Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	1	519	16q24.1	KCNG4	potassium voltage-gated channel modifier subfamily G member 4
Mouse	6	1	506	8 E1	Kcng4	potassium voltage-gated channel, subfamily G, member 4
Rat	6	1	506	19q12	Kcng4	potassium voltage-gated channel modifier subfamily G member 4

Previous and Unofficial Names

KV6.3 | potassium channel, voltage gated modifier subfamily G, member 4 | potassium voltage-gated channel

Database Links
Alphafold	Q8TDN1 (Hs), Q80XM3 (Mm)
Ensembl Gene	ENSG00000168418 (Hs), ENSMUSG00000045246 (Mm), ENSRNOG00000015746 (Rn)
Entrez Gene	93107 (Hs), 66733 (Mm), 307900 (Rn)
Human Protein Atlas	ENSG00000168418 (Hs)
KEGG Gene	hsa:93107 (Hs), mmu:66733 (Mm), rno:307900 (Rn)
OMIM	607603 (Hs)
Pharos	Q8TDN1 (Hs)
RefSeq Nucleotide	NM_172347 (Hs), NM_025734 (Mm), NM_001107435 (Rn)
RefSeq Protein	NP_758857 (Hs), NP_080010 (Mm), NP_001100905 (Rn)
UniProtKB	Q8TDN1 (Hs), Q80XM3 (Mm)
Wikipedia	KCNG4 (Hs)

Ion Selectivity and Conductance
Species:  None Macroscopic current rectification:  Modifiers/ Silencer References:

Tissue Distribution
Brain, liver, small intestine, colon Species:  Human Technique:  RT-PCR References:  4

Functional Assays
Molecular clone, patch clamp, yeast two-hybrid and co-immunoprecipitation Species:  Human Tissue:  Ltk- cells (murine fibroblast cell line) Response measured:  Kv6.4 are "silent" subunits and form heterotetrameric channels with the Kv2 subfamily References:  1,4

Physiological Functions
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents. It modulates the activity of Kv2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation. Species:  Human Tissue:  Ltk- cells References:  4

Biologically Significant Variants
Type:  Splice variant Species:  Human Description:  Kv6.4 has no function on its own, but it has important modulatory actions on Kv2 channels Amino acids:  519 Nucleotide accession:  NM_172347 Protein accession:  NP_758857
Biologically Significant Variant Comments
A total of 731 SNPs have been identified in human KCNG4. For more information, please see the entry on GeneCards. This variant has questionable validity because it originates from a cancer cell line [3] : RNA sequence: NM_133490 Protein sequence: NP_597997 Amino acids: 256 Type: Splice variant Species: Human

General Comments
Kv6.4 has no function on its own, but has important modulatory actions on Kv2 channels. Interaction with Kv2.1 is mediated by interactions between N- and C-termini [2].