGI:1891250  MP:0008014 increased lung tumor incidence PMID: 18000218 
Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo
involves: 129 * C57BL/6
MGI:1891250  MP:0002027 lung adenocarcinoma PMID: 18000218 
Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo
involves: 129 * C57BL/6
MGI:1891250  MP:0001861 lung inflammation PMID: 18000218 
Gprc5atm1Jsx Gprc5atm1Jsx/Gprc5atm1Jsx
involves: 129X1/SvJ
MGI:1891250  MP:0002169 no abnormal phenotype detected PMID: 15677768 
General Comments
GPRC5A mRNA expression is induced by retinoic acid in some cell lines [4].


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1. Bräuner-Osborne H, Krogsgaard-Larsen P. (2000) Sequence and expression pattern of a novel human orphan G-protein-coupledreceptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics, 65: 121-128. [PMID:10783259]

2. Cheng Y, Lotan R. (1998) Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J Biol Chem., 273: 35008-35015. [PMID:9446598]

3. Xu J, Tian J, Shapiro SD. (2005) Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Am J Respir Cell Mol Biol, 32: 381-387. [PMID:15677768]

4. Ye X, Tao Q, Wang Y, Cheng Y, Lotan R. (2009) Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid. Cancer Biol. Ther., 8 (10): 951-62. [PMID:19279407]


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How to cite this page

Hans Bräuner-Osborne.
Class C Orphans: GPRC5A. Last modified on 18/04/2016. Accessed on 19/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=258.