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S1: Chymotrypsin C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3189
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acrosin Show summary » More detailed page go icon to follow link

cathepsin G Show summary » More detailed page go icon to follow link

chymase 1 Show summary » More detailed page go icon to follow link

chymotrypsin C Show summary » More detailed page go icon to follow link

chymotrypsin like Show summary » More detailed page go icon to follow link

chymotrypsin like elastase 1 Show summary » More detailed page go icon to follow link

chymotrypsin like elastase 2A Show summary » More detailed page go icon to follow link

chymotrypsinogen B1 Show summary »

complement C1r C Show summary » More detailed page go icon to follow link

complement C1s Show summary » More detailed page go icon to follow link

complement factor B Show summary » More detailed page go icon to follow link

coagulation factor II, thrombin / prothrombin C Show summary » More detailed page go icon to follow link

coagulation factor VII Show summary » More detailed page go icon to follow link

coagulation factor IX Show summary » More detailed page go icon to follow link

coagulation factor X C Show summary » More detailed page go icon to follow link

coagulation factor XI C Show summary » More detailed page go icon to follow link

coagulation factor XII Show summary » More detailed page go icon to follow link

elastase, neutrophil expressed C Show summary » More detailed page go icon to follow link

granzyme A Show summary » More detailed page go icon to follow link

granzyme B Show summary » More detailed page go icon to follow link

granzyme K Show summary » More detailed page go icon to follow link

HtrA serine peptidase 1 Show summary »

kallikrein B1 Show summary » More detailed page go icon to follow link

kallikrein 1 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 2 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 3 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 4 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 5 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 6 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 7 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 8 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 14 Show summary » More detailed page go icon to follow link

plasminogen C Show summary » More detailed page go icon to follow link

plasminogen activator, tissue type C Show summary » More detailed page go icon to follow link

plasminogen activator, urokinase Show summary » More detailed page go icon to follow link

serine protease 1 C Show summary » More detailed page go icon to follow link

serine protease 2 Show summary » More detailed page go icon to follow link

serine protease 3 Show summary » More detailed page go icon to follow link

serine protease 8 Show summary » More detailed page go icon to follow link

protein C, inactivator of coagulation factors Va and VIIIa Show summary » More detailed page go icon to follow link

proteinase 3 Show summary » More detailed page go icon to follow link

ST14 transmembrane serine protease matriptase Show summary » More detailed page go icon to follow link

transmembrane serine protease 2 C Show summary » More detailed page go icon to follow link

transmembrane serine protease 6 Show summary » More detailed page go icon to follow link

transmembrane serine protease 11D Show summary » More detailed page go icon to follow link

transmembrane serine protease 15 Show summary »


Target Id 3189
Nomenclature transmembrane serine protease 15
Previous and unofficial names enterokinase | enteropeptidase | PRSS7
Genes TMPRSS15 (Hs), Tmprss15 (Mm), Tmprss15 (Rn)
Ensembl ID ENSG00000154646 (Hs), ENSMUSG00000022857 (Mm), ENSRNOG00000001916 (Rn)
UniProtKB AC P98073 (Hs), P97435 (Mm)
EC number
3.4.21.9
Inhibitors
sucunamostat pIC50 8.3 [27] - Rat
sucunamostat pIC50 8.3 [27]
Comment TMPRSS15 (enteropeptidase, enterokinase) is a transmembrane serine protease that is expressed in the duodenum brush border. It catalyses the conversion of the pancreatic proenzyme trypsinogen to trypsin, and is required for protein digestion and energy homeostasis. Selective enteropeptidase inhibiton is proposed as a novel strategy for correcting metabolic diseases and obesity [27,35,44].

tryptase alpha/beta 1 C Show summary » More detailed page go icon to follow link

tryptase gamma 1 Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

S1: Chymotrypsin. Accessed on 28/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=751.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.