Top ▲
Gene and Protein Information  |
|||||||
| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 1503 | 21q22.3 | TRPM2 | transient receptor potential cation channel subfamily M member 2 | 35,44,47,51,60 |
| Mouse | 6 | 1 | 1506 | 10 39.72 cM | Trpm2 | transient receptor potential cation channel, subfamily M, member 2 | 15 |
| Rat | 6 | 1 | 1508 | 20p12 | Trpm2 | transient receptor potential cation channel, subfamily M, member 2 | 23 |
| Previous and Unofficial Names |
| EREG1 | KNP3 | LTRPC2 | TRPC7 | transient receptor potential melastatin family 2 | transient receptor potential cation channel |
| Database Links |
|
| Alphafold | O94759 (Hs), Q91YD4 (Mm) |
| ChEMBL Target | CHEMBL1250402 (Hs) |
| Ensembl Gene | ENSG00000142185 (Hs), ENSMUSG00000009292 (Mm), ENSRNOG00000001216 (Rn) |
| Entrez Gene | 7226 (Hs), 28240 (Mm), 294329 (Rn) |
| Human Protein Atlas | ENSG00000142185 (Hs) |
| KEGG Gene | hsa:7226 (Hs), mmu:28240 (Mm), rno:294329 (Rn) |
| OMIM | 603749 (Hs) |
| Pharos | O94759 (Hs) |
| RefSeq Nucleotide | NM_003307 (Hs), NM_138301 (Mm), NM_001011559 (Rn) |
| RefSeq Protein | NP_003298 (Hs), NP_612174 (Mm), NP_001011559 (Rn) |
| UniProtKB | O94759 (Hs), Q91YD4 (Mm) |
| Wikipedia | TRPM2 (Hs) |
| Selected 3D Structures |
|||||||||||
|
|
||||||||||
|
|
||||||||||
| Associated Proteins |
||||||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||||
| Functional Characteristics |
|
| γ = 52-60 pS at negative potentials, 76 pS at positive potentials; conducts mono- and di-valent cations non-selectively (PCa/PNa = 0.6-0.7); non-rectifying; inactivation at negative potentials; activated by oxidative stress probably via PARP-1, PARP inhibitors reduce activation by oxidative stress, activation inhibited by suppression of APDR formation by glycohydrolase inhibitors. | |
| Ion Selectivity and Conductance |
||||||
|
||||||
| Ion Selectivity and Conductance Comments | ||||||
| Ranking shown is for 20°C. At >35°C, PCa:PNa ≈ 6. |
| Voltage Dependence Comments |
| Voltage independent. |
| Chemical activators (Human) |
| Agents producing reactive oxygen (e.g. H2O2) and nitrogen (e.g. GEA 3162) species |
| Physical activators (Human) |
| Heat ~ 35°C |
Download all structure-activity data for this target as a CSV file 
| Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Activator Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Activation of TRPM2 is regulated by [Ca2+]i. Elevated Ca2+ levels, probably via calmodulin, sensitise TRPM2 to activation by ADPR [40,57]. Heat potentiates TRPM2 activation [55]. ADP ribose, NAD, NAADP, and OAADPR might directly bind and activate TRPM2, while H2O2 and cADPR indirectly activate TRPM2 through ADP ribose [58]. Activation by oxidative stress is probably mediated by PARP-1. PARP inhibitors (SB750139>PJ34>DPQ) decrease oxidative stress-mediated activation of TRPM2 [10,68]. Catalase [20], dimethylthiourea [53] and mannitol [64] all inhibit oxidative stress-mediated TRPM2 activation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gating Inhibitor Comments | ||
| Glycohydrase inhibitors inhibit endogenous ADPR formation and reduce TRPM2 activation [13]. Short splice variant TRPM2-S (846 aa) inhibits activation of the long splice variant [73]. TRPM2 is inhibited by AMP (IC50=70µM), which competes with ADP ribose for Nudix domain [31,58]. Extracellular or intracellular acidosis inhibits TRPM2; the mechanism is that the extracellular protons compete with Na+ and Ca2+ for channel permeation while intracellular protons antagonize intracellular Ca2+ binding [9,54,70]. Zinc also inactivates TRPM2 and residues in the outer pore (Lys952 and Asp1002) are critical determinants of the inactivation [69]. The GY motif in the TRPM2 selective filter is essential for channel inactivation [59]. |
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blocker Comments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cysteine pore residues (Cys996, Cys1008) are essential for pore functions, mutations of these residues lead to dysfunctional channels [42]. Exceptionally amongst TRP channels, there is no pore block by lanthanides and heavy metal ions [33]. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| Expressed on human T cells, mouse dendritic cells, human and mouse neutrophils and monocytes/macrophages, and mouse mast cells [46]. |
