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Rho GEFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

3338
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SOS Ras/Rac guanine nucleotide exchange factor 1 Show summary » More detailed page go icon to follow link

vav guanine nucleotide exchange factor 1 Show summary »

Target Id 3338
Nomenclature vav guanine nucleotide exchange factor 1
Previous and unofficial names vav 1 guanine nucleotide exchange factor | vav 1 oncogen
Genes VAV1 (Hs), Vav1 (Mm), Vav1 (Rn)
Ensembl ID ENSG00000141968 (Hs), ENSMUSG00000034116 (Mm), ENSRNOG00000050430 (Rn)
UniProtKB AC P15498 (Hs), P27870 (Mm), P54100 (Rn)
Ligands
MRT-6160 (Binding) (Molecular glue degrader) [2]
NGT-201-12 (Binding) (Molecular glue degrader) [1]
Comment The VAV1 protein is a hematopoietic-specific signaling protein that plays key regulatory functions in immune cell development and function. It acts as a guanine nucleotide exchange factor (GEF) for Rho/Rac family GTPases and as an adaptor/scaffold protein. Dysregulated VAV1 activity has been linked to hematological malignancies (e.g., T-cell lymphomas) and autoimmune diseases and it is therefore being pursued as a therapeutic target. Targeted degradation of VAV1 protein modulates both T- and B-cell receptor-mediated activity in vitro and in vivo, and disrupts cytokine secretion and immune signaling [2].

References

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How to cite this family page

Database page citation:

Rho GEFs. Accessed on 13/03/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1025.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.