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TPC1

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Target not currently curated in GtoImmuPdb

Target id: 392

Nomenclature: TPC1

Family: CatSper and Two-Pore channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 0 816 12q24.13 TPCN1 two pore segment channel 1
Mouse 12 0 817 5 F Tpcn1 two pore channel 1
Rat 12 0 817 12q16 Tpcn1 two pore segment channel 1
Previous and Unofficial Names Click here for help
two pore calcium channel protein 1 | two pore channel 1 | voltage-gated Ca channel
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics Click here for help
Organelle voltage-gated Na+-selective channel (Na+>>K+>>Ca2+); Required for the generation of action potential-like long depolarization in lysosomes. Voltage-dependence of activation is sensitive to luminal pH (determined from lysosomal recordings). ψ1/2 @ pH4.6 = +91 mV; ψ1/2 @ pH6.5 = +2.6 mV. Maximum activity requires PI(3,5)P2 and reduced [ATP], or depletion of extracellular amino acids.

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
phosphatidyl (3,5) inositol bisphosphate Small molecule or natural product Click here for species-specific activity table Hs Activation 6.5 pEC50 - - 1
pEC50 6.5 (EC50 3x10-7 M) [1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
verapamil Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 4.6 pIC50 - - 1
pIC50 4.6 (IC50 2.3x10-5 M) [1]
Cd2+ Click here for species-specific activity table Hs Inhibition 3.7 pIC50 - - 1
pIC50 3.7 (IC50 1.8x10-4 M) [1]

References

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1. Cang C, Bekele B, Ren D. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat. Chem. Biol., 10 (6): 463-9. [PMID:24776928]

Contributors

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