Top ▲

reticulon 4

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2838

Nomenclature: reticulon 4

Family: Reticulons and associated proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 1192 2p16.1 RTN4 reticulon 4 2
Mouse 2 1162 11 A3.3 Rtn4 reticulon 4
Rat 2 1163 14q22 Rtn4 reticulon 4
Gene and Protein Information Comments
Human reticulon 4 has three reported alternatively spliced isoforms, RTN4A, -4B, and -4C (aka NOGO-A, -B and -C). The longest, and canonical sequence is RTN4A with 1192 amino acids. RTN4B lacks an in-frame segment of the coding region compared to RTN4A and is only 373 amino acids long. RTN4C differs from RTN4A in its 5' UTR and 5' coding region, resulting in a shorter protein (199 amino acids) with a distinct N-terminus. Similarly, the mouse gene is also alternatively spliced resulting in several protein isoforms. The longest is Rtn4A which is shown in the table above. Thus far only one rat Rtn4 isoform is reported.
Previous and Unofficial Names Click here for help
NOGO | NSP-CL | RTN4-XL | ASY
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
ozanezumab Peptide Primary target of this compound Hs Binding 9.2 pKd 1
pKd 9.2 (Kd 6.4x10-10 M) [1]
Description: Binding dissociation constant for clone H28L16.
Antibody Comments
The binding dissociation constant for ozanezumab is for binding to the RTN4A (NOGO-A) isoform.
Immuno Process Associations
Immuno Process:  Cellular signalling
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0002523 leukocyte migration involved in inflammatory response ISS
GO:1902624 positive regulation of neutrophil migration ISS
GO:1905523 positive regulation of macrophage migration ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0060907 positive regulation of macrophage cytokine production ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0060907 positive regulation of macrophage cytokine production ISS
GO:1902624 positive regulation of neutrophil migration ISS
GO:1905523 positive regulation of macrophage migration ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002523 leukocyte migration involved in inflammatory response ISS
GO:1902624 positive regulation of neutrophil migration ISS
GO:1905523 positive regulation of macrophage migration ISS

References

Show »

1. Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. (2007) Immunoglobulins. Patent number: US8362208. Assignee: Glaxo Group Ltd , Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. Priority date: 16/12/2005. Publication date: 29/11/2007.

2. Yang J, Yu L, Bi AD, Zhao SY. (2000) Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. Cytogenet Cell Genet, 88 (1-2): 101-2. [PMID:10773680]

How to cite this page

Reticulons and associated proteins: reticulon 4. Last modified on 11/12/2018. Accessed on 05/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2838.