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Target not currently curated in GtoImmuPdb
Target id: 2726
Nomenclature: bromodomain containing 7
Abbreviated Name: BRD7
Family: Bromodomain kinase (BRDK) family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 651 | 16q12.1 | BRD7 | bromodomain containing 7 | |
Mouse | - | 651 | 8 C3 | Brd7 | bromodomain containing 7 | |
Rat | - | 406 | 19p11 | Brd7 | bromodomain containing 7 |
Previous and Unofficial Names ![]() |
BP75 | CELTIX1 |
Database Links ![]() |
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Alphafold | Q9NPI1 (Hs), O88665 (Mm) |
CATH/Gene3D | 1.20.920.10 |
ChEMBL Target | CHEMBL3085622 (Hs), CHEMBL3822348 (Mm) |
Ensembl Gene | ENSG00000166164 (Hs), ENSMUSG00000031660 (Mm), ENSRNOG00000014419 (Rn) |
Entrez Gene | 29117 (Hs), 26992 (Mm), 361374 (Rn) |
Human Protein Atlas | ENSG00000166164 (Hs) |
KEGG Gene | hsa:29117 (Hs), mmu:26992 (Mm), rno:361374 (Rn) |
Pharos | Q9NPI1 (Hs) |
RefSeq Nucleotide | NM_001173984 (Hs), NM_012047 (Mm), NM_001108440 (Rn) |
RefSeq Protein | NP_001167455 (Hs), NP_036177 (Mm), NP_001101910 (Rn) |
UniProtKB | Q9NPI1 (Hs), O88665 (Mm) |
Wikipedia | BRD7 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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General Comments |
BRD7 suppresses tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogene-induced senescence. This appears to be mediated by physical interaction between residues in the C-terminal domain of p53 and amino-terminal region of BRD7 [2]. |
1. Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, Monteiro OP, Bennett JM, Baronio R, Müller S et al.. (2015) LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl, 54 (21): 6217-21. [PMID:25864491]
2. Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R et al.. (2010) BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol, 12 (4): 380-9. [PMID:20228809]
3. SCC. BI-9564 A chemical probe for BRD9 and BRD7. Accessed on 11/12/2015. Modified on 11/12/2015. thesgc.org, http://www.thesgc.org/chemical-probes/BI-9564
4. SGC. TP-472 A BRD9/7 Probe. Accessed on 05/04/2017. Modified on 04/08/2023. Structural Genomics Consortium., https://www.thesgc.org/chemical-probes/TP-472
Bromodomain kinase (BRDK) family: bromodomain containing 7. Last modified on 05/04/2017. Accessed on 07/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2726.