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K2P16.1

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Target not currently curated in GtoImmuPdb

Target id: 525

Nomenclature: K2P16.1

Abbreviated Name: TALK1

Family: Two P domain potassium channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 309 6p21.2 KCNK16 potassium two pore domain channel subfamily K member 16 1
Mouse 4 2 292 14 B Kcnk16 potassium channel, subfamily K, member 16
Rat - 2 - 15p16 Kcnk16 potassium two pore domain channel subfamily K member 16
Previous and Unofficial Names Click here for help
TALK1 | potassium channel, two pore domain subfamily K, member 16 | potassium channel
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics Click here for help
Background current

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
isoflurane Small molecule or natural product Approved drug Click here for species-specific activity table Hs - - - 7x10-4 - 9x10-4 - 1
Conc range: 7x10-4 - 9x10-4 M [1]
NO Approved drug Click here for species-specific activity table Hs - - - - - 1
[1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
Ba2+ Click here for species-specific activity table Hs - - - 1x10-3 - 1
Conc range: 1x10-3 M [1]
chloroform Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs - - - 7x10-4 - 8x10-4 - 1
Conc range: 7x10-4 - 8x10-4 M [1]
quinidine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs - - - 1x10-4 - 1
Conc range: 1x10-4 M [1]
Tissue Distribution Click here for help
Placenta.
Species:  Human
Technique:  Northern Blot, cDNA cloning
References:  1-2
Biologically Significant Variant Comments
Alternatively spliced products have been reported but their pharmacological and physiological significance has not been ascertained.
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of both K2P16 and 17 increases with external pH. At present it is unclear if this represents proton block at physiological levels or activation of the channel by supra-physiological alkaline pHo. There are four splice variants of K2P16, two of which are functional [2].

References

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1. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem. Biophys. Res. Commun., 282 (1): 249-56. [PMID:11263999]

2. Han J, Kang D, Kim D. (2003) Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Am. J. Physiol., Cell Physiol., 285 (3): C529-38. [PMID:12724142]

Contributors

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