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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 440 | 5q35.1 | GABRP | gamma-aminobutyric acid type A receptor subunit pi | 3 |
Mouse | 4 | 440 | 11 A4 | Gabrp | gamma-aminobutyric acid type A receptor subunit pi | 4 |
Rat | 4 | 440 | 10q12 | Gabrp | gamma-aminobutyric acid type A receptor subunit pi | 3 |
Database Links ![]() |
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Alphafold | O00591 (Hs), Q8QZW7 (Mm), O09028 (Rn) |
CATH/Gene3D | 2.70.170.10 |
ChEMBL Target | CHEMBL2093872 (Hs), CHEMBL2094133 (Mm), CHEMBL1907607 (Rn) |
DrugBank Target | O00591 (Hs), O00591 (Hs) |
Ensembl Gene | ENSG00000094755 (Hs), ENSMUSG00000020159 (Mm), ENSRNOG00000032417 (Rn) |
Entrez Gene | 2568 (Hs), 216643 (Mm), 81658 (Rn) |
Human Protein Atlas | ENSG00000094755 (Hs) |
KEGG Gene | hsa:2568 (Hs), mmu:216643 (Mm), rno:81658 (Rn) |
OMIM | 602729 (Hs) |
Pharos | O00591 (Hs) |
RefSeq Nucleotide | NM_014211 (Hs), NM_146017 (Mm), NM_031029 (Rn) |
RefSeq Protein | NP_055026 (Hs), NP_666129 (Mm), NP_112291 (Rn) |
UniProtKB | O00591 (Hs), Q8QZW7 (Mm), O09028 (Rn) |
Wikipedia | GABRP (Hs) |
Natural/Endogenous Ligands ![]() |
GABA |
Download all structure-activity data for this target as a CSV file
Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution ![]() |
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Gene Expression and Pathophysiology ![]() |
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1. Chen Z, Jin N, Narasaraju T, Chen J, McFarland LR, Scott M, Liu L. (2004) Identification of two novel markers for alveolar epithelial type I and II cells. Biochem Biophys Res Commun, 319 (3): 774-80. [PMID:15184050]
2. Fujii E, Mellon SH. (2001) Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy. Endocrinology, 142 (5): 1770-7. [PMID:11316740]
3. Hedblom E, Kirkness EF. (1997) A novel class of GABAA receptor subunit in tissues of the reproductive system. J Biol Chem, 272 (24): 15346-50. [PMID:9182563]
4. Hood HM, Metten P, Crabbe JC, Buck KJ. (2006) Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav, 5 (1): 1-10. [PMID:16436183]
5. Johnson SK, Haun RS. (2005) The gamma-aminobutyric acid A receptor pi subunit is overexpressed in pancreatic adenocarcinomas. JOP, 6 (2): 136-42. [PMID:15767729]
6. Neelands TR, Zhang J, Macdonald RL. (1999) GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. J Neurosci, 19 (16): 7057-65. [PMID:10436060]