Top ▲

egl-9 family hypoxia inducible factor 2

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2832

Nomenclature: egl-9 family hypoxia inducible factor 2

Abbreviated Name: PHD1

Family: Prolyl hydroxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 407 19q13.2 EGLN2 egl-9 family hypoxia inducible factor 2
Mouse - 419 7 15.83 cM Egln2 egl-9 family hypoxia-inducible factor 2
Rat - 415 1q21 Egln2 egl-9 family hypoxia-inducible factor 2
Gene and Protein Information Comments
Using alternative methionine initiation codons, two isoforms of human EGLN2 have been reported , generating PHD1p40 (374 amino acids; UniProt identifier Q96KS0-2) and PHD1p43 (407 amino acids; UniProt identifier Q96KS0-1). PHD1p43 is considered the canonocal protein.
Previous and Unofficial Names Click here for help
HIF prolyl hydroxylase 1 | HIFPH1 | egl-9 family hypoxia-inducible factor 2
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.11.29

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6ee [PMID: 22364528] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.7 pIC50 1
pIC50 9.7 (IC50 2x10-10 M) [1]

References

Show »

1. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem, 55 (7): 2945-59. [PMID:22364528]

How to cite this page

Prolyl hydroxylases: egl-9 family hypoxia inducible factor 2. Last modified on 17/07/2017. Accessed on 29/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2832.