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EP2 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 341

Nomenclature: EP2 receptor

Family: Prostanoid receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 358 14q22.1 PTGER2 prostaglandin E receptor 2 77
Mouse 7 362 14 22.68 cM Ptger2 prostaglandin E receptor 2 (subtype EP2) 47
Rat 7 357 15p14 Ptger2 prostaglandin E receptor 2 19,66
Previous and Unofficial Names Click here for help
PGE receptor EP2 subtype | prostanoid EP2 receptor | Ptger-ep2 | prostaglandin E receptor 2 (subtype EP2), 53kDa
Database Links Click here for help
Specialist databases
GPCRdb pe2r2_human (Hs), pe2r2_mouse (Mm), pe2r2_rat (Rn)
Other databases
Alphafold
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
PGD2
PGE1
PGE2
PGF
PGI2
Comments: PGE2 is the principal endogenous agonist
Potency order of endogenous ligands
PGE2 = PGE1 > PGF, PGI2 > PGD2, thromboxane A2

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]PGE2 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Rn Full agonist 7.8 – 8.3 pKd 19,66
pKd 7.8 – 8.3 [19,66]
[3H]PGE2 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Hs Full agonist 7.7 – 7.9 pKd 1,102
pKd 7.7 – 7.9 (Kd 1.99x10-8 – 1.25x10-8 M) [1,102]
[3H]PGE2 Small molecule or natural product Ligand is labelled Ligand is radioactive Ligand has a PDB structure Mm Full agonist 7.7 pKd 92
pKd 7.7 [92]
ONO-AE1-259 Small molecule or natural product Mm Full agonist 8.5 pKi 95
pKi 8.5 [95]
omidenepag Small molecule or natural product Approved drug Hs Agonist 8.4 pKi 51
pKi 8.4 (Ki 3.6x10-9 M) [51]
treprostinil Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 8.4 pKi 96,101
pKi 8.4 [96,101]
PGN-9856 Small molecule or natural product Hs Agonist 8.3 pKi 24
pKi 8.3 [24]
PGE2 Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Rn Full agonist 8.2 pKi 19
pKi 8.2 [19]
PGE1 Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 8.0 pKi 13
pKi 8.0 (Ki 9.1x10-9 M) [13]
PGE1 Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Mm Full agonist 8.0 pKi 52
pKi 8.0 [52]
PGE1 Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Rn Full agonist 8.0 pKi 19
pKi 8.0 [19]
PGE2 Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 7.5 – 8.3 pKi 1,88,102
pKi 7.5 – 8.3 (Ki 3.16x10-8 – 5.01x10-9 M) [1,88,102]
16,16-dimethyl-PGE2 Small molecule or natural product Click here for species-specific activity table Mm Full agonist 7.8 pKi 52
pKi 7.8 [52]
PGE2 Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Mm Full agonist 7.4 – 7.9 pKi 52,91,95
pKi 7.4 – 7.9 [52,91,95]
11-deoxy-PGE1 Small molecule or natural product Click here for species-specific activity table Rn Full agonist 7.5 pKi 19
pKi 7.5 [19]
misoprostol (free acid form) Small molecule or natural product Click here for species-specific activity table Hs Full agonist 7.5 pKi 1
pKi 7.5 [1]
11-deoxy-PGE1 Small molecule or natural product Click here for species-specific activity table Mm Full agonist 7.3 pKi 52
pKi 7.3 [52]
butaprost (free acid form) Small molecule or natural product Click here for species-specific activity table Rn Full agonist 7.2 pKi 19
pKi 7.2 [19]
19(R)-OH-PGE2 Small molecule or natural product Click here for species-specific activity table Rn Full agonist 6.8 pKi 19
pKi 6.8 [19]
AH13205 Small molecule or natural product Mm Full agonist 6.6 pKi 52
pKi 6.6 [52]
butaprost (free acid form) Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.9 – 7.0 pKi 1,88
pKi 5.9 – 7.0 [1,88]
rivenprost Small molecule or natural product Click here for species-specific activity table Mm Full agonist 6.2 pKi 109
