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ACKR4

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 315

Nomenclature: ACKR4

Family: Chemokine receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 350 3q22.1 ACKR4 atypical chemokine receptor 4
Mouse 7 350 9 F1 Ackr4 atypical chemokine receptor 4
Rat - - 8q32 Ackr4 atypical chemokine receptor 4
Previous and Unofficial Names Click here for help
CC-CKR-11 | CCR10 | CKR-11 | CCR11 | PPR1 | VSHK1
Database Links Click here for help
Specialist databases
GPCRdb ackr4_human (Hs), ackr4_mouse (Mm)
Other databases
Alphafold Q9NPB9 (Hs), Q924I3 (Mm)
Ensembl Gene ENSG00000129048 (Hs), ENSMUSG00000079355 (Mm), ENSRNOG00000011478 (Rn)
Entrez Gene 51554 (Hs), 252837 (Mm)
Human Protein Atlas ENSG00000129048 (Hs)
KEGG Gene hsa:51554 (Hs), mmu:252837 (Mm)
OMIM 606065 (Hs)
Pharos Q9NPB9 (Hs)
RefSeq Nucleotide NM_178445 (Hs), NM_145700 (Mm)
RefSeq Protein NP_848540 (Hs), NP_663746 (Mm)
UniProtKB Q9NPB9 (Hs), Q924I3 (Mm)
Wikipedia ACKR4 (Hs)
Natural/Endogenous Ligands Click here for help
CCL19 {Sp: Human}
CCL21 {Sp: Human}
CCL25 {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CCL19 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 8.4 pKi 1
⤷ pKi 8.4 [1]
CCL25 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 7.6 pKi 1
⤷ pKi 7.6 [1]
CCL21 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 6.9 pKi 1
⤷ pKi 6.9 [1]
CCL19 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 8.5 – 9.1 pEC50 1
⤷ pEC50 8.5 – 9.1 [1]
CCL21 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 7.9 – 8.5 pEC50 1
⤷ pEC50 7.9 – 8.5 [1]
CCL25 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 7.9 – 8.3 pEC50 1
⤷ pEC50 7.9 – 8.3 [1]
Agonist Comments
Although CCRL1 binds chemokines CCL19, CCL21 and CCL25 with high affinity, these chemokines are interanlised by the receptor and there is no known activation of intracellular signalling pathways. CCRL1 therefore acts as a decoy receptor for these chemokines and prevents their interactions with other chemokine receptors [1].
Immunopharmacology Comments
ACKR4 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Antigen presentation
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccrl1tm1Dgen Ccrl1tm1Dgen/Ccrl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:2181676  MP:0002169 no abnormal phenotype detected

References

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1. Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ et al.. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J Biol Chem, 288 (10): 7169-81. [PMID:23341447]

Contributors

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