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4-hydroxyphenylpyruvate dioxygenase

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Target not currently curated in GtoImmuPdb

Target id: 2621

Nomenclature: 4-hydroxyphenylpyruvate dioxygenase

Family: 1.-.-.- Oxidoreductases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 393 12q24.31 HPD 4-hydroxyphenylpyruvate dioxygenase
Mouse - 393 5 62.82 cM Hpd 4-hydroxyphenylpyruvic acid dioxygenase
Rat - 393 12q16 Hpd 4-hydroxyphenylpyruvate dioxygenase
Previous and Unofficial Names Click here for help
4HPPD | GLOD3
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
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RefSeq Nucleotide
RefSeq Protein
UniProtKB
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Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase
PDB Id:  3ISQ
Resolution:  1.75Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 1.13.11.27

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
nitisinone Small molecule or natural product Approved drug Primary target of this compound Pig Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 4x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Hawkinsinuria
OMIM: 140350
Orphanet: ORPHA2118
Disease:  Tyrosinemia, type III
Disease Ontology: DOID:0050727
OMIM: 276710
Orphanet: ORPHA69723

References

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1. Lin YL, Wu CS, Lin SW, Yang DY. (2000) SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett, 10 (9): 843-5. [PMID:10853644]

How to cite this page

1.-.-.- Oxidoreductases: 4-hydroxyphenylpyruvate dioxygenase. Last modified on 13/08/2015. Accessed on 03/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2621.