pKi 6.2 [109]
17-phenyl-ω-trinor-PGE2 Small molecule or natural product Click here for species-specific activity table Rn Full agonist 6.1 pKi 19
pKi 6.1 [19]
carbacyclin Small molecule or natural product Click here for species-specific activity table Hs Full agonist 6.0 pKi 1
pKi 6.0 [1]
AH13205 Small molecule or natural product Hs Full agonist 6.0 pKi 88
pKi 6.0 [88]
isocarbacyclin Small molecule or natural product Click here for species-specific activity table Mm Full agonist 6.0 pKi 52
pKi 6.0 [52]
iloprost Small molecule or natural product Approved drug Click here for species-specific activity table Immunopharmacology Ligand Rn Full agonist 5.9 pKi 19
pKi 5.9 [19]
MB-28767 Small molecule or natural product Click here for species-specific activity table Rn Full agonist 5.9 pKi 19
pKi 5.9 [19]
cicaprost Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Mm Full agonist 5.9 pKi 52
pKi 5.9 [52]
19(R)-OH-PGE2 Small molecule or natural product Hs Full agonist 5.9 pKi 77
pKi 5.9 [77]
carbacyclin Small molecule or natural product Click here for species-specific activity table Mm Full agonist 5.8 pKi 52
pKi 5.8 [52]
iloprost Small molecule or natural product Approved drug Click here for species-specific activity table Immunopharmacology Ligand Mm Full agonist 5.8 pKi 52
pKi 5.8 [52]
iloprost Small molecule or natural product Approved drug Click here for species-specific activity table Immunopharmacology Ligand Hs Full agonist 5.7 pKi 1
pKi 5.7 [1]
ONO-AE1-329 Small molecule or natural product Click here for species-specific activity table Mm Full agonist 5.7 pKi 95
pKi 5.7 [95]
MB-28767 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.3 – 6.0 pKi 1,88
pKi 5.3 – 6.0 [1,88]
PGF Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 5.2 – 6.0 pKi 1,88
pKi 5.2 – 6.0 [1,88]
PGF Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Rn Full agonist 5.6 pKi 19
pKi 5.6 [19]
ONO-AE-248 Small molecule or natural product Click here for species-specific activity table Mm Full agonist 5.4 pKi 95
pKi 5.4 [95]
PGD2 Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Rn Full agonist 5.3 pKi 19
pKi 5.3 [19]
MRE-269 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 5.2 pKi 56
pKi 5.2 (Ki 5.8x10-6 M) [56]
U46619 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Rn Full agonist 5.1 pKi 19
pKi 5.1 [19]
PGD2 Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Full agonist 5.0 pKi 88
pKi 5.0 [88]
misoprostol (methyl ester) Small molecule or natural product Approved drug Click here for species-specific activity table Hs Full agonist 5.0 pKi 1
pKi 5.0 [1]
U46619 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 4.9 pKi 1
pKi 4.9 [1]
evatanepag Small molecule or natural product Ligand has a PDB structure Rn Full agonist 9.5 pEC50 21
pEC50 9.5 (EC50 3x10-10 M) [21]
taprenepag Small molecule or natural product Ligand has a PDB structure Rn Full agonist 8.3 pIC50 74
pIC50 8.3 [74]
taprenepag Small molecule or natural product Ligand has a PDB structure Hs Full agonist 8.0 pIC50 74
pIC50 8.0 [74]
evatanepag Small molecule or natural product Ligand has a PDB structure Rn Full agonist 7.3 pIC50 21
pIC50 7.3 (IC50 5.01x10-8 M) [21]
View species-specific agonist tables
Agonist Comments
ONO-AE1-259 is the agonist of choice for selectively activating the EP2 receptor.

Butaprost and misoprostol may require enzymatic hydolysis of their ester moiety to achieve full bioactivity.

CP-533536 is a non prostanoid EP2 receptor agonist.

CP-544336 is the biologically-active metabolite of PF-04217329 (Taprenepag isopropyl) [74].

