Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	289	14q11.2	PNP	purine nucleoside phosphorylase
Mouse	-	289	14 26.31 cM	Pnp	purine-nucleoside phosphorylase
Rat	-	289	15p14	Pnp	purine nucleoside phosphorylase
Gene and Protein Information Comments
The Antimalarial targets family provides information about P. falciparum PNP.

Previous and Unofficial Names

NP | nucleoside phosphorylase | PUNP

Database Links
Alphafold	P00491 (Hs), P23492 (Mm), P85973 (Rn)
BRENDA	1.4.2.1
ChEMBL Target	CHEMBL4338 (Hs), CHEMBL2215 (Mm), CHEMBL2395 (Rn)
DrugBank Target	P00491 (Hs)
Ensembl Gene	ENSG00000198805 (Hs), ENSMUSG00000115338 (Mm), ENSRNOG00000009982 (Rn)
Entrez Gene	4860 (Hs), 18950 (Mm), 290029 (Rn)
Human Protein Atlas	ENSG00000198805 (Hs)
KEGG Enzyme	1.4.2.1
KEGG Gene	hsa:4860 (Hs), mmu:18950 (Mm), rno:290029 (Rn)
OMIM	164050 (Hs)
Pharos	P00491 (Hs)
RefSeq Nucleotide	NM_000270 (Hs), NP_038660 (Mm), NM_013632 (Mm), NM_001106031 (Rn)
RefSeq Protein	NP_000261 (Hs), NP_001099501 (Rn)
SynPHARM	81910 (in complex with forodesine)
UniProtKB	P00491 (Hs), P23492 (Mm), P85973 (Rn)
Wikipedia	PNP (Hs)

Selected 3D Structures
	Description:  Crystal structure of human PNP complexed with immucillin H. PDB Id:  1PF7 Ligand:  forodesine Resolution:  2.6Å Species:  Human References:  1

Enzyme Reaction
EC Number: 1.4.2.1 Description Reaction Reference Purine-nucleoside phosphorylase Purine nucleoside + phosphate <=> purine + alpha-D-ribose 1-phosphate Purine deoxynucleoside + phosphate <=> purine + 2'-deoxy-alpha-D-ribose 1-phosphate

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference forodesine Hs Inhibition 10.1 pKi 2 ⤷ pKi 10.1 (Ki 7.2x10-11 M) [2]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling

Immuno Process:  B cell (activation)

Clinically-Relevant Mutations and Pathophysiology
Disease:  Purine nucleoside phosphorylase deficiency Disease Ontology: DOID:5813 OMIM: 613179 Orphanet: ORPHA760

General Comments
PNP is required for the recycling of nucleosides and deoxynucleosides. In humans, PNP is the only route for degradation of deoxyguanosine. T cells are sensitive to deficiencies of this enzyme, and genetic deficiency of PNP causes loss of T cell function from birth and leads to significant immunodeficiency [3].