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GABAA receptor θ subunit

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Target not currently curated in GtoImmuPdb

Target id: 418

Nomenclature: GABAA receptor θ subunit

Family: GABAA receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 632 Xq28 GABRQ gamma-aminobutyric acid type A receptor subunit theta 1
Mouse 3 638 X A6 Gabrq gamma-aminobutyric acid (GABA) A receptor, subunit theta 3
Rat 4 635 Xq37 Gabrq gamma-aminobutyric acid type A receptor subunit theta 3
Previous and Unofficial Names Click here for help
gamma-aminobutyric acid receptor subunit theta | gamma-aminobutyric acid (GABA) A receptor, theta | gamma-aminobutyric acid (GABA) A receptor, subunit theta | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor theta subunit
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GABA

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent
Tissue Distribution Click here for help
Substantia nigra pars compacta, locus coeruleus
Species:  Human
Technique:  In situ hybridization and immunohistochemistry
References:  1
Locus coeruleus, centromedial thalamic region, hypothalamus (dorsomedial and ventromedial regions)
Species:  Rat
Technique:  In situ hybridisation
References:  3
Septum (ventral and intermediate nucleus), bed nuclei and the stria terminalis, amygdala (medial and central nuclei), dentate gyrus, preoptic areas, hypothalamus, thalamus, lateral geniculate nucleus, raphe nuclei, locus coeruleus
Species:  Rat
Technique:  In situ hybridisation
References:  2
Cerebral cortex (cingulate and piriform regions), olfactory tract, nucleus accumbens, hypothalamus (anterior and mammiliary body), amygdala, hippocampus, substantia nigra, pineal gland, pons, dorsal raphe, central grey
Species:  Monkey
Technique:  In situ hybridisation
References:  1
Hypothalamus, cortical pyramidal neurones, substantia nigra pars compacta and associated neurites of the pars reticulata, ventral and lateral tegmental areas, locus coeruleus, recticular pontine nuclei, dorsal raphe
Species:  Monkey
Technique:  Immunohistochemistry
References:  1

References

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1. Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. (1999) theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci USA, 96 (17): 9891-6. [PMID:10449790]

2. Moragues N, Ciofi P, Tramu G, Garret M. (2002) Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain. Neuroscience, 111 (3): 657-69. [PMID:12031352]

3. Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER. (2000) GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci, 20 (10): 3588-95. [PMID:10804200]

Contributors

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