Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	490	6q13-q16.3	GABRR2	gamma-aminobutyric acid type A receptor rho2 subunit	1
Mouse	4	490	4 A5	Gabrr2	gamma-aminobutyric acid (GABA) C receptor, subunit rho 2	1
Rat	4	465	5q21	Gabrr2	gamma-aminobutyric acid type A receptor rho 2 subunit	2

Previous and Unofficial Names

GABA(A) receptor subunit rho-2 | gamma-aminobutyric acid receptor subunit rho-2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | gamma-aminobutyric acid (GABA) C receptor

Database Links
CATH/Gene3D	2.70.170.10
ChEMBL Target	CHEMBL2375 (Hs)
DrugBank Target	P28476 (Hs)
Ensembl Gene	ENSG00000111886 (Hs), ENSMUSG00000023267 (Mm), ENSRNOG00000007490 (Rn)
Entrez Gene	2570 (Hs), 14409 (Mm), 29695 (Rn)
Human Protein Atlas	ENSG00000111886 (Hs)
KEGG Gene	hsa:2570 (Hs), mmu:14409 (Mm), rno:29695 (Rn)
OMIM	137162 (Hs)
RefSeq Nucleotide	NM_002043 (Hs), NM_008076 (Mm), NM_017292 (Rn)
RefSeq Protein	NP_002034 (Hs), NP_032102 (Mm), NP_058988 (Rn)
UniProtKB	P28476 (Hs), P56476 (Mm), P47742 (Rn)
Wikipedia	GABRR2 (Hs)

Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference (±)-cis-2-CAMP Hs Full agonist - - ⤷ [Binds to: GABA site] 5-Me-IAA Hs Full agonist - - ⤷ [Binds to: GABA site] isoguvacine Hs Partial agonist - - ⤷ [Binds to: GABA site] muscimol Hs Partial agonist - - ⤷ [Binds to: GABA site]

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference cis-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] trans-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] aza-THIP Hs Antagonist - - ⤷ [Binds to: GABA site] isonipecotic acid Hs Antagonist - - ⤷ [Binds to: GABA site] piperidine-4-sulphonic acid Hs Antagonist - - ⤷ [Binds to: GABA site] gaboxadol Hs Antagonist - - ⤷ [Binds to: GABA site] TPMPA Hs Antagonist - - ⤷ [Binds to: GABA site]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference picrotoxin Hs - no - - - no ⤷ Not voltage dependent TBPS Hs - no - - - no ⤷ Not voltage dependent