STAT transcription factors

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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STAT family transcription factor proteins are phosphorylated by receptor kinases that are the receptors for cytokines and growth factors. Homo- or heterodimer phospho-STATs then translocate to the nucleus to regulate transcription of responsive genes.

Targets

3339

signal transducer and activator of transcription 1 Show summary »« Hide summary

Target Id

3339

Nomenclature

signal transducer and activator of transcription 1

Previous and unofficial names

ISGF-3 | STAT91 | transcription factor ISGF-3 components p91/p84

Genes

STAT1 (Hs), Stat1 (Mm), Stat1 (Rn)

Ensembl ID

ENSG00000115415 (Hs), ENSMUSG00000026104 (Mm), ENSRNOG00000014079 (Rn)

UniProtKB AC

P42224 (Hs), P42225 (Mm)

Inhibitors

ZDZ-553 pIC₅₀ 6.1 [3]

Comment

STAT1-mediated transcription is induced by ligands including IFN-α, IFN-γ, EGF, PDGF and IL-6. It is involved in the metabolic regulation and progression of inflammatory responses. Obesity-driven STAT1 signaling in the liver has been linked to metabolic dysfunction-associated steatohepatitis (MASH).

STAT3 (signal transducer and activator of transcription 3) Show summary »« Hide summary More detailed page go icon to follow link

signal transducer and activator of transcription 5A Show summary »« Hide summary

Target Id

3221

Nomenclature

signal transducer and activator of transcription 5A

Genes

STAT5A (Hs), Stat5a (Mm), Stat5a (Rn)

Ensembl ID

ENSG00000126561 (Hs), ENSMUSG00000004043 (Mm), ENSRNOG00000019496 (Rn)

UniProtKB AC

P42229 (Hs), P42230 (Mm), Q62771 (Rn)

Ligands

AK-2292 (Binding) pK_i 6.7 (PROTAC degrader) [1]

Inhibitors

compound (±)-2 [PMID: 41108282] pK_d 6.1 [2]

Comment

A transcription factor of the JAK-STAT signaling network that regulates the cellular response to cytokines and other extracellular signaling molecules. STAT5A is involved in a variety of physiological processes such as proliferation, differentiation, apoptosis, and immune system regulation.

STAT6 (signal transducer and activator of transcription 6) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2993
Nomenclature	signal transducer and activator of transcription 6
Common abbreviation	STAT6
Previous and unofficial names	IL-4 STAT \| interleukin-4-induced transcription factor
Genes	STAT6 (Hs), Stat6 (Mm), Stat6 (Rn)
Ensembl ID	ENSG00000166888 (Hs), ENSMUSG00000002147 (Mm), ENSRNOG00000025023 (Rn)
UniProtKB AC	P42226 (Hs), P52633 (Mm)

References

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1. Kaneshige A, Bai L, Wang M, McEachern D, Meagher JL, Xu R, Kirchhoff PD, Wen B, Sun D, Stuckey JA et al.. (2023) Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J Med Chem, 66 (4): 2717-2743. [PMID:36735833]

2. Liao J, Li X, Fan C, Yuan X, Zhang P, Wang D, Peng Y, Yang Y. (2025) Discovery of a Natural Small-Molecule Inhibitor to Novel Target STAT5A for Ischemic Stroke Therapy. J Med Chem, 68 (21): 22799-22817. [PMID:41108282]

3. Zhang Z, Lai H, Tian S, Song Y, Na C, Shi X, He C, Shi L, Wang S, Ali F et al.. (2026) Design, Synthesis, and Biological Evaluation of Chromone Derivatives as STAT1 Inhibitors for Treatment of Nonalcoholic Steatohepatitis. J Med Chem, 69 (3): 2509-2538. [PMID:41589317]

4. Zhang Z, Liao Y, Zhang J, Li Q, Feng Y, Yu W. (2025) Discovery of Juglone Derivatives as Novel STAT3 Inhibitors with Potent Suppression of Cancer Cell Stemness against Breast Cancer. J Med Chem, 68 (14): 15085-15109. [PMID:40637021]

How to cite this family page

Database page citation:

STAT transcription factors. Accessed on 12/03/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=990.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.