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Plasmodium falciparum subtilisin-like protease 1

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3184

Nomenclature: Plasmodium falciparum subtilisin-like protease 1

Abbreviated Name: PfSUB1

Family: Peptidases and proteinases (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 688 SUB1 subtilisin-like protease 1
Previous and Unofficial Names Click here for help
SUB1 | subtilisin-like protease 1
Database Links Click here for help
PlasmoDB
UniProtKB
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3j [PMID: 33975947] Small molecule or natural product Pf3D7 - 8.2 pIC50 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
compound 3j [PMID: 33975947] Small molecule or natural product Pf3D7 Parasite growth inhibition assay - - 6.6 pEC50 1
pEC50 6.6 (EC50 2.6x10-7 M) SYBR Green I assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
P. falciparum subtilisin-like protease 1 (PfSUB1) is a serine protease involved in the process of merozoite release from host erythrocytes (egress) and is essential for survival of the parasite.

References

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1. Lidumniece E, Withers-Martinez C, Hackett F, Collins CR, Perrin AJ, Koussis K, Bisson C, Blackman MJ, Jirgensons A. (2021) Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. Proc Natl Acad Sci U S A, 118 (20). [PMID:33975947]

How to cite this page

Peptidases and proteinases (Plasmodium spp.): Plasmodium falciparum subtilisin-like protease 1. Last modified on 25/06/2021. Accessed on 27/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3184.