Another non-prostanoid EP2 agonist, o-(o-benzyloxy)-cinnamyl)-cinnamic acid [15], has very slow onset/offset of action on isolated tissue preparations, apparently due to its high lipophilicity [44].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TG4-155 Small molecule or natural product Hs Antagonist 8.6 pKB 41
pKB 8.6 TG4-155 also has affinity for the human DP1 receptor (pKb = 7.8) [41]
TG7-171 Small molecule or natural product Hs Antagonist 8.6 pKB 31
pKB 8.6 (KB 2.69x10-9 M) [31]
PF-04852946 Small molecule or natural product Hs Antagonist 8.4 – 8.5 pKB 49
pKB 8.4 – 8.5 (KB 3.55x10-9 – 2.95x10-9 M) [49]
PF-04418948 Small molecule or natural product Immunopharmacology Ligand Mm Antagonist 8.3 pKB 17
pKB 8.3 [17]
PF-04418948 Small molecule or natural product Immunopharmacology Ligand Hs Antagonist 8.3 pKB 3,17
pKB 8.3 PF-04418948 has weaker affinity at the EP2-receptor in guinea-pigs [3,17]
TG6-129 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 8.1 pKB 32
pKB 8.1 (KB 8.8x10-9 M) [32]
TG11-77 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 8.0 pKB 5
pKB 8.0 (KB 9.7x10-9 M) [5]
TG8-260 Small molecule or natural product Immunopharmacology Ligand Hs Antagonist 7.9 pKB 6,76
pKB 7.9 [6,76]
AH6809 Small molecule or natural product Immunopharmacology Ligand Mm Antagonist 6.5 pKi 52
pKi 6.5 [52]
AH6809 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Rn Antagonist 6.3 pKi 19
pKi 6.3 [19]
AH6809 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 5.9 pKi 1
pKi 5.9 [1]
View species-specific antagonist tables
Antagonist Comments
The weak, non-selective EP2 receptor antagonist, AH-6809, has been superceded by PF-04418948. Currently, PF-04418948 is the antagonist of choice for defining EP2 receptor-mediated responses.
PF-04418948 has a lower affinity (pKB = 6.95) for the guinea-pig EP2 receptor compared to the human and murine orthologues [17].
TG4-155 also has high affinity for the DP1 receptor [40-41].
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1 [PMID: 20080612] Small molecule or natural product Hs Positive - - 42
[42]
Allosteric Modulator Comments
Allosteric modulators- both positive (2-piperidinyl phenyl benzamide or trisubstituted pyrimidine core) and negative (compound 1: PubChem CID 664888)- have been identified for the human EP2 receptor (Jiang et al., 2010 [42], 2018 [43], 2020 [39]).
Immunopharmacology Comments
Foudi et al. (2012) [28] review the presence and role of EP1-4 receptors in human inflammation and immune cells. EP2 receptor is discussed in this review of immuno-oncology [2].

PGE2, acting via EP2 and EP4 receptors in synovial tissue appears to contribute to the progression of rheumatoid arthritis in a rat model [105].
Immuno Process Associations
Immuno Process:  Inflammation
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family Adenylyl cyclase stimulation
References:  84,91
Tissue Distribution Click here for help
Small intestine, lung, kidney, thymus, uterus and brain.
Species:  Human
Technique:  Northern blot.
References:  13
Kidney: media of arteries, media of arterioles.
Species:  Human
Technique:  Immunohistochemistry.
References:  64
Eye: sclera.
Species:  Human
Technique:  Immunocytochemistry and RT-PCR.
References:  7
Penis: corpus cavernosum.
Species:  Human
Technique:  RT-PCR and Immunohistochemistry.
References:  54
Mouth: gingival fibroblasts.
Species:  Human
Technique:  RT-PCR.
References:  67
Eye: corneal epithelium and choriocapillaries.
Species:  Human
Technique:  Immunohistochemistry.
References:  83
Myometrial cells.
Species:  Human
Technique:  Immunocytochemistry.
References:  65
Eosinophils.
Species:  Human
Technique:  Immunocytochemistry.
References:  89
Monocyte-derived dendritic cells.
Species:  Human
Technique:  RT-PCR.
References:  55
Aorta.
Species:  Human
Technique:  RT-PCR.
References:  14
Articular cartilage.
Species:  Human
Technique:  RT-PCR and Immunohistochemistry.
References:  8
Airway smooth muscle cells.
Species:  Human
Technique:  RT-PCR, immunocytochemistry.
References:  23
Airway epithelial cells.
Species:  Human
Technique:  RT-PCR.
References:  33
Peritoneal neutrophils.
Species:  Mouse
Technique:  Northern blot.
References:  106
Spinal cord.
Species:  Rat
Technique:  RT-PCR.
References:  48
Forebrain: meninges, ependymal layer of the lateral ventricle, hippocampus (dentate gyrus, CA1-3), lateral septal nucleus, subfornical organ, piriform cortex, bed nuclei stria terminalis, amygdala, hypothalamus (periventricular zone, ventromedial nucleus), thalamus.
Brainstem: locus coeruleus, area postrema.
Cerebellum: Purkinje cell layers.
Species:  Rat
Technique:  in situ hybridisation.
References:  111
Proximal caput epididymidis.
Species:  Rat
Technique:  RT-PCR and Northern Blotting.
References:  36
Lung, spleen, intestine, skin, kidney, liver, long bone.
Species:  Rat
Technique:  RT-PCR
References:  66
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in non-pigmented epithelial (NPE) cells endogenously expressing the EP2 receptor.
Species:  Human
Tissue:  Non-pigmented epithelial (NPE) cells.
Response measured:  Stimulation of cAMP accumulation.
References:  45
Measurement of cAMP levels in COS-7 cells transfected with the human EP2 receptor.
Species:  Human
Tissue:  COS-7 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  77
Measurement of cAMP levels in COS-7 cells transfected with the rat EP2 receptor.
Species:  Rat
Tissue:  COS-7 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  66
Measurement of cAMP levels in CHO cells transfected with the human EP2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  70,103
Measurement of neuronal excitability in rat spinal cord slices endogenously expressing the EP2 receptor.
Species:  Rat
Tissue:  Spinal cord slices.
Response measured:  Depolarisation of neurons.
References:  12
Measurement of Cl- current in rat osteoclasts endogenously expressing the EP2 receptor.
Species:  Rat
Tissue:  Osteoclasts.
Response measured:  Stimulation of Cl- current.
References:  71
Measurement of T-cell factor (Tcf)/lymphoid enhancer factor (Lef) signalling in HEK 293 cells transfected with the human EP2 receptor using a Tcf/Lef-responsive luciferase reporter gene. In addition, measurement of the phosphorylation of glycogen synthase kinase-3 (GSK-3) and Akt kinase.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Activation of Tcf/Lef signalling via a PKA-dependent pathway, phosphorylation of GSK-3 and Akt kinase.
References:  29
Measurement of cAMP formation in cells over-expressing the EP2 receptor.
Species:  Human
Tissue:  C6 glioma cells.
Response measured:  Reduction in TR-FRET signal (Cisbio Bioassay).
References:  41
Physiological Functions Click here for help
Relaxation of bronchial smooth muscle.
Species:  Human
Tissue:  Bronchial preparations.
References:  68
Bronchodilation.
Species:  Mouse
Tissue:  In vivo.
References:  27,86,100
Dilation of arterioles and venules.
Species:  Rat
Tissue:  Stomach.
References:  69
Blood pressure regulation (male and female).
Species:  Mouse
Tissue:  In vivo.
References:  11
Stimulation of renin release and renal vasodilation.
Species:  Mouse
Tissue:  In vivo.
References:  85
Downregulation of protease-activated receptors (PARs).
Species:  Human
Tissue:  Lung fibroblasts.
References:  87
Mediation of spinal inflammatory hyperalgesia.
Species:  Mouse
Tissue:  In vivo.
References:  78
Smooth muscle relaxation.
Species:  Rat
Tissue:  Pulmonary artery rings.
References:  30
Inhibition of sleep.
Species:  Rat
Tissue:  In vivo.
References:  110
Stimulation of calcitonin-gene related peptide (CGRP) release.
Species:  Rat
Tissue:  Primary cultures of trigeminal neurons.
References:  38
Apoptotic cell death.
Species:  Rat
Tissue:  Cortical cells.
References:  98
Bone formation.
Species:  Rat
Tissue:  In vivo.
References:  57,72
Stimulation of cell differentiation (simultaneously with EP4).
Species:  Rat
Tissue:  Primary chondrocytes.
References:  62
Reduction in osteoclast motility.
Species:  Rat
Tissue:  Osteoclasts.
References:  71
Inhibition of phagocytosis.
Species:  Rat
Tissue:  Alveolar macrophages.
References:  9
Apoptotic cell death.
Species:  Rat
Tissue:  Hippocampal cells.
References:  97
Promotion of cell growth.
Species:  Human
Tissue:  Articular chondrocytes.
References:  8
Follicle growth.
Species:  Rat
Tissue:  In vivo (ovary).
References:  25
Cumulus cell expansion in ovarian follicles.
Species:  Mouse
Tissue:  In vivo.
References:  35
Neuroprotection.
Species:  Rat
Tissue:  Hippocampal slices.
References:  61
Inhibition of TNFα formation.
Species:  Mouse
Tissue:  Kupffer cells.
References:  26
Inhibition of TNFα release.
Species:  Human
Tissue:  Alveolar macrophages.
References:  75
Reduction of intraocular pressure.
Species:  Human
Tissue:  Eye.
References:  82
Augementation of G-CSF secretion.
Species:  Human
Tissue:  Airway smooth muscle cells.
References:  23
Suppression of GM-CSF release.
Species:  Human
Tissue:  Airway smooth muscle cells.
References:  22
Relaxation.
Species:  Mouse
Tissue:  Tracheal smooth muscle.
References:  17
Carcinogenesis.
Species:  Human
Tissue:  Prostate cancer cell lines.
References:  40
Inhibition of migration.
Species:  Human
Tissue:  Airway smooth muscle cells.
References:  10
Inhibition of IL-12, IL-23, TNF-α, and MCP-1 release.
Species:  Human
Tissue:  Monocyte-derived dendritic cells.
References:  73
Inhibition of fibroblast to myofibroblast transition.
Species:  Human
Tissue:  Primary fetal and adult lung fibroblasts.
References:  53
Physiological Consequences of Altering Gene Expression Click here for help
EP2 receptor knockout mice exhibit an impaired hypercalcemic response to PGE2.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  59
EP2 receptor knockout mice exhibit impaired tumour angiogenesis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  46
Transgenic mice overexpressing the EP2 receptor exhibit increased keratinocyte proliferation and increased tumour development.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  94
EP2 receptor knockout mice exhibit weak bones.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  4
EP2 receptor knockout mice do not exhibit the bronchodilatory response to PGE2 seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  27,86,100
EP2 receptor knockout mice exhibit salt-sensitive hypertension in response to PGE2 and reduced fertility.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  50,99
EP2 receptor knockout mice exhibit reduced PGE2-induced vasodepression compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  11
EP2 receptor knockout mice exhibit PGE2-mediated renal vasoconstriction, in contrast to the vasodilation seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  37
EP2 receptor knockout mice exhibit an increase in mean arterial pressure, in contrast to a decrease in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  112
EP2 receptor knockout mice do not exhibit spinal PGE2-evoked hyperalgesia, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  78
EP2 receptor knockout mice exhibit resistance to the inhibitory effect of PGE2 on phagocytosis by alveolar macrophages.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  9
EP2 receptor knockout mice do not exhibit complete cumulus expansion and hence display impaired fertility.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  35
Osteoblasts from EP2 receptor knockout mice have an impaired ability to stimulate osteoclast formation.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  58
EP2 receptor knockout mice exhibit a protective effect against neuronal oxidative damage.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  63
EP2 receptor knockout mice exhibit a reduced increase in aqueous humour protein concentration in the eye and an inhibition of the disruption of the blood-aqueous barrier, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  16,18
EP2 receptor knockout mice subjected to permanent focal ischemia exhibit increased excitotoxicity compared to wild-type mice subjected to the same permanent focal ischemia.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  61
Peritoneal neutrophils from EP2 receptor knockout mice do not exhibit PGE2-mediated G-CSF (granulocyte colony-stimulating factor, a hemopoietic growth factor) release, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  90
Tracheal rings from EP2 receptor knockout mice appear to be resistant to cytokine-mediated β2-adrenoceptor desensitisation.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  34
EP2 receptor knockout mice exhibit reduced keratinocyte proliferation and reduced tumour development.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  93
Deletion of the EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness.
Species:  Mouse
Tissue:  Skin.
Technique:  Gene targeting in embryonic stem cells.
References:  20
A familial model of Alzheimer's disease deficient in the EP2-receptor displays a reduction in lipid peroxidation that is associated with decreases in amyloid beta peptides and amyloid deposition.
Species:  Mouse
Tissue:  Brain.
Technique:  Gene targeting in embryonic stem cells.
References:  60
Mediation of immune suppression in cancer.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  108
EP2 receptor agonists fail to reduce intraocular pressure in PTGER2-knockout mice.
Species:  Mouse
Tissue:  Eye.
Technique:  Gene knockouts.
References:  79
EP2 receptor knockout mice have higher systolic blood pressure when compared to wild-type mice.
Species:  Mouse
Tissue:  Cardiovascular system.
Technique:  Gene targeting in embryonic stem cells.
References:  75
EP2 receptor deficiency results in impaired cognition, sensorimotor gating, and hippocampal long-term depression.
Species:  Mouse
Tissue:  Brain.
Technique:  Gene targeting in embryonic stem cells.
References:  81
EP2 receptor deficiency impairs hippocampal long-term synaptic plasticity and cognition.
Species:  Mouse
Tissue:  Brain.
Technique:  Gene targeting in embryonic stem cells.
References:  107
EP2 receptor deficiency exacerbates vascular neointimal formation.
Species:  Mouse
Tissue:  Femoral artery.
Technique:  Gene targeting in embryonic stem cells.
References:  113
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0002334 abnormal airway responsiveness PMID: 10846038 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
MGI:97794  MP:0001562 abnormal circulating calcium level PMID: 12013525 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0009373 abnormal cumulus expansion PMID: 9751056 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
C.129S6-Ptger2
MGI:97794  MP:0002912 abnormal excitatory postsynaptic potential PMID: 19012750 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
C.129S6-Ptger2
MGI:97794  MP:0003691 abnormal microglial cell physiology PMID: 15793296 
Ptger2tm1Brey|Tg(APPswe,PSEN1dE9)85Dbo Ptger2tm1Brey/Ptger2tm1Brey,Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6
MGI:3525178  MGI:97794  MP:0003633 abnormal nervous system physiology PMID: 16267225 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * BALB/c
MGI:97794  MP:0003633 abnormal nervous system physiology PMID: 12423256 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0001125 abnormal oocyte morphology PMID: 10468638 
Ptger2tm1Rsz Ptger2tm1Rsz/Ptger2tm1Rsz
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0008396 abnormal osteoclast differentiation PMID: 10830290 
Ptger2tm2Bhk Ptger2tm2Bhk/Ptger2tm2Bhk
involves: 129P2/OlaHsd * 129S/SvEv
MGI:97794  MP:0005581 abnormal renin activity PMID: 10359563 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0005025 abnormal response to infection PMID: 17330822 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * BALB/c
MGI:97794  MP:0005025 abnormal response to infection PMID: 12423256 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
B6.129S6-Ptger2
MGI:97794  MP:0005164 abnormal response to injury PMID: 14715958 
Hrhr|Ptger2tm1Brey Hrhr/Hrhr,Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6 * SKH1
MGI:96223  MGI:97794  MP:0005501 abnormal skin physiology PMID: 16977324 
Hrhr|Ptger2+|Ptger2tm1Brey Hrhr/Hrhr,Ptger2tm1Brey/Ptger2+
involves: 129S6/SvEvTac * C57BL/6 * SKH1
MGI:96223  MGI:97794  MP:0005501 abnormal skin physiology PMID: 16977324 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
B6.129S6-Ptger2
MGI:97794  MP:0001463 abnormal spatial learning PMID: 19012750 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0009648 abnormal superovulation PMID: 11319164 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0001613 abnormal vasodilation PMID: 9930871 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac
MGI:97794  MP:0001613 abnormal vasodilation PMID: 12167591 
Hrhr|Ptger2tm1Brey Hrhr/Hrhr,Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6 * SKH1
MGI:96223  MGI:97794  MP:0003448 altered tumor morphology PMID: 16977324 
Ptger2tm1Brey|Tg(APPswe,PSEN1dE9)85Dbo Ptger2tm1Brey/Ptger2tm1Brey,Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6
MGI:3525178  MGI:97794  MP:0000604 amyloidosis PMID: 16267225 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0002680 decreased corpora lutea number PMID: 10468638 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac
MGI:97794  MP:0004502 decreased incidence of chemically-induced tumors PMID: 16886605 
Hrhr|Ptger2tm1Brey Hrhr/Hrhr,Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6 * SKH1
MGI:96223  MGI:97794  MP:0004504 decreased incidence of UV-induced tumors PMID: 16977324 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0001935 decreased litter size PMID: 9930871 
Ptger2tm2Bhk Ptger2tm2Bhk/Ptger2tm2Bhk
involves: 129P2/OlaHsd * 129S/SvEv
MGI:97794  MP:0001935 decreased litter size PMID: 10359563 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0001935 decreased litter size PMID: 10468638 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0003355 decreased ovulation rate PMID: 10468638 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac
MGI:97794  MP:0003447 decreased tumor growth/size PMID: 16886605 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0009374 failure of cumulus expansion PMID: 10468638 
Ptger2tm2Bhk Ptger2tm2Bhk/Ptger2tm2Bhk
involves: 129P2/OlaHsd * 129S/SvEv
MGI:97794  MP:0001596 hypotension PMID: 10359563 
Ptger2tm2Bhk Ptger2tm2Bhk/Ptger2tm2Bhk
involves: 129P2/OlaHsd * 129S/SvEv
MGI:97794  MP:0000242 impaired fertilization PMID: 10359563 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0000242 impaired fertilization PMID: 10468638 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
B6.129S6-Ptger2
MGI:97794  MP:0006060 increased cerebral infarction size PMID: 14715958 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0002842 increased systemic arterial blood pressure PMID: 9930871 
Hrhr|Ptger2tm1Brey Hrhr/Hrhr,Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6 * SKH1
MGI:96223  MGI:97794  MP:0003721 increased tumor growth/size PMID: 16977324 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac
MGI:97794  MP:0003025 increased vasoconstriction PMID: 12167591 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6
MGI:97794  MP:0001923 reduced female fertility PMID: 9930871 
Ptger2tm2Bhk Ptger2tm2Bhk/Ptger2tm2Bhk
involves: 129P2/OlaHsd * 129S/SvEv
MGI:97794  MP:0001923 reduced female fertility PMID: 10359563 
Ptger2tm1Sna Ptger2tm1Sna/Ptger2tm1Sna
involves: 129P2/OlaHsd * C57BL/6
MGI:97794  MP:0001923 reduced female fertility PMID: 10468638 
Ptger2tm1Brey Ptger2tm1Brey/Ptger2tm1Brey
C.129S6-Ptger2
MGI:97794  MP:0001473 reduced long term potentiation PMID: 19012750 
Biologically Significant Variants Click here for help
Type:  Naturally occurring SNPs
Species:  Human
Description:  rs17197 is a more frequent polymorphism in Japanese men with essential hypertension when compared to normotensive counterparts. Proposed to be a genetic marker of essential hypertension.
SNP accession: 
References:  80
General Comments
For futher information on the properties of the EP2 receptor and its ligands, see the the NC-IUPHAR sponsored review of Woodward et al, 2011 [104].

References

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