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heat shock protein 90 alpha family class A member 1

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Target not currently curated in GtoImmuPdb

Target id: 2905

Nomenclature: heat shock protein 90 alpha family class A member 1

Abbreviated Name: HSP90AA1

Family: Heat shock proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 14q32.31 HSP90AA1 heat shock protein 90 alpha family class A member 1
Mouse - 733 12 60.75 cM Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1
Rat - 14 6q32 Hsp90aa1 heat shock protein 90 alpha family class A member 1
Previous and Unofficial Names Click here for help
HSP90AA1
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
retaspimycin hydrochloride Small molecule or natural product Hs Inhibition 6.9 pEC50 2
pEC50 6.9 (EC50 1.19x10-7 M) [2]
BIIB021 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 2x10-9 M) [1]
SNX0723 Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3x10-9 M) [1]
alvespimycin Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 8.4 pIC50 3
pIC50 8.4 (IC50 4.5x10-9 M) [3]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0006898 receptor-mediated endocytosis TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0045585 positive regulation of cytotoxic T cell differentiation TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0031396 regulation of protein ubiquitination IDA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043312 neutrophil degranulation TAS
GO:0045585 positive regulation of cytotoxic T cell differentiation TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0045585 positive regulation of cytotoxic T cell differentiation TAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045585 positive regulation of cytotoxic T cell differentiation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045585 positive regulation of cytotoxic T cell differentiation TAS

References

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1. Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. (2014) Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases. Bioorg. Med. Chem. Lett., 24 (1): 204-8. [PMID:24332488]

2. Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J et al.. (2006) Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J. Med. Chem., 49 (15): 4606-15. [PMID:16854066]

3. Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ et al.. (2008) Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg. Med. Chem. Lett., 18 (23): 6273-8. [PMID:18929486]

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class A member 1. Last modified on 04/03/2018. Accessed on 01/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2905.