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Retinoic acid receptor-β

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Target not currently curated in GtoImmuPdb

Target id: 591

Nomenclature: Retinoic acid receptor-β

Systematic Nomenclature: NR1B2

Family: 1B. Retinoic acid receptors

Gene and Protein Information Click here for help
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 455 3p24.2 RARB retinoic acid receptor beta 3,32
Mouse 482 14 7.08 cM Rarb retinoic acid receptor, beta 32,34,53-54
Rat 291 15p16 Rarb retinoic acid receptor, beta 32
Gene and Protein Information Comments
The 448 aa human isoform (1, a.k.a. β2) is the predominant transcript. Other alternatively spliced transcripts are described, including the 455 aa isoform 3 (a.k.a. β1; NP_001277145).
Previous and Unofficial Names Click here for help
HAP | HBV-activated protein | RAR beta 2 | retinoic acid receptor
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  RAR-β (ligand-binding domain)
PDB Id:  1XAP
Ligand:  TTNPB
Resolution:  2.1Å
Species:  Human
References:  13
Natural/Endogenous Ligands Click here for help
tretinoin

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists Click here for help
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]9-cis-retinoic acid Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Mm Full agonist 9.4 pKd 1
pKd 9.4 (Kd 4x10-10 M) [1]
CD666 Small molecule or natural product Click here for species-specific activity table Hs Agonist 5.6 pKd 2
pKd 5.6 [2]
alitretinoin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 9.7 pKi 19,35
pKi 9.7 [19,35]
tretinoin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Agonist 9.4 pKi 18-19,35,43
pKi 9.4 [18-19,35,43]
adapalene Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Agonist 7.5 pKi 5
pKi 7.5 (Ki 3.4x10-8 M) [5]
Description: Binding affinity to RARβ using [3H]CD 367 as radioligand.
tazarotene Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Agonist 9.1 pEC50 6
pEC50 9.1 (EC50 8x10-10 M) [6]
KCL-286 Small molecule or natural product Hs Agonist 8.7 pEC50 15
pEC50 8.7 (EC50 1.9x10-9 M) [15]
Ro 40-6055 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 8.1 pEC50 6
pEC50 8.1 (EC50 8.6x10-9 M) [6]
AC261066 Small molecule or natural product Hs Full agonist 7.9 – 8.1 pEC50 29
pEC50 7.9 – 8.1 [29]
tretinoin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 7.9 pEC50 6
pEC50 7.9 (EC50 1.2x10-8 M) [6]
AC55649 Small molecule or natural product Hs Full agonist 6.9 – 7.3 pEC50 28-29
pEC50 6.9 – 7.3 [28-29]
Description: Affinity for RARβ2 isoform.
trifarotene Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Agonist 6.9 pEC50 44
pEC50 6.9 (EC50 1.25x10-7 M) [44]
Description: In a reported assay measuring activation mediated by agonist binding to the RARβ ligand-binding domain.
tamibarotene Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 6.6 pEC50 45
pEC50 6.6 (EC50 2.35x10-7 M) [45]
BMS641 Small molecule or natural product Ligand has a PDB structure Hs Agonist 8.6 pIC50 13
pIC50 8.6 [13]
TTNPB Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 8.0 pIC50 18-19,35,43
pIC50 8.0 [18-19,35,43]
View species-specific agonist tables
Agonist Comments
All-trans-retinoic acid is the most potent endogenous retinoid. The existence of 9-cis retinoic acid as a natural bioactive retinoid remains to be established. Synthetic compounds (reported above) are not metabolized by CYP26. BMS641 is a partial RARβ-selective agonist. However no fully RARβ-selective agonist has been reported so far.
Although tazarotene has high affinity for all retinoic acid receptor isoforms, it has roughly 5-8 times higher affinity for the β isoform [6].
Adapalene is selective for the β and γ RARs over the α isoform [5].
Antagonists Click here for help
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AGN193109 Small molecule or natural product Click here for species-specific activity table Hs Inverse agonist 8.7 pIC50 20-21,43
pIC50 8.7 [20-21,43]
BMS493 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inverse agonist 8.5 pIC50 12
pIC50 8.5 [12]
Antagonist Comments
To date, no pure RARβ-selective antagonist has been reported. Both AGN193109 and BMS493 inverse agonists can induce corepressor association with RARβ instead of RARα.
DNA Binding Click here for help
Structure:  Heterodimer, RXR partner
HRE core sequence:  5’-PuG(G/T)TCA
Response element:  DR5
DNA Binding Comments
Transient transfection using a reporter gene and EMSA have shown that RXR-RARβ heterodimers bind to a DR5 element.
Co-binding Partners Click here for help
Name Interaction Effect Reference
AP1 Functional RARb inhibits AP-1 driven transactivation 36
Main Co-regulators Click here for help
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes A member of the p160 family 11,37
MED1 Co-activator No Yes Yes A member of the DRIP/TRAP/SMCC complex 25,33,39,52
NCOA3 Co-activator No Yes Yes A member of the p160 family 7,11,26
NCOA2 Co-activator No Yes Yes A member of the p160 family 12,24,46
Tissue Distribution Click here for help
Brain, liver, kidney, heart, pituitary, colon, uterus, ovary, testis, prostate, adrenal, eye.
Expression level:  High
Species:  Human
Technique:  in situ hybridisation, Northern blot, Western blotting
