Top ▲

ATPase family AAA domain containing 2B

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2720

Nomenclature: ATPase family AAA domain containing 2B

Family: 3.6.1.3 ATPases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1458 2p24.1-p23.3 ATAD2B ATPase family AAA domain containing 2B
Mouse - 1460 12 A1.1 Atad2b ATPase family, AAA domain containing 2B
Rat - 418 6q14 Atad2b ATPase family, AAA domain containing 2B
Previous and Unofficial Names Click here for help
ATPase family, AAA domain containing 2B | ATPase family
Database Links Click here for help
Alphafold Q9ULI0 (Hs), E9Q166 (Mm)
BRENDA 3.6.1.3
CATH/Gene3D 1.20.920.10
ChEMBL Target CHEMBL2176775 (Hs)
Ensembl Gene ENSG00000119778 (Hs), ENSMUSG00000052812 (Mm), ENSRNOG00000058973 (Rn)
Entrez Gene 54454 (Hs), 320817 (Mm), 500625 (Rn)
Human Protein Atlas ENSG00000119778 (Hs)
KEGG Enzyme 3.6.1.3
KEGG Gene hsa:54454 (Hs), mmu:320817 (Mm), rno:500625 (Rn)
OMIM 615347 (Hs)
Pharos Q9ULI0 (Hs)
RefSeq Nucleotide NM_001242338 (Hs), NM_001099628 (Mm), NM_001025151 (Rn)
RefSeq Protein NP_001229267 (Hs), NP_001093098 (Mm), NP_001020322 (Rn)
UniProtKB Q9ULI0 (Hs), E9Q166 (Mm)
Wikipedia ATAD2B (Hs)
Enzyme Reaction Click here for help
EC Number: 3.6.1.3

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK8814 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pIC50 2
⤷ pIC50 7.7 (IC50 1.99x10-8 M) [2]
Description: By TR-FRET assay.
compound 23 [PMID: 31398032] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.3 pIC50 1
⤷ pIC50 6.3 (IC50 5.01x10-7 M) [1]
Description: Measuring small-molecule competition using TR-FRET assay with ATAD2 construct 6 (Flag-6H-tev-ATAd2(981-1121) and the biotinylated triacetylated histone H4 peptide (SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGAKRHRKV-biotin).
General Comments
This is a bromo-domain containing protein involved in chromatin modification.

References

Show »

1. Bamborough P, Chung CW, Demont EH, Bridges AM, Craggs PD, Dixon DP, Francis P, Furze RC, Grandi P, Jones EJ et al.. (2019) A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J Med Chem, 62 (16): 7506-7525. [PMID:31398032]

2. Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T et al.. (2016) A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl, 55 (38): 11382-6. [PMID:27530368]

How to cite this page

3.6.1.3 ATPases: ATPase family AAA domain containing 2B. Last modified on 12/08/2019. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2720.