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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

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Target not currently curated in GtoImmuPdb

Target id: 2739

Nomenclature: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Abbreviated Name: SMARCA2

Family: Non-enzymatic BRD containing proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1590 9p24.3 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Mouse - 1583 19 C1 Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Rat - 1597 1q51 Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Previous and Unofficial Names Click here for help
BAF190 | SNF2 | SNF2L2 | SNF2LA | SWI2 | SWI/SNF related
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GNE-064 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.6x10-8 M) [1]
Description: Potency determined by BromoScan assay
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Nicolaides-Baraitser syndrome
Synonyms: Intellectual disability - sparse hair - brachydactyly [Orphanet: ORPHA3051]
OMIM: 601358
Orphanet: ORPHA3051

References

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1. Taylor AM, Bailey C, Belmont LD, Campbell R, Cantone N, Côté A, Crawford TD, Cummings R, DeMent K, Duplessis M et al.. (2022) GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J Med Chem, 65 (16): 11177-11186. [PMID:35930799]

How to cite this page

Non-enzymatic BRD containing proteins: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. Last modified on 03/10/2022. Accessed on 29/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2739.