SLC57 NiPA-like magnesium transporter family | Transporters

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SLC57 NiPA-like magnesium transporter family

SLC57 NiPA-like magnesium transporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

3033

NIPA magnesium transporter 1 / SLC57A1 C Show summary »« Hide summary

Target Id

3033

Nomenclature

NIPA magnesium transporter 1

Systematic nomenclature

SLC57A1

Previous and unofficial names

NIPA3 [2] | non imprinted in Prader-Willi/Angelman syndrome 1 | SPG6

Genes

NIPA1 (Hs), Nipa1 (Mm), Nipa1 (Rn)

Ensembl ID

ENSG00000170113 (Hs), ENSMUSG00000047037 (Mm), ENSRNOG00000042702 (Rn)

UniProtKB AC

Q7RTP0 (Hs), Q8BHK1 (Mm)

RESOLUTE

NIPA1 (Hs)

Substrates

Mg²⁺ [1]

Sr²⁺, Fe²⁺ and Co²⁺ to a lesser extent [2]

Comment

Human tissue expression: Constitutively expressed at low levels, with significant enrichment in the brain [3].
Mouse tissue expression: Widely expressed, including in the heart, kidney, liver, colon, less in the brain, and not in the small intestine [1].

NIPA magnesium transporter 2 / SLC57A2 C Show summary »« Hide summary

Target Id

3034

Nomenclature

NIPA magnesium transporter 2

Systematic nomenclature

SLC57A2

Previous and unofficial names

non imprinted in Prader-Willi/Angelman syndrome 2

Genes

NIPA2 (Hs), Nipa2 (Mm), Nipa2 (Rn)

Ensembl ID

ENSG00000140157 (Hs), ENSMUSG00000030452 (Mm), ENSRNOG00000012690 (Rn)

UniProtKB AC

Q8N8Q9 (Hs), Q9JJC8 (Mm)

RESOLUTE

NIPA2 (Hs)

Substrates

Mg²⁺ [2]

NIPA like domain containing 1 / SLC57A3 C Show summary »« Hide summary

NIPA like domain containing 2 / SLC57A4 Show summary »« Hide summary

NIPA like domain containing 3 / SLC57A5 C Show summary »« Hide summary

NIPA like domain containing 4 / SLC57A6 Show summary »« Hide summary

References

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1. Goytain A, Hines RM, El-Husseini A, Quamme GA. (2007) NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter. J Biol Chem, 282 (11): 8060-8. [PMID:17166836]

2. Goytain A, Hines RM, Quamme GA. (2008) Functional characterization of NIPA2, a selective Mg2+ transporter. Am J Physiol, Cell Physiol, 295 (4): C944-53. [PMID:18667602]

3. Rainier S, Chai JH, Tokarz D, Nicholls RD, Fink JK. (2003) NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am J Hum Genet, 73 (4): 967-71. [PMID:14508710]

How to cite this family page

Database page citation:

SLC57 NiPA-like magnesium transporter family. Accessed on 03/05/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1009.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC57 NiPA-like magnesium transporter family C

Transporters

Further reading

References

How to cite this family page