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Target not currently curated in GtoImmuPdb
Target id: 2905
Nomenclature: heat shock protein 90 alpha family class A member 1
Abbreviated Name: HSP90AA1
Family: Heat shock proteins
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 732 | 14q32.31 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | |
Mouse | - | 733 | 12 60.75 cM | Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | |
Rat | - | 14 | 6q32 | Hsp90aa1 | heat shock protein 90 alpha family class A member 1 |
Previous and Unofficial Names |
HSP90AA1 |
Database Links | |
Alphafold | P07900 (Hs), P07901 (Mm), P82996 (Rn) |
CATH/Gene3D | 3.30.565.10 |
ChEMBL Target | CHEMBL3880 (Hs), CHEMBL4197 (Mm) |
Ensembl Gene | ENSG00000080824 (Hs), ENSMUSG00000021270 (Mm), ENSRNOG00000059714 (Rn) |
Entrez Gene | 3320 (Hs), 15519 (Mm), 299331 (Rn) |
Human Protein Atlas | ENSG00000080824 (Hs) |
KEGG Gene | hsa:3320 (Hs), mmu:15519 (Mm), rno:299331 (Rn) |
Pharos | P07900 (Hs) |
RefSeq Nucleotide | NM_005348 (Hs), NM_010480 (Mm), NM_175761 (Rn) |
RefSeq Protein | NP_005339 (Hs), NP_034610 (Mm), NP_786937 (Rn) |
SynPHARM |
84900 (in complex with alvespimycin) 83738 (in complex with BIIB021) 83739 (in complex with SNX0723) |
UniProtKB | P07900 (Hs), P07901 (Mm), P82996 (Rn) |
Wikipedia | HSP90AA1 (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. (2014) Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases. Bioorg Med Chem Lett, 24 (1): 204-8. [PMID:24332488]
2. Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J et al.. (2006) Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem, 49 (15): 4606-15. [PMID:16854066]
3. Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ et al.. (2008) Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg Med Chem Lett, 18 (23): 6273-8. [PMID:18929486]
4. Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq K, Bosma R, Nederpelt I, Heitman LH et al.. K4DD drug target binding kinetics data. ,. DOI: 10.6019/CHEMBL3885741
5. Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D et al.. (2013) Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem, 56 (17): 6803-18. [PMID:23965125]
Heat shock proteins: heat shock protein 90 alpha family class A member 1. Last modified on 03/04/2024. Accessed on 08/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2905.