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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 4 | 454 | 3q27.1 | HTR3D | 5-hydroxytryptamine receptor 3D | 2-3 |
| Previous and Unofficial Names |
| 5-HT3D | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic |
| Database Links |
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| Alphafold | Q70Z44 (Hs) |
| CATH/Gene3D | 2.70.170.10 |
| ChEMBL Target | CHEMBL2094132 (Hs) |
| Ensembl Gene | ENSG00000186090 (Hs) |
| Entrez Gene | 200909 (Hs) |
| Human Protein Atlas | ENSG00000186090 (Hs) |
| KEGG Gene | hsa:200909 (Hs) |
| OMIM | 610122 (Hs) |
| Pharos | Q70Z44 (Hs) |
| RefSeq Nucleotide | NM_182537 (Hs) |
| RefSeq Protein | NP_872343 (Hs) |
| UniProtKB | Q70Z44 (Hs) |
| Wikipedia | HTR3D (Hs) |
| Natural/Endogenous Ligands |
| 5-hydroxytryptamine |
| Tissue Distribution
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| General Comments |
| The 5-HT3D subunit is absent from the rodent genome [1-3]. The human 5-HT3D subunit does not function as a homomer [1,4]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3D subunit at the cell surface in one study [4], but not in a second [1]. Co-assembly of the 5-HT3A and 5-HT3D subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [4]. Co-expression of the 5-HT3D and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [1,4]. |
1. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP et al.. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem, 108 (2): 384-96. [PMID:19012743]
2. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW et al.. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]
3. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]
4. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol, 72 (1): 8-17. [PMID:17392525]
