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acyloxyacyl hydrolase

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Target not currently curated in GtoImmuPdb

Target id: 2873

Nomenclature: acyloxyacyl hydrolase

Family: 3.1.1.- Carboxylic Ester Hydrolases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 575 7p14.2 AOAH acyloxyacyl hydrolase
Mouse - 574 13 A2 Aoah acyloxyacyl hydrolase
Rat - 574 17q11 Aoah acyloxyacyl hydrolase
Previous and Unofficial Names Click here for help
acyloxyacyl hydrolase (neutrophil)
Database Links Click here for help
Alphafold P28039 (Hs), O35298 (Mm)
BRENDA 3.1.1.77
Ensembl Gene ENSG00000136250 (Hs), ENSMUSG00000021322 (Mm), ENSRNOG00000054964 (Rn)
Entrez Gene 313 (Hs), 27052 (Mm), 498757 (Rn)
Human Protein Atlas ENSG00000136250 (Hs)
KEGG Enzyme 3.1.1.77
KEGG Gene hsa:313 (Hs), mmu:27052 (Mm), rno:498757 (Rn)
OMIM 102593 (Hs)
Pharos P28039 (Hs)
RefSeq Nucleotide NM_001177506 (Hs), NM_012054 (Mm), NM_001191940 (Rn)
RefSeq Protein NP_001170977 (Hs), NP_036184 (Mm), NP_001178869 (Rn)
UniProtKB P28039 (Hs), O35298 (Mm)
Wikipedia AOAH (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.1.77

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
JZL195 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pIC50 1
⤷ pIC50 7.4 (IC50 4.4x10-8 M) [1]

References

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1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol, 10 (8): 656-63. [PMID:24997602]

How to cite this page

3.1.1.- Carboxylic Ester Hydrolases: acyloxyacyl hydrolase. Last modified on 29/01/2016. Accessed on 07/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2873.