| Cell Type Associations | ||||||||
|
||||||||
|
| Immuno Process Associations | ||
|
||
|
||
|
||
|
| Tissue Distribution
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
| Functional Assays
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
||||||||||
|
| Physiological Functions
|
||||||||
|
||||||||
|
||||||||
|
||||||||
| Physiological Functions Comments | ||||||||
| Activation of TRPM2 causes predisposition to apoptosis and cell death, inhibition of TRPM2 is neuroprotective [1,13,41,74]. | ||||||||
| Phenotypes, Alleles and Disease Models
|
Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||
| Clinically-Relevant Mutations and Pathophysiology
|
||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||
| Gene Expression and Pathophysiology
|
||||||||||||
|
1. Aarts MM, Tymianski M. (2005) TRPMs and neuronal cell death. Pflugers Arch, 451 (1): 243-9. [PMID:16044308]
2. Bari MR, Akbar S, Eweida M, Kühn FJ, Gustafsson AJ, Lückhoff A, Islam MS. (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med, 13 (9B): 3260-7. [PMID:19382906]
3. Beck A, Kolisek M, Bagley LA, Fleig A, Penner R. (2006) Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J, 20 (7): 962-4. [PMID:16585058]
4. Belrose JC, Xie YF, Gierszewski LJ, MacDonald JF, Jackson MF. (2012) Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain, 5: 11. [PMID:22487454]
5. Chubanov V, Gudermann T, Schlingmann KP. (2005) Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch, 451 (1): 228-34. [PMID:16075242]
6. Chung KK, Freestone PS, Lipski J. (2011) Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol, 106 (6): 2865-75. [PMID:21900507]
7. Cruz-Torres I, Backos DS, Herson PS. (2020) Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX. Mol Pharmacol, 97 (2): 102-111. [PMID:31772034]
8. Di A, Gao XP, Qian F, Kawamura T, Han J, Hecquet C, Ye RD, Vogel SM, Malik AB. (2012) The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol, 13 (1): 29-34. [PMID:22101731]
9. Du J, Xie J, Yue L. (2009) Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J Gen Physiol, 134 (6): 471-88. [PMID:19917732]
10. Fonfria E, Marshall IC, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, McNulty S. (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol, 143 (1): 186-92. [PMID:15302683]
11. Fonfria E, Marshall IC, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD, McNulty S. (2005) Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem, 95 (3): 715-23. [PMID:16104849]
12. Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR et al.. (2006) TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26 (3): 179-98. [PMID:16777714]
13. Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krüger S, Weber K, Heiner I, Oppenheimer N et al.. (2006) Activation of T cell calcium influx by the second messenger ADP-ribose. J Biol Chem, 281 (5): 2489-96. [PMID:16316998]
14. Grubisha O, Rafty LA, Takanishi CL, Xu X, Tong L, Perraud AL, Scharenberg AM, Denu JM. (2006) Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem, 281 (20): 14057-65. [PMID:16565078]
15. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J et al.. (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell, 9 (1): 163-73. [PMID:11804595]
16. Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S. (2012) TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci, 32 (11): 3931-41. [PMID:22423113]
17. Heiner I, Eisfeld J, Halaszovich CR, Wehage E, Jüngling E, Zitt C, Lückhoff A. (2003) Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. Biochem J, 371 (Pt 3): 1045-53. [PMID:12564954]
18. Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL. (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci USA, 105 (46): 18029-34. [PMID:19004782]
19. Hermosura MC, Garruto RM. (2007) TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?. Biochim Biophys Acta, 1772 (8): 822-35. [PMID:17395433]
20. Herson PS, Dulock KA, Ashford ML. (1997) Characterization of a nicotinamide-adenine dinucleotide-dependent cation channel in the CRI-G1 rat insulinoma cell line. J Physiol (Lond.), 505 ( Pt 1): 65-76. [PMID:9409472]
21. Hill K, Benham CD, McNulty S, Randall AD. (2004) Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology, 47 (3): 450-60. [PMID:15275834]
