BCR activator of RhoGEF and GTPase | BCR family | IUPHAR/BPS Guide to PHARMACOLOGY

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BCR activator of RhoGEF and GTPase

Target not currently curated in GtoImmuPdb

Target id: 2755

Nomenclature: BCR activator of RhoGEF and GTPase

Family: BCR family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1271 22q11.23 BCR BCR activator of RhoGEF and GTPase
Mouse - 1270 10 B5.3-C1 Bcr BCR activator of RhoGEF and GTPase
Rat - - 20p12 Bcr BCR activator of RhoGEF and GTPase
Previous and Unofficial Names
BCR | BCR1 | Bcr1 | BCR, RhoGEF and GTPase activating protein | breakpoint cluster region | renal carcinoma antigen NY-REN-26
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
Clinically-Relevant Mutations and Pathophysiology
Disease:  Chronic myeloid leukemia
Disease Ontology: DOID:8552
OMIM: 608232
Orphanet: ORPHA521
Disease:  Precursor B-cell acute lymphoblastic leukemia
Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952]
Leukemia, acute lymphoblastic; ALL [OMIM: 613065]
Leukemia, B-cell acute lymphoblastic, susceptibility to [OMIM: 613065]
Disease Ontology: DOID:9952
OMIM: 613065
Orphanet: ORPHA99860
Disease:  Precursor T-cell acute lymphoblastic leukemia
Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952]
Leukemia, acute lymphoblastic; ALL [OMIM: 613065]
Leukemia, T-cell acute lymphoblastic, susceptibility to [OMIM: 613065]
Disease Ontology: DOID:9952
OMIM: 613065
Orphanet: ORPHA99861

How to cite this page

BCR family: BCR activator of RhoGEF and GTPase. Last modified on 27/03/2019. Accessed on 22/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2755.