TEAD (transcriptional enhanced associate domain) transcription factors

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TEAD (transcriptional enhanced associate domain) transcription factors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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There are four human genes that encode TEA domain transcription factors, TEAD1-4. The TEAD TFs bind to YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) proteins, which are downstream effectors of Hippo pathway signalling. The Hippo pathway is frequently activated in tumours, and this abberant activity drives proliferation and survival of cancer cells. Disruption of the interaction between TEADs and YAP/TAZ is a current approach for anti-tumour drug development [1].

Targets

3243

TEAD1 (TEA domain transcription factor 1) Show summary »« Hide summary

Target Id

3240

Nomenclature

TEA domain transcription factor 1

Common abbreviation

TEAD1

Previous and unofficial names

TEF-1 | transcriptional enhancer factor 1 | TCF13

Genes

TEAD1 (Hs), Tead1 (Mm), Tead1 (Rn)

Ensembl ID

ENSG00000187079 (Hs), ENSMUSG00000055320 (Mm), ENSRNOG00000015488 (Rn)

UniProtKB AC

P28347 (Hs)

Inhibitors

GNE-7883 (Binding) pIC₅₀ 7.4 [1], 7.3 [1]

TEAD2 (TEA domain transcription factor 2) Show summary »« Hide summary

TEAD3 (TEA domain transcription factor 3) Show summary »« Hide summary

TEAD4 (TEA domain transcription factor 4) Show summary »« Hide summary

Target Id

3243

Nomenclature

TEA domain transcription factor 4

Common abbreviation

TEAD4

Previous and unofficial names

EFTR-2 | TEF-3 | TEFR-1

Genes

TEAD4 (Hs), Tead4 (Mm), Tead4 (Rn)

Ensembl ID

ENSG00000197905 (Hs), ENSMUSG00000030353 (Mm), ENSRNOG00000005608 (Rn)

UniProtKB AC

Q15561 (Hs), P70282 (Mm)

Inhibitors

GNE-7883 (Binding) pIC₅₀ 7.5 [1], 7.5 [1]

References

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How to cite this family page

Database page citation:

TEAD (transcriptional enhanced associate domain) transcription factors. Accessed on 27/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1085.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.