C-type lectin domain family 7 member A | C-type lectin-like receptors (CLRs) | IUPHAR/BPS Guide to PHARMACOLOGY

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C-type lectin domain family 7 member A

target has curated data in GtoImmuPdb

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 C6, 63.34 cM, cytoband F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0002366 leukocyte activation involved in immune response IDA
GO:0006910 phagocytosis, recognition IDA
GO:0008329 signaling pattern recognition receptor activity IDA
GO:0050766 positive regulation of phagocytosis IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0006910 phagocytosis, recognition IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0042110 T cell activation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002732 positive regulation of dendritic cell cytokine production IDA
GO:0008329 signaling pattern recognition receptor activity IDA
GO:0051251 positive regulation of lymphocyte activation IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0002366 leukocyte activation involved in immune response IDA
GO:0008329 signaling pattern recognition receptor activity IDA
GO:0042110 T cell activation TAS
GO:0051251 positive regulation of lymphocyte activation IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 12 GO processes
GO:0002367 cytokine production involved in immune response IDA
GO:0002732 positive regulation of dendritic cell cytokine production IDA
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
GO:0045082 positive regulation of interleukin-10 biosynthetic process IDA
GO:0045084 positive regulation of interleukin-12 biosynthetic process IDA
GO:0045086 positive regulation of interleukin-2 biosynthetic process IDA
GO:0045410 positive regulation of interleukin-6 biosynthetic process IDA
GO:0045416 positive regulation of interleukin-8 biosynthetic process IMP
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Brown GD, Gordon S. (2001) Immune recognition: A new receptor for β-glucans. Nature, 413: 36-37 Brief Communications.

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg. Med. Chem., 20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 15/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.