Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	1	1107	3p24.3	KCNH8	potassium voltage-gated channel subfamily H member 8
Mouse	6	1	1102	17 C	Kcnh8	potassium voltage-gated channel, subfamily H (eag-related), member 8
Rat	6	1	1102	9q11	Kcnh8	potassium voltage-gated channel subfamily H member 8

Previous and Unofficial Names

elk1 | elk3 | ELK channel 3 | ether-a-go-go-like potassium channel 1 | ether-a-go-go-like potassium channel 3 | Ets-1 | potassium voltage-gated channel, subfamily H (eag-related), member 8 | potassium channel, voltage gated eag related subfamily H, member 8 | potassium voltage-gated channel

Database Links
Alphafold	Q96L42 (Hs), P59111 (Mm), Q9QWS8 (Rn)
CATH/Gene3D	2.60.120.10
Ensembl Gene	ENSG00000183960 (Hs), ENSMUSG00000035580 (Mm), ENSRNOG00000058626 (Rn)
Entrez Gene	131096 (Hs), 211468 (Mm), 246325 (Rn)
Human Protein Atlas	ENSG00000183960 (Hs)
KEGG Gene	hsa:131096 (Hs), mmu:211468 (Mm), rno:246325 (Rn)
OMIM	608260 (Hs)
Pharos	Q96L42 (Hs)
RefSeq Nucleotide	NM_144633 (Hs), NM_001031811 (Mm), NM_145095 (Rn)
RefSeq Protein	NP_653234 (Hs), NP_001026981 (Mm), NP_659563 (Rn)
UniProtKB	Q96L42 (Hs), P59111 (Mm), Q9QWS8 (Rn)
Wikipedia	KCNH8 (Hs)

Ion Selectivity and Conductance
Species:  Human Macroscopic current rectification:  Ik References:  5

Voltage Dependence
V0.5 (mV)  τ (msec)  Reference  Cell type  Species  Activation  -62.0 259.0 – 45.0 5 Xenopus laevis Oocytes Human Inactivation  - - Deactivation  - 331.0 – 66.0 5
V0.5 (mV)  τ (msec)  Reference  Cell type  Species  Activation  9.0 - 2 Xenopus laevis Oocytes Rat Inactivation  - - Comments  Voltage sensitivity is sensitive to internal pH: V0.5=10mV at pH 7.7 V0.5=28mV at pH 6.6 [2]

Associated subunits (Human)

minK (KCNE1)

Download all structure-activity data for this target as a CSV file

Gating inhibitors
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference Zn2+ Mm - - - - - 4 ⤷ [4] Description: 1 mM Zn2+ slows activation 10-fold and shifts V0.5 for activation by ~+47 mV Conditions: Heterologous expression in Xenopus oocytes Cd2+ Mm - - - - - 4 ⤷ [4] Description: 1 mM Cd2+ slows activation 5-fold and shifts V0.5 for activation by +35 mV Conditions: Heterologous expression in Xenopus oocytes

Channel Blockers
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference Ba2+ Hs - 3.7 pIC50 - - 5 ⤷ pIC50 3.7 [5]

Tissue Distribution
Primarily expressed in nervous system, especially prominent in the forebrain, cerebral cortex, hippocampus, amygdala, caudate, and nucleus accumbens. KCNH8 and KCNH3 genes also expressed together in the thalamus, substantia nigra, pons, and cerebellum; however the balance of expression level is shifted toward KCNH8. Expression very low in nonneuronal tissues. Species:  Human Technique:  RT-PCR References:  5
Caudate / putamen, accumbens nuclei > cerebral cortex Species:  Rat Technique:  In situ hybridisation References:  1

Functional Assays
Voltage clamp of heterologously expressed Kv12.1 currents Species:  Human Tissue:  Xenopus laevis oocytes Response measured:  K+-selective channel, co-assembly with Kv12.2 and Kv12.3 References:  5
Voltage clamp of heterologously expressed Kv12.1 currents Species:  Rat Tissue:  Xenopus laevis oocytes Response measured:  Slowly activating outward rectifier References:  2

Physiological Consequences of Altering Gene Expression
β-catenin regulates gene expression Species:  Rat Tissue:  Thalamic neurons Technique:  References:  3

General Comments
This channel has: GFG (rather than the common GYG) potassium channel signature sequence a PAS domain in the distal part of the cytosolic N-terminus a cNBD domain in the proximal portion of the C-terminus