Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1271	22q11.23	BCR	BCR activator of RhoGEF and GTPase
Mouse	-	1270	10 38.49 cM	Bcr	BCR activator of RhoGEF and GTPase
Rat	-	-	20p12	Bcr	BCR activator of RhoGEF and GTPase

Previous and Unofficial Names

BCR | BCR1 | Bcr1 | BCR, RhoGEF and GTPase activating protein | breakpoint cluster region | renal carcinoma antigen NY-REN-26

Database Links
Alphafold	P11274 (Hs), Q6PAJ1 (Mm)
BRENDA	2.7.11.1
CATH/Gene3D	2.30.29.30, 2.60.40.150
ChEMBL Target	CHEMBL5146 (Hs)
DrugBank Target	P11274 (Hs)
Ensembl Gene	ENSG00000186716 (Hs), ENSMUSG00000009681 (Mm), ENSRNOG00000001304 (Rn)
Entrez Gene	613 (Hs), 110279 (Mm), 309696 (Rn)
Human Protein Atlas	ENSG00000186716 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:613 (Hs), mmu:110279 (Mm), rno:309696 (Rn)
OMIM	151410 (Hs)
Pharos	P11274 (Hs)
RefSeq Nucleotide	NM_004327 (Hs), NM_001081412 (Mm)
RefSeq Protein	NP_004318 (Hs), NP_001074881 (Mm)
UniProtKB	P11274 (Hs), Q6PAJ1 (Mm)
Wikipedia	BCR (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 8 GO processes, IEA only click arrow to show/hide IEA associations GO:0002692 negative regulation of cellular extravasation IEA GO:0006909 phagocytosis IEA GO:0043312 neutrophil degranulation IEA GO:0043314 negative regulation of neutrophil degranulation IEA GO:0050728 negative regulation of inflammatory response IEA GO:0050766 positive regulation of phagocytosis IEA GO:1905517 macrophage migration IEA GO:1905522 negative regulation of macrophage migration IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes, IEA only click arrow to show/hide IEA associations GO:0002692 negative regulation of cellular extravasation IEA GO:0043314 negative regulation of neutrophil degranulation IEA GO:0050728 negative regulation of inflammatory response IEA GO:1905522 negative regulation of macrophage migration IEA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 3 GO processes, IEA only click arrow to show/hide IEA associations GO:0002692 negative regulation of cellular extravasation IEA GO:1905517 macrophage migration IEA GO:1905522 negative regulation of macrophage migration IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes, IEA only click arrow to show/hide IEA associations GO:0043312 neutrophil degranulation IEA GO:0043314 negative regulation of neutrophil degranulation IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Chronic myeloid leukemia Disease Ontology: DOID:8552 OMIM: 608232 Orphanet: ORPHA521
Disease:  Precursor B-cell acute lymphoblastic leukemia Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952] Leukemia, acute lymphoblastic; ALL [OMIM: 613065] Leukemia, B-cell acute lymphoblastic, susceptibility to [OMIM: 613065] Disease Ontology: DOID:9952 OMIM: 613065 Orphanet: ORPHA99860
Disease:  Precursor T-cell acute lymphoblastic leukemia Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952] Leukemia, acute lymphoblastic; ALL [OMIM: 613065] Leukemia, T-cell acute lymphoblastic, susceptibility to [OMIM: 613065] Disease Ontology: DOID:9952 OMIM: 613065 Orphanet: ORPHA99861