Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1403	5q13.2	NAIP	NLR family apoptosis inhibitory protein

Previous and Unofficial Names

baculoviral IAP repeat-containing 1 | BIRC1 | Birc1a | Birc1b | neuronal apoptosis inhibitory protein | NLRB1 | NLR family, apoptosis inhibitory protein | NLR family, apoptosis inhibitory protein 2 | NLR family, BIR domain containing 1 | psiNAIP

Database Links
Alphafold	Q13075 (Hs)
CATH/Gene3D	3.80.10.10
Ensembl Gene	ENSG00000249437 (Hs)
Entrez Gene	4671 (Hs)
Human Protein Atlas	ENSG00000249437 (Hs)
KEGG Gene	hsa:4671 (Hs)
OMIM	600355 (Hs)
Pharos	Q13075 (Hs)
RefSeq Nucleotide	NM_004536 (Hs)
RefSeq Protein	NP_004527 (Hs)
UniProtKB	Q13075 (Hs)
Wikipedia	NAIP (Hs)

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0002221 pattern recognition receptor signaling pathway NAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA GO:0032731 positive regulation of interleukin-1 beta production NAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0002221 pattern recognition receptor signaling pathway NAS GO:0050729 positive regulation of inflammatory response NAS

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0002221 pattern recognition receptor signaling pathway NAS GO:0050729 positive regulation of inflammatory response NAS click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Physiological Functions Comments

Involved in inflammasome formation, caspase-1 activation and inhibition of apoptosis.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Spinal muscular atrophy, type III; SMA3 Synonyms: Kugelberg-Welander disease Proximal spinal muscular atrophy type 3 [Orphanet: ORPHA83419] Spinal muscular atrophy [Disease Ontology: DOID:12377] Disease Ontology: DOID:12377 OMIM: 253400 Orphanet: ORPHA83419
Disease:  Spinal muscular atrophy, type II; SMA2 Synonyms: Proximal spinal muscular atrophy type 2 [Orphanet: ORPHA83418] Spinal muscular atrophy [Disease Ontology: DOID:12377] Disease Ontology: DOID:12377 OMIM: 253550 Orphanet: ORPHA83418
Disease:  Spinal muscular atrophy, type I; SMA1 Synonyms: Proximal spinal muscular atrophy type 1 [Orphanet: ORPHA83330] Spinal muscular atrophy [Disease Ontology: DOID:12377] Werdnig-Hoffmann disease Disease Ontology: DOID:12377 OMIM: 253300 Orphanet: ORPHA83330