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| Quaternary Structure: Subunits |
| DNA topoisomerase 4 subunit A |
| DNA topoisomerase 4 subunit B |
| Quaternary Structure Comments |
| DNA topoisomerase 4 is a tetrameric enzyme, consisting of DNA topoisomerase 4 A (parC) and B (parE) subunits assembled into an A2B2 complex. |
Previous and Unofficial Names  |
| Topoisomerase IV | Topo IV |
| Database Links |
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| ChEMBL Target | CHEMBL2363076 (E.coli) |
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| General Comments |
| DNA topoisomerase 4 (also know as Topoisomerase IV) is a Type II DNA topoisomerase [1-2]. It is one of two enzymes of this subclass found in bacteria, the other being DNA gyrase. DNA topoisomerase 4 decatenates interlinked daughter chromosomes following DNA replication [3]. It catalyzes ATP-dependent breakage, passage and rejoining of double-stranded DNA. |
1. Kato J, Nishimura Y, Imamura R, Niki H, Hiraga S, Suzuki H. (1990) New topoisomerase essential for chromosome segregation in E. coli. Cell, 63 (2): 393-404. [PMID:2170028]
2. Kato J, Suzuki H, Ikeda H. (1992) Purification and characterization of DNA topoisomerase IV in Escherichia coli. J Biol Chem, 267 (36): 25676-84. [PMID:1334483]
3. Zechiedrich EL, Khodursky AB, Cozzarelli NR. (1997) Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes Dev, 11 (19): 2580-92. [PMID:9334322]
Bacterial protein targets: DNA topoisomerase 4. Last modified on 04/08/2023. Accessed on 28/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3227.
