Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	201	6p21.33	NCR3	natural cytotoxicity triggering receptor 3
Mouse	-	-	17 B1	Ncr3-ps	natural cytotoxicity triggering receptor 3, pseudogene
Rat	1	192	20p12	Ncr3	natural cytotoxicity triggering receptor 3

Previous and Unofficial Names

natural cytotoxicity triggering receptor 3, pseudogene | natural cytotoxicity triggering receptor 3

Database Links
Alphafold	O14931 (Hs), Q8CFD9 (Rn)
Ensembl Gene	ENSG00000204475 (Hs), ENSMUSG00000086076 (Mm), ENSRNOG00000000854 (Rn)
Entrez Gene	259197 (Hs), 667612 (Mm), 294251 (Rn)
Human Protein Atlas	ENSG00000204475 (Hs)
KEGG Gene	hsa:259197 (Hs), mmu:667612 (Mm), rno:294251 (Rn)
Pharos	O14931 (Hs)
UniProtKB	O14931 (Hs), Q8CFD9 (Rn)
Wikipedia	NCR3 (Hs)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference Natural cytotoxicity triggering receptor 3 ligand 1 {Sp: Human} Hs Activation - - ⤷ Large proline-rich protein BAG6 Hs Activation - - ⤷

Immunopharmacology Comments

Activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands.