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Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 391 | 14q13 | SSTR1 | somatostatin receptor 1 | 55-56 |
| Mouse | 7 | 391 | 12 25.61 cM | Sstr1 | somatostatin receptor 1 | 55 |
| Rat | 7 | 391 | 6q23 | Sstr1 | somatostatin receptor 1 | 28 |
| Previous and Unofficial Names |
| SRIF-2 | SS1R |
| Database Links |
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| Specialist databases | |
| GPCRdb | ssr1_human (Hs), ssr1_mouse (Mm), ssr1_rat (Rn) |
| Other databases | |
| Alphafold | P30872 (Hs), P30873 (Mm), P28646 (Rn) |
| ChEMBL Target | CHEMBL1917 (Hs), CHEMBL4242 (Mm), CHEMBL4652 (Rn) |
| DrugBank Target | P30872 (Hs) |
| Ensembl Gene | ENSG00000139874 (Hs), ENSMUSG00000035431 (Mm), ENSRNOG00000048145 (Rn) |
| Entrez Gene | 6751 (Hs), 20605 (Mm), 25033 (Rn) |
| Human Protein Atlas | ENSG00000139874 (Hs) |
| KEGG Gene | hsa:6751 (Hs), mmu:20605 (Mm), rno:25033 (Rn) |
| OMIM | 182451 (Hs) |
| Pharos | P30872 (Hs) |
| RefSeq Nucleotide | NM_001049 (Hs), NM_009216 (Mm), NM_012719 (Rn) |
| RefSeq Protein | NP_001040 (Hs), NP_033242 (Mm), NP_036851 (Rn) |
| UniProtKB | P30872 (Hs), P30873 (Mm), P28646 (Rn) |
| Wikipedia | SSTR1 (Hs) |
| Natural/Endogenous Ligands |
| cortistatin-14 {Sp: Mouse, Rat} |
| CST-17 {Sp: Human} |
| SRIF-14 {Sp: Human, Mouse, Rat} |
| SRIF-28 {Sp: Human, Mouse, Rat} |
| Comments: SRIF-14 and SRIF-28 are the active fragments of precursor somatostatin |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immuno Process Associations | ||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | Adenylyl cyclase inhibition |
| References: 20,23,46 | |
| Secondary Transduction Mechanisms |
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| Transducer | Effector/Response |
| G protein (identity unknown) | Other - See Comments |
| Comments: PTX-insensitive G-proteins activate protein tyrosine phosphatases (PTPs) and the Na+/H+ exchanger (NHE1). | |
| References: 8,20,30 | |
| Tissue Distribution
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| Functional Assays
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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18. Helboe L, Stidsen CE, Moller M. (1998) Immunohistochemical and cytochemical localization of the somatostatin receptor subtype sst1 in the somatostatinergic parvocellular neuronal system of the rat hypothalamus. J Neurosci, 18 (13): 4938-45. [PMID:9634559]
19. Hervieu G, Emson PC. (1998) The localization of somatostatin receptor 1 (sst1) immunoreactivity in the rat brain using an N-terminal specific antibody. Neuroscience, 85 (4): 1263-84. [PMID:9681962]
20. Hou C, Gilbert RL, Barber DL. (1994) Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. J Biol Chem, 269 (14): 10357-62. [PMID:8144617]
21. Hoyer D, Nunn C, Hannon J, Schoeffter P, Feuerbach D, Schuepbach E, Langenegger D, Bouhelal R, Hurth K, Neumann P et al.. (2004) SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. Neurosci Lett, 361 (1-3): 132-5. [PMID:15135911]
22. Imhof AK, Glück L, Gajda M, Lupp A, Bräuer R, Schaible HG, Schulz S. (2011) Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum, 63 (8): 2352-62. [PMID:21506098]
23. Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lubbert H. (1993) Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. FEBS Lett, 331: 53-59. [PMID:8405411]
24. Kreienkamp HJ, Akgün E, Baumeister H, Meyerhof W, Richter D. (1999) Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett, 462 (3): 464-6. [PMID:10622746]
25. Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC. (1999) Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes, 48 (1): 77-85. [PMID:9892225]
26. Lambertini C, Barzaghi-Rinaudo P, D'Amato L, Schulz S, Nuciforo P, Schmid HA. (2013) Evaluation of somatostatin receptor subtype expression in human neuroendocrine tumors using two sets of new monoclonal antibodies. Regul Pept, 187: 35-41. [PMID:24188818]
27. Lanneau C, Viollet C, Faivre-Bauman A, Loudes C, Kordon C, Epelbaum J, Gardette R. (1998) Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study. Eur J Neurosci, 10 (1): 204-12. [PMID:9753128]
28. Li XJ, Forte M, North RA, Ross CA, Snyder SH. (1992) Cloning and expression of a rat somatostatin receptor enriched in brain. J Biol Chem, 267 (30): 21307-12. [PMID:1400442]
29. Liapakis G, Tallent M, Reisine T. (1996) Molecular and functional properties of somatostain receptor subtypes. Metab Clin Exp, 45 (8 Suppl 1): 12-3. [PMID:8769370]
30. Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber DL. (2003) Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem, 278 (17): 15128-35. [PMID:12566440]
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32. Mastrodimou N, Thermos K. (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in rat retina. Neurosci Lett, 356 (1): 13-6. [PMID:14746890]
33. Meyerhof W. (1998) The elucidation of somatostatin receptor functions: a current view. Rev Physiol Biochem Pharmacol, 133: 55-108. [PMID:9600011]
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51. Tulipano G, Soldi D, Bagnasco M, Culler MD, Taylor JE, Cocchi D, Giustina A. (2002) Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology, 143: 1218-1224. [PMID:11897676]
52. Unger N, Ueberberg B, Schulz S, Saeger W, Mann K, Petersenn S. (2012) Differential expression of somatostatin receptor subtype 1-5 proteins in numerous human normal tissues. Exp Clin Endocrinol Diabetes, 120 (8): 482-9. [PMID:22976314]
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54. Viollet C, Bodenant C, Prunotto C, Roosterman D, Schaefer J, Meyerhof W, Epelbaum J, Vaudry H, Leroux P. (1997) Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem, 68 (6): 2263-72. [PMID:9166718]
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56. Yamada Y, Stoffel M, Espinosa 3rd R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI. (1993) Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. Genomics, 15 (2): 449-52. [PMID:8449518]
57. Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW et al.. (1998) Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci USA, 95 (18): 10836-41. [PMID:9724791]
