2.3.1.48 Histone acetyltransferases (HATs)

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Chromatin modifying enzymes
2.3.1.48 Histone acetyltransferases (HATs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

2694

clock circadian regulator Show summary »« Hide summary

elongator acetyltransferase complex subunit 3 Show summary »« Hide summary

general transcription factor IIIC subunit 4 Show summary »« Hide summary

Target Id

2656

Nomenclature

general transcription factor IIIC subunit 4

Previous and unofficial names

KAT12 | TFIIIC90 | general transcription factor IIIC, polypeptide 4, 90kDa | general transcription factor IIIC, polypeptide 4 | general transcription factor IIIC

Genes

GTF3C4 (Hs), Gtf3c4 (Mm), Gtf3c4 (Rn)

Ensembl ID

ENSG00000125484 (Hs), ENSMUSG00000035666 (Mm), ENSRNOG00000054725 (Rn)

UniProtKB AC

Q9UKN8 (Hs), Q8BMQ2 (Mm)

EC number

2.3.1.48

histone acetyltransferase 1 Show summary »« Hide summary

jumonji domain containing 1C Show summary »« Hide summary

lysine acetyltransferase 5 Show summary »« Hide summary

lysine acetyltransferase 6A Show summary »« Hide summary

lysine acetyltransferase 2A Show summary »« Hide summary More detailed page go icon to follow link

lysine acetyltransferase 2B Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2737
Nomenclature	lysine acetyltransferase 2B
Previous and unofficial names	GCN5 \| GCN5L \| PCAF \| Pcaf \| p300/CBP-associated factor \| K(lysine) acetyltransferase 2B
Genes	KAT2B (Hs), Kat2b (Mm), Kat2b (Rn)
Ensembl ID	ENSG00000114166 (Hs), ENSMUSG00000000708 (Mm), ENSRNOG00000011871 (Rn)
UniProtKB AC	Q92831 (Hs), Q9JHD1 (Mm)

lysine acetyltransferase 6B Show summary »« Hide summary

Target Id

2666

Nomenclature

lysine acetyltransferase 6B

Previous and unofficial names

MORF | MYST4 | K(lysine) acetyltransferase 6B

Genes

KAT6B (Hs), Kat6b (Mm)

Ensembl ID

ENSG00000156650 (Hs), ENSMUSG00000021767 (Mm)

UniProtKB AC

Q8WYB5 (Hs), Q8BRB7 (Mm)

EC number

2.3.1.48

lysine acetyltransferase 7 Show summary »« Hide summary

lysine acetyltransferase 8 Show summary »« Hide summary

Target Id

2668

Nomenclature

lysine acetyltransferase 8

Previous and unofficial names

HMOF | MYST1 | K(lysine) acetyltransferase 8 | K (lysine) acetyltransferase 8

Genes

KAT8 (Hs), Kat8 (Mm), Kat8 (Rn)

Ensembl ID

ENSG00000103510 (Hs), ENSMUSG00000030801 (Mm), ENSRNOG00000019485 (Rn)

UniProtKB AC

Q9H7Z6 (Hs), Q5XI06 (Rn)

EC number

2.3.1.48

Selective inhibitors

MG149 pIC₅₀ 4.3 [1]

nuclear receptor coactivator 1 Show summary »« Hide summary More detailed page go icon to follow link

nuclear receptor coactivator 2 Show summary »« Hide summary

Target Id	2694
Nomenclature	nuclear receptor coactivator 2
Previous and unofficial names	KAT13C \| P160
Genes	NCOA2 (Hs), Ncoa2 (Mm), Ncoa2 (Rn)
Ensembl ID	ENSG00000140396 (Hs), ENSMUSG00000005886 (Mm), ENSRNOG00000007975 (Rn)
UniProtKB AC	Q15596 (Hs), Q61026 (Mm), Q9WUI9 (Rn)

nuclear receptor coactivator 3 Show summary »« Hide summary

References

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How to cite this family page

Database page citation:

2.3.1.48 Histone acetyltransferases (HATs). Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=872.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.