22. Hill K, McNulty S, Randall AD. (2004) Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol, 370 (4): 227-37. [PMID:15549272]
23. Hill K, Tigue NJ, Kelsell RE, Benham CD, McNulty S, Schaefer M, Randall AD. (2006) Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology, 50 (1): 89-97. [PMID:16260005]
24. Hiroi T, Wajima T, Negoro T, Ishii M, Nakano Y, Kiuchi Y, Mori Y, Shimizu S. (2013) Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. Cardiovasc Res, 97 (2): 271-81. [PMID:23129587]
25. Hurne AM, Chai CL, Moerman K, Waring P. (2002) Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins. J Biol Chem, 277 (35): 31631-8. [PMID:12063251]
26. Inada H, Iida T, Tominaga M. (2006) Different expression patterns of TRP genes in murine B and T lymphocytes. Biochem Biophys Res Commun, 350 (3): 762-7. [PMID:17027915]
27. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume T, Katsuki H, Mori Y et al.. (2006) A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci, 101 (1): 66-76. [PMID:16651700]
28. Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, Mori Y, Tominaga M. (2012) Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc Natl Acad Sci USA, 109 (17): 6745-50. [PMID:22493272]
29. Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K et al.. (2012) The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death. Cell Calcium, 51 (2): 179-85. [PMID:22226147]
30. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ et al.. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell, 44 (2): 325-40. [PMID:21906983]
31. Kolisek M, Beck A, Fleig A, Penner R. (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell, 18 (1): 61-9. [PMID:15808509]
32. Kraft R, Grimm C, Frenzel H, Harteneck C. (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol, 148 (3): 264-73. [PMID:16604090]
33. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C. (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol, Cell Physiol, 286 (1): C129-37. [PMID:14512294]
34. Kraft R, Harteneck C. (2005) The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflugers Arch, 451 (1): 204-11. [PMID:15895246]
35. Kudoh J, Nagamine K, Asakawa S, Abe I, Kawasaki K, Maeda H, Tsujimoto S, Minoshima S, Ito F, Shimizu N. (1997) Localization of 16 exons to a 450-kb region involved in the autoimmune polyglandular disease type I (APECED) on human chromosome 21q22.3. DNA Res, 4 (1): 45-52. [PMID:9179495]
36. Kühn FJ, Heiner I, Lückhoff A. (2005) TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose. Pflugers Arch, 451 (1): 212-9. [PMID:15952035]
37. Lange I, Penner R, Fleig A, Beck A. (2008) Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils. Cell Calcium, 44 (6): 604-15. [PMID:18572241]
38. Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R. (2009) TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal, 2 (71): ra23. [PMID:19454650]
39. Magnone M, Bauer I, Poggi A, Mannino E, Sturla L, Brini M, Zocchi E, De Flora A, Nencioni A, Bruzzone S. (2012) NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J Biol Chem, 287 (25): 21067-81. [PMID:22547068]
40. McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ. (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem, 278 (13): 11002-6. [PMID:12529379]
41. McNulty S, Fonfria E. (2005) The role of TRPM channels in cell death. Pflugers Arch, 451 (1): 235-42. [PMID:16025303]
42. Mei ZZ, Mao HJ, Jiang LH. (2006) Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Am J Physiol, Cell Physiol, 291 (5): C1022-8. [PMID:16822940]
43. Melzer N, Hicking G, Göbel K, Wiendl H. (2012) TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PLoS ONE, 7 (10): e47617. [PMID:23077651]
44. Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, Shimizu N. (1998) Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics, 54 (1): 124-31. [PMID:9806837]
45. Olah ME, Jackson MF, Li H, Perez Y, Sun HS, Kiyonaka S, Mori Y, Tymianski M, MacDonald JF. (2009) Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (Lond.), 587 (Pt 5): 965-79. [PMID:19124544]
46. Parenti A, De Logu F, Geppetti P, Benemei S. (2016) What is the evidence for the role of TRP channels in inflammatory and immune cells?. Br J Pharmacol, 173 (6): 953-69. [PMID:26603538]
47. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM. (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature, 411 (6837): 595-9. [PMID:11385575]
