Top ▲
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 2 | 1192 | 2p16.1 | RTN4 | reticulon 4 | 2 |
Mouse | 2 | 1162 | 11 A3.3 | Rtn4 | reticulon 4 | |
Rat | 2 | 1163 | 14q22 | Rtn4 | reticulon 4 | |
Gene and Protein Information Comments | ||||||
Human reticulon 4 has three reported alternatively spliced isoforms, RTN4A, -4B, and -4C (aka NOGO-A, -B and -C). The longest, and canonical sequence is RTN4A with 1192 amino acids. RTN4B lacks an in-frame segment of the coding region compared to RTN4A and is only 373 amino acids long. RTN4C differs from RTN4A in its 5' UTR and 5' coding region, resulting in a shorter protein (199 amino acids) with a distinct N-terminus. Similarly, the mouse gene is also alternatively spliced resulting in several protein isoforms. The longest is Rtn4A which is shown in the table above. Thus far only one rat Rtn4 isoform is reported. |
Previous and Unofficial Names |
NOGO | NSP-CL | RTN4-XL | ASY |
Database Links | |
Alphafold | Q9NQC3 (Hs), Q99P72 (Mm), Q9JK11 (Rn) |
ChEMBL Target | CHEMBL3712895 (Hs) |
Ensembl Gene | ENSG00000115310 (Hs), ENSMUSG00000020458 (Mm), ENSRNOG00000004621 (Rn) |
Entrez Gene | 57142 (Hs), 68585 (Mm), 83765 (Rn) |
Human Protein Atlas | ENSG00000115310 (Hs) |
KEGG Gene | hsa:57142 (Hs), mmu:68585 (Mm), rno:83765 (Rn) |
OMIM | 604475 (Hs) |
Pharos | Q9NQC3 (Hs) |
RefSeq Nucleotide | NM_007008 (Hs), NM_020532 (Hs), NM_153828 (Hs), NM_194052 (Mm), NM_194054 (Mm), NM_024226 (Mm), NM_031831 (Rn) |
RefSeq Protein | NP_065393 (Hs), NP_722550 (Hs), NP_008939 (Hs), NP_077188 (Mm), NP_918941 (Mm), NP_918943 (Mm), NP_114019 (Rn) |
UniProtKB | Q9NQC3 (Hs), Q99P72 (Mm), Q9JK11 (Rn) |
Wikipedia | RTN4 (Hs) |
Download all structure-activity data for this target as a CSV file
Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||
Antibody Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
The binding dissociation constant for ozanezumab is for binding to the RTN4A (NOGO-A) isoform. |
Immuno Process Associations | ||
|
||
|
||
|
||
|
||
|
1. Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. (2007) Immunoglobulins. Patent number: US8362208. Assignee: Glaxo Group Ltd , Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. Priority date: 16/12/2005. Publication date: 29/11/2007.
2. Yang J, Yu L, Bi AD, Zhao SY. (2000) Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. Cytogenet Cell Genet, 88 (1-2): 101-2. [PMID:10773680]
Reticulons and associated proteins: reticulon 4. Last modified on 11/12/2018. Accessed on 28/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2838.