2.6.1.42 Branched-chain-amino-acid transaminase

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2.6.1.42 Branched-chain-amino-acid transaminase

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3210

branched chain amino acid transaminase 1 Show summary »« Hide summary

Target Id

3210

Nomenclature

branched chain amino acid transaminase 1

Previous and unofficial names

BCATc | branched chain aminotransferase 1, cytosolic

Genes

BCAT1 (Hs), Bcat1 (Mm), Bcat1 (Rn)

Ensembl ID

ENSG00000060982 (Hs), ENSMUSG00000030268 (Mm), ENSRNOG00000015514 (Rn)

UniProtKB AC

P54687 (Hs), P54690 (Rn)

EC number

2.6.1.42

Inhibitors

BAY-069 pIC₅₀ 7.5 [1]

Comment

BCAT1 encodes the cytosolic form branched-chain amino acid transaminase.

branched chain amino acid transaminase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2893

Nomenclature

branched chain amino acid transaminase 2

Previous and unofficial names

Genes

BCAT2 (Hs), Bcat2 (Mm), Bcat2 (Rn)

Ensembl ID

ENSG00000105552 (Hs), ENSMUSG00000030826 (Mm), ENSRNOG00000020956 (Rn)

UniProtKB AC

O15382 (Hs), O35855 (Mm), O35854 (Rn)

EC number

2.6.1.42
L-leucine + 2-oxoglutarate <=> 4-methyl-2-oxopentanoate + L-glutamate L-isoleucine + 2-oxoglutarate <=> (S)-3-methyl-2-oxopentanoate + L-glutamate L-valine + 2-oxoglutarate <=> 3-methyl-2-oxobutanoate + L-glutamate

References

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How to cite this family page

Database page citation:

2.6.1.42 Branched-chain-amino-acid transaminase. Accessed on 27/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=926.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.