Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	1	526	20q13.12	KCNS1	potassium voltage-gated channel modifier subfamily S member 1	3
Mouse	6	1	497	2 H3	Kcns1	K+ voltage-gated channel, subfamily S, 1
Rat	6	1	497	3q42	Kcns1	potassium voltage-gated channel, modifier subfamily S, member 1

Previous and Unofficial Names

delayed-rectifier K(+) channel alpha subunit 1 | potassium voltage-gated channel, modifier subfamily S, member 1 | potassium voltage-gated channel | K+ voltage-gated channel

Database Links
Alphafold	Q96KK3 (Hs), O35173 (Mm), O88758 (Rn)
Ensembl Gene	ENSG00000124134 (Hs), ENSMUSG00000040164 (Mm), ENSRNOG00000013681 (Rn)
Entrez Gene	3787 (Hs), 16538 (Mm), 117023 (Rn)
Human Protein Atlas	ENSG00000124134 (Hs)
KEGG Gene	hsa:3787 (Hs), mmu:16538 (Mm), rno:117023 (Rn)
OMIM	602905 (Hs)
Pharos	Q96KK3 (Hs)
RefSeq Nucleotide	NM_002251 (Hs), NM_008435 (Mm), NM_053954 (Rn)
RefSeq Protein	NP_002242 (Hs), NP_032461 (Mm), NP_446406 (Rn)
UniProtKB	Q96KK3 (Hs), O35173 (Mm), O88758 (Rn)
Wikipedia	KCNS1 (Hs)

Associated Proteins
Heteromeric Pore-forming Subunits Name References Kv2 3	Auxiliary Subunits Name References Not determined	Other Associated Proteins Name References Not determined

Ion Selectivity and Conductance
Species:  None Macroscopic current rectification:  Modifiers/ Silencer References:
Ion Selectivity and Conductance Comments
Electrically silent on its own.

Tissue Distribution
Infant brain, adult brain (frontal cortex), lens epithelium, melanocytes Species:  Human Technique:  RT-PCR References:  3
Main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, cerebellum. Species:  Mouse Technique:  Northern Blot, in situ hybridization References:  2
Brain Species:  Rat Technique:  Northern Blot References:  4
Tissue Distribution Comments
A very similar localization of Kv9 and Kv2 subunits has been observed at the cellular level in granular cells of the olfactory bulb, Purkinje and granular cells of the cerebellum, pyramidal cells of the hippocampus, and in granular cells of the dentate gyrus [2]

Physiological Functions

Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current. Kv9.1 modulates the activity of Kv2.1 and Kv2.2 α subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarised values, and enhances the single-channel conductance of Kv2.1. Species:  Mouse Tissue:  COS m6 cells References:  1-2

General Comments
The human Kv9.1 gene is composed of a minimum of 5 exons, with at least 2 alternatively spliced exons in the 5' - untranslated region [1-4].