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GABAA receptor ρ2 subunit

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Target not currently curated in GtoImmuPdb

Target id: 421

Nomenclature: GABAA receptor ρ2 subunit

Family: GABAA receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 465 6q15 GABRR2 gamma-aminobutyric acid type A receptor subunit rho2 1
Mouse 4 465 4 A5 Gabrr2 gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 1
Rat 4 465 5q21 Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 2
Previous and Unofficial Names Click here for help
GABA(A) receptor subunit rho-2 | gamma-aminobutyric acid receptor subunit rho-2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | gamma-aminobutyric acid (GABA) C receptor | gamma-aminobutyric acid type A receptor rho 2 subunit | gamma-aminobutyric acid type A receptor rho2 subunit
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GABA

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(±)-cis-2-CAMP Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
[Binds to: GABA site]
5-Me-IAA Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
[Binds to: GABA site]
muscimol Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
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Ligand Sp. Action Value Parameter Reference
cis-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
trans-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
TPMPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent

References

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1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. (1992) Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics, 12 (4): 801-6. [PMID:1315307]

2. Ogurusu T, Taira H, Shingai R. (1995) Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. J Neurochem, 65 (3): 964-8. [PMID:7643126]

Contributors

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