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target has curated data in GtoImmuPdb
Target id: 3289
Nomenclature: glutaminyl-peptide cyclotransferase like
Family: M28: Aminopeptidase Y
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 382 | 19q13.32 | QPCTL | glutaminyl-peptide cyclotransferase like | |
Mouse | 1 | 383 | 7 9.46 cM | Qpctl | glutaminyl-peptide cyclotransferase-like | |
Rat | 1 | 383 | 1q21 | Qpctl | glutaminyl-peptide cyclotransferase-like |
Previous and Unofficial Names ![]() |
Golgi QC (gQC) | isoQC |
Database Links ![]() |
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Specialist databases | |
MEROPS | M28.016 |
Other databases | |
Alphafold | Q9NXS2 (Hs), Q9D8T5 (Mm) |
BRENDA | 2.3.2.5 |
Ensembl Gene | ENSG00000011478 (Hs), ENSMUSG00000030407 (Mm), ENSRNOG00000015413 (Rn) |
Human Protein Atlas | ENSG00000011478 (Hs) |
KEGG Enzyme | 2.3.2.5 |
Pharos | Q9NXS2 (Hs) |
UniProtKB | Q9NXS2 (Hs), Q9D8T5 (Mm) |
Wikipedia | QPCTL (Hs) |
Enzyme Reaction ![]() |
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Substrates and Reaction Kinetics ![]() |
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Golgi-resident glutaminyl cyclase (gQC, or isoQC) appears to influence the regulation of macrophages and monocytes and anti-tumour immunity in the tumour microenvironment [1]. Small molecule gQC inhibitors offer an approach to promote tumour-specific immunity. |
1. Bresser K, Logtenberg MEW, Toebes M, Proost N, Sprengers J, Siteur B, Boeije M, Kroese LJ, Schumacher TN. (2022) QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment. Oncoimmunology, 11 (1): 2049486. [PMID:35309731]
2. Mou J, Ning XL, Wang XY, Hou SY, Meng FB, Zhou C, Wu JW, Li C, Jia T, Wu X et al.. (2024) X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J Med Chem, 67 (11): 8730-8756. [PMID:38817193]
3. Yu L, Zhao P, Sun Y, Zheng Z, Du W, Zhang L, Li Y, Xie L, Xu S, Wang P. (2023) Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy. Signal Transduct Target Ther, 8 (1): 454. [PMID:38097557]
M28: Aminopeptidase Y: glutaminyl-peptide cyclotransferase like. Last modified on 04/06/2024. Accessed on 15/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3289.