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GABAA receptor ρ2 subunit

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Target not currently curated in GtoImmuPdb

Target id: 421

Nomenclature: GABAA receptor ρ2 subunit

Family: GABAA receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 465 6q15 GABRR2 gamma-aminobutyric acid type A receptor subunit rho2 1
Mouse 4 465 4 A5 Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 1
Rat 4 465 5q21 Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 3
Previous and Unofficial Names Click here for help
GABA(A) receptor subunit rho-2 | gamma-aminobutyric acid receptor subunit rho-2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | gamma-aminobutyric acid (GABA) C receptor | gamma-aminobutyric acid type A receptor rho 2 subunit | gamma-aminobutyric acid type A receptor rho2 subunit
Database Links Click here for help
Alphafold P28476 (Hs), P56476 (Mm), P47742 (Rn)
CATH/Gene3D 2.70.170.10
ChEMBL Target CHEMBL2375 (Hs)
DrugBank Target P28476 (Hs)
Ensembl Gene ENSG00000111886 (Hs), ENSMUSG00000023267 (Mm), ENSRNOG00000007490 (Rn)
Entrez Gene 2570 (Hs), 14409 (Mm), 29695 (Rn)
Human Protein Atlas ENSG00000111886 (Hs)
KEGG Gene hsa:2570 (Hs), mmu:14409 (Mm), rno:29695 (Rn)
OMIM 137162 (Hs)
Pharos P28476 (Hs)
RefSeq Nucleotide NM_002043 (Hs), NM_008076 (Mm), NM_017292 (Rn)
RefSeq Protein NP_002034 (Hs), NP_032102 (Mm), NP_058988 (Rn)
UniProtKB P28476 (Hs), P56476 (Mm), P47742 (Rn)
Wikipedia GABRR2 (Hs)
Natural/Endogenous Ligands Click here for help
GABA

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(±)-cis-2-CAMP Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷ [Binds to: GABA site]
5-Me-IAA Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷ [Binds to: GABA site]
isoguvacine Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
⤷ [Binds to: GABA site]
muscimol Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
⤷ [Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cis-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
trans-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
aza-THIP Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
isonipecotic acid Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
⤷ [Binds to: GABA site]
piperidine-4-sulphonic acid Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
gaboxadol Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - - 2
⤷ [Binds to: GABA site] [2]
TPMPA Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
⤷ [Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent

References

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1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. (1992) Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics, 12 (4): 801-6. [PMID:1315307]

2. Krehan D, Frølund B, Ebert B, Nielsen B, Krogsgaard-Larsen P, Johnston GA, Chebib M. (2003) Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem, 11 (23): 4891-6. [PMID:14604650]

3. Ogurusu T, Taira H, Shingai R. (1995) Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. J Neurochem, 65 (3): 964-8. [PMID:7643126]

Contributors

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