Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	688		SUB1	subtilisin-like protease 1

Previous and Unofficial Names

SUB1 | Pf3D7_05_v3:307,090..310,120(-) | PFE0370c

Database Links
Alphafold	Q8I0V0 (Pf3D7)
PlasmoDB	PF3D7_0507500 (Pf3D7)
UniProtKB	Q8I0V0 (Pf3D7)

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 3j [PMID: 33975947] Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ - 8.2 pIC50 1 ⤷ pIC50 8.2 (IC50 5.7x10-9 M) [1]

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference compound 3j [PMID: 33975947] Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ Parasite growth inhibition assay - - 6.6 pEC50 1 ⤷ pEC50 6.6 (EC50 2.6x10-7 M) SYBR Green I assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

P. falciparum subtilisin-like protease 1 (PfSUB1) is a serine protease involved in the process of merozoite release from host erythrocytes (egress) and is essential for survival of the parasite.