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Target not currently curated in GtoImmuPdb
Target id: 2739
Nomenclature: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
Abbreviated Name: SMARCA2
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1590 | 9p24.3 | SMARCA2 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | |
Mouse | - | 1583 | 19 C1 | Smarca2 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | |
Rat | - | 1597 | 1q51 | Smarca2 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 |
Previous and Unofficial Names ![]() |
BAF190 | SNF2 | SNF2L2 | SNF2LA | SWI2 | SWI/SNF related | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
Database Links ![]() |
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Alphafold | P51531 (Hs) |
CATH/Gene3D | 1.20.920.10, 2.130.10.10 |
ChEMBL Target | CHEMBL2362979 (Hs) |
Ensembl Gene | ENSG00000080503 (Hs), ENSMUSG00000024921 (Mm), ENSRNOG00000011931 (Rn) |
Entrez Gene | 6595 (Hs), 67155 (Mm), 361745 (Rn) |
Human Protein Atlas | ENSG00000080503 (Hs) |
KEGG Gene | hsa:6595 (Hs), mmu:67155 (Mm), rno:361745 (Rn) |
OMIM | 600014 (Hs) |
Pharos | P51531 (Hs) |
RefSeq Nucleotide | NM_003070 (Hs), NM_011416 (Mm), NM_001004446 (Rn) |
RefSeq Protein | NP_003061 (Hs), NP_035546 (Mm), NP_001004446 (Rn) |
UniProtKB | P51531 (Hs) |
Wikipedia | SMARCA2 (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | |||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C et al.. (2022) Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers. Nat Commun, 13 (1): 6814. [PMID:36357397]
2. Cochran AG, Flynn M. (2023) GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. J Med Chem, 66 (18): 13116-13134. [PMID:37702400]
3. Kotagiri S, Wang Y, Han Y, Liang X, Blazanin N, Mazhar H, Sebastian M, Nguyen PK, Jiang Y, Lissanu Y. (2025) Discovery of Novel, Potent, and Orally Bioavailable SMARCA2 Proteolysis-Targeting Chimeras with Synergistic Antitumor Activity in Combination with Kirsten Rat Sarcoma Viral Oncogene Homologue G12C Inhibitors. J Med Chem, 68 (9): 9202-9219. [PMID:40280558]
4. Lin H, Pitis P, Lu L, Combs AP. (2024) Brm targeting compounds and associated methods of use. Patent number: US20240018158A1. Assignee: Prelude Therapeutics Inc. Priority date: 15/05/2023. Publication date: 18/04/2024.
5. Taylor AM, Bailey C, Belmont LD, Campbell R, Cantone N, Côté A, Crawford TD, Cummings R, DeMent K, Duplessis M et al.. (2022) GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J Med Chem, 65 (16): 11177-11186. [PMID:35930799]
6. Yang L, Tu W, Huang L, Miao B, Kaneshige A, Jiang W, Leng L, Wang M, Wen B, Sun D et al.. (2023) Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem, 66 (15): 10761-10781. [PMID:37523716]
Non-enzymatic BRD containing proteins: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2. Last modified on 13/05/2025. Accessed on 13/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2739.