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Plasmodium falciparum tryptophanyl-tRNA synthetase

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3166

Nomenclature: Plasmodium falciparum tryptophanyl-tRNA synthetase

Abbreviated Name: PfaWRS

Family: Aminoacyl-tRNA synthetases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 559 aTrpRS tryptophan--tRNA ligase
Gene and Protein Information Comments
The Plasmodium genome encodes two forms of tryptophanyl-tRNA synthetase, one found in the cytoplasm (PfcWRS, encoded by PF3D7_1336900) and one in the apicoplast (PfaWRS, described here).
Previous and Unofficial Names Click here for help
PfaTrpRS | TrpRSapi | PFL2485c | Plasmodium falciparum tryptophan--tRNA ligase
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
indolmycin Small molecule or natural product Ligand has a PDB structure Guide to Malaria Pharmacology Ligand Pf3D7 - - 5.8 pIC50 1
pIC50 5.8 (IC50 1.7x10-6 M) SYBR Green susceptibility assay determined 96 hrs after drug treatment [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

References

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1. Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA. (2016) Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum. Sci Rep, 6: 27531. [PMID:27277538]

How to cite this page

Aminoacyl-tRNA synthetases: Plasmodium falciparum tryptophanyl-tRNA synthetase. Last modified on 29/03/2022. Accessed on 07/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3166.