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CTP synthase 2

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Target not currently curated in GtoImmuPdb

Target id: 3216

Nomenclature: CTP synthase 2

Family: Nucleotide turnover

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 586 Xp22.2 CTPS2 CTP synthase 2
Mouse - 586 X F4 Ctps2 cytidine 5'-triphosphate synthase 2
Rat - 586 Xq14 Ctps2 CTP synthase 2
Previous and Unofficial Names Click here for help
cytidine 5'-triphosphate synthase 2 | CTP synthase II
Database Links Click here for help
Alphafold
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human CTPS2 bound to inhibitor T35
PDB Id:  7MII
Ligand:  compound 27 [PMID: 36449304]
Resolution:  2.7Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 6.3.4.2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pIC50 2
pIC50 7.7 (IC50 1.8x10-8 M) [2]
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 7.6 pIC50 2
pIC50 7.6 (IC50 2.3x10-8 M) [2]
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm Inhibition 7.5 pIC50 2
pIC50 7.5 (IC50 3.3x10-8 M) [2]
View species-specific inhibitor tables

References

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1. Lynch EM, DiMattia MA, Albanese S, van Zundert GCP, Hansen JM, Quispe JD, Kennedy MA, Verras A, Borrelli K, Toms AV et al.. (2021) Structural basis for isoform-specific inhibition of human CTPS1. Proc Natl Acad Sci U S A, 118 (40): e2107968118. [PMID:34583994]

2. Novak A, Laughton D, Lane R, Blackham E, Thomas J, Chatzopoulou E, Wrigglesworth J, Quddus A, Ahmed S, Cousin D et al.. (2022) Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem, 65 (24): 16640-16650. [PMID:36449304]

How to cite this page

Nucleotide turnover: CTP synthase 2. Last modified on 06/01/2023. Accessed on 23/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3216.