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Target not currently curated in GtoImmuPdb
Target has curated data in GtoMPdb
Target id: 3090
Nomenclature: Plasmodium falciparum type II NADH:ubiquinone oxidoreductase
Abbreviated Name: PfNDH2
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Plasmodium falciparum 3D7 | - | 533 | NDH2 | type II NADH:ubiquinone oxidoreductase | ||
| Previous and Unofficial Names |
| NDH2 | Pf3D7_09_v3:639,648..641,731(-) | PFI0735c |
| Database Links |
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| Alphafold | Q8I302 (Pf3D7) |
| PlasmoDB | PF3D7_0915000 (Pf3D7) |
| UniProtKB | Q8I302 (Pf3D7) |
| Selected 3D Structures |
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| Malaria Pharmacology Comments |
| Type II NADH:ubiquinone oxidoreductase (NDH2) is an enzyme in the mitochondrial electron transport chain that is not present in mammals but is found in many species including those of the malaria parasite. It has been considered to be a promising antimalarial drug target for a number of years, but a recent study questions this with the demonstration that PfNDH2 is not essential in the asexual blood stages of P. falciparum development [2]. In the P. berghei mouse model, NDH2 has been shown to be essential for sporogony inside the mosquito vector and may be required for malaria transmission [1]. |
1. Boysen KE, Matuschewski K. (2011) Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J Biol Chem, 286 (37): 32661-71. [PMID:21771793]
2. Ke H, Ganesan SM, Dass S, Morrisey JM, Pou S, Nilsen A, Riscoe MK, Mather MW, Vaidya AB. (2019) Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages. PLoS ONE, 14 (4): e0214023. [PMID:30964863]
3. Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L, Rao Y et al.. (2017) Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria. J Med Chem, 60 (5): 1994-2005. [PMID:28195463]
Mitochondrial function/Mitochondrial electron flow: Plasmodium falciparum type II NADH:ubiquinone oxidoreductase. Last modified on 11/10/2021. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3090.