48. Perraud AL, Schmitz C, Scharenberg AM. (2003) TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium, 33 (5-6): 519-31. [PMID:12765697]
49. Reid G. (2005) ThermoTRP channels and cold sensing: what are they really up to?. Pflugers Arch, 451 (1): 250-63. [PMID:16075243]
50. Roedding AS, Gao AF, Au-Yeung W, Scarcelli T, Li PP, Warsh JJ. (2012) Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar disorder. Bipolar Disord, 14 (2): 151-61. [PMID:22420591]
51. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, Furuichi K. (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science, 293 (5533): 1327-30. [PMID:11509734]
52. Scharenberg AM. (2005) TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors. Pflugers Arch, 451 (1): 220-7. [PMID:16001276]
53. Smith MA, Herson PS, Lee K, Pinnock RD, Ashford ML. (2003) Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel. J Physiol (Lond.), 547 (Pt 2): 417-25. [PMID:12562896]
54. Starkus JG, Fleig A, Penner R. (2010) The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification. J Physiol (Lond.), 588 (Pt 8): 1227-40. [PMID:20194125]
55. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M. (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J, 25 (9): 1804-15. [PMID:16601673]
56. Togashi K, Inada H, Tominaga M. (2008) Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol, 153 (6): 1324-30. [PMID:18204483]
57. Tong Q, Zhang W, Conrad K, Mostoller K, Cheung JY, Peterson BZ, Miller BA. (2006) Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin. J Biol Chem, 281 (14): 9076-85. [PMID:16461353]
58. Tóth B, Csanády L. (2010) Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel. J Biol Chem, 285 (39): 30091-102. [PMID:20650899]
59. Tóth B, Csanády L. (2012) Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci USA, 109 (33): 13440-5. [PMID:22847436]
60. Uemura T, Kudoh J, Noda S, Kanba S, Shimizu N. (2005) Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun, 328 (4): 1232-43. [PMID:15708008]
61. Vaeth M, Feske S. (2018) Ion channelopathies of the immune system. Curr Opin Immunol, 52: 39-50. [PMID:29635109]
62. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. (2011) A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics, 10 (10): M111.013284. [PMID:21890473]
63. Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H. (2018) Structures and gating mechanism of human TRPM2. Science, 362 (6421). [PMID:30467180]
64. Wehage E, Eisfeld J, Heiner I, Jüngling E, Zitt C, Lückhoff A. (2002) Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem, 277 (26): 23150-6. [PMID:11960981]
65. Wehrhahn J, Kraft R, Harteneck C, Hauschildt S. (2010) Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes. J Immunol, 184 (5): 2386-93. [PMID:20107186]
66. Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, Parikh SV, McIntyre RS, Kennedy JL, Warsh JJ. (2006) Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet, 141B (1): 36-43. [PMID:16252251]
67. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T et al.. (2008) TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med, 14 (7): 738-47. [PMID:18542050]
68. Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ, Wu ML. (2006) Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ, 13 (10): 1815-26. [PMID:16294211]
69. Yang W, Manna PT, Zou J, Luo J, Beech DJ, Sivaprasadarao A, Jiang LH. (2011) Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. J Biol Chem, 286 (27): 23789-98. [PMID:21602277]
70. Yang W, Zou J, Xia R, Vaal ML, Seymour VA, Luo J, Beech DJ, Jiang LH. (2010) State-dependent inhibition of TRPM2 channel by acidic pH. J Biol Chem, 285 (40): 30411-8. [PMID:20660597]
71. Yao X, Garland CJ. (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res, 97 (9): 853-63. [PMID:16254217]
72. Yoon IS, Li PP, Siu KP, Kennedy JL, Macciardi F, Cooke RG, Parikh SV, Warsh JJ. (2001) Altered TRPC7 gene expression in bipolar-I disorder. Biol Psychiatry, 50 (8): 620-6. [PMID:11690598]
73. Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA. (2003) A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem, 278 (18): 16222-9. [PMID:12594222]
74. Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY et al.. (2006) TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol, Cell Physiol, 290 (4): C1146-59. [PMID:16306129]
target has curated data in GtoImmuPdb
