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Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase beta

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3091

Nomenclature: Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase beta

Abbreviated Name: PfPDEbeta

Family: Cyclic nucleotide turnover/signalling (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1139 PDEbeta 3',5'-cyclic nucleotide phosphodiesterase beta
Previous and Unofficial Names Click here for help
MAL13P1.118 | PDEβ
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Malaria Pharmacology Comments
P. falciparum 3',5'-cyclic nucleotide phosphodiesterase beta (PfPDEbeta) hydrolyses both cyclic AMP and cyclic GMP and is essential during the asexual blood stage of the parasite lifecycle [1].
PfPDEbeta is a target "under consideration" in the Malaria Drug Accelerator (MalDA) portfolio [2].

References

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1. Flueck C, Drought LG, Jones A, Patel A, Perrin AJ, Walker EM, Nofal SD, Snijders AP, Blackman MJ, Baker DA. (2019) Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. PLoS Biol, 17 (2): e3000154. [PMID:30794532]

2. Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK et al.. (2021) Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS Infect Dis, 7 (10): 2764-2776. [PMID:34523908]

How to cite this page

Cyclic nucleotide turnover/signalling (Plasmodium spp.): Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase beta. Last modified on 13/12/2021. Accessed on 07/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3091.