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target has curated data in GtoImmuPdb
Target id: 2927
Nomenclature: C-type lectin domain family 7 member A
Abbreviated Name: Dectin-1
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 247 | 12p13.2 | CLEC7A | C-type lectin domain containing 7A | |
| Mouse | 1 | 244 | 6 F3 | Clec7a | C-type lectin domain family 7, member a | |
| Rat | 1 | 235 | Clec7a | C-type lectin domain containing 7A | ||
| Gene and Protein Information Comments | ||||||
| There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified. | ||||||
| Previous and Unofficial Names |
| C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7 |
| Database Links |
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| Alphafold | Q9BXN2 (Hs), Q6QLQ4 (Mm) |
| CATH/Gene3D | 3.10.100.10 |
| ChEMBL Target | CHEMBL2034810 (Hs), CHEMBL2034809 (Mm) |
| Ensembl Gene | ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn) |
| Entrez Gene | 64581 (Hs), 56644 (Mm), 502902 (Rn) |
| Human Protein Atlas | ENSG00000172243 (Hs) |
| KEGG Gene | hsa:64581 (Hs), mmu:56644 (Mm), rno:502902 (Rn) |
| OMIM | 606264 (Hs) |
| Pharos | Q9BXN2 (Hs) |
| RefSeq Nucleotide | NM_197947 (Hs), NM_020008 (Mm), NM_001173386 (Rn) |
| RefSeq Protein | NP_922938 (Hs), NP_064392 (Mm), NP_001166857 (Rn) |
| UniProtKB | Q9BXN2 (Hs), Q6QLQ4 (Mm) |
| Wikipedia | CLEC7A (Hs) |
| Agonist Comments | ||
| A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2]. |
| Immunopharmacology Comments |
| Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1]. |
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| General Comments |
| Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). |
1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]
2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]
C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.