References:  8-10,17,23,41-42
Tissue Distribution Comments
Similar distribution patterns are seen in the mouse and rat.
Physiological Consequences of Altering Gene Expression Click here for help
RARβ null mutant : - abnormalities observed: growth retardation; behavorial defects; altered alveolar formation. - congenital defects observed: homeotic transformations and malformations of cervical vertebrae; persistence and hyperplasia of the primary vitreous body.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  14,16,22,30-31
Physiological Consequences of Altering Gene Expression Comments
Note that the specific RARβ1/β3 null mutants are apparently normal, and the specific RARβ2/β4 null mutants exhibited persistence and hyperplasia of the primary vitreous body.
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002191 abnormal artery morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002257 abnormal arytenoid cartilage morphology PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002884 abnormal branchial arch morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001310 abnormal conjunctiva morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010584 abnormal conotruncus septation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005300 abnormal corneal stroma morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002085 abnormal embryonic tissue morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000468 abnormal esophageal epithelium morphology PMID: 7607068 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0002912 abnormal excitatory postsynaptic potential PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0002912 abnormal excitatory postsynaptic potential PMID: 9883728 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005205 abnormal eye anterior chamber PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001286 abnormal eye development PMID: 16207763 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0008380 abnormal gonial bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001076 abnormal hypoglossal nerve morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006063 abnormal inferior vena cava morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005208 abnormal iris stroma morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002265 abnormal left major bronchus morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002840 abnormal lens fiber morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 16207763 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001175 abnormal lung morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008969 abnormal nasolacrimal duct morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0004054 abnormal periocular mesenchyme morphology PMID: 16207763 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0006069 abnormal retinal neuronal layer morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 16207763 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001325 abnormal retina morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002266 abnormal right major bronchus morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002698 abnormal sclera morphology PMID: 9240560 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 7607068 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001463 abnormal spatial learning PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001463 abnormal spatial learning PMID: 9883728 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005107 abnormal stapes morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000471 abnormal stomach epithelium morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003117 abnormal tracheal-esophageal septation PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000534 abnormal ureter morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001139 abnormal vagina morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002699 abnormal vitreous body PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000159 abnormal xiphoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001899 absent long term depression PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001899 absent long term depression PMID: 9883728 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001181 absent lungs PMID: 7607068 
Rarb+|Rarbtm1Mma Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008514 absent retinal inner plexiform layer PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004666 absent stapedial artery PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001304 cataracts PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010714 coloboma of the iris PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010716 coloboma of the optic disc PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001262 decreased body weight PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008972 ethmoturbinate hypoplasia PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003924 herniated diaphragm PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000519 hydronephrosis PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004616 lumbar vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97857  MP:0002169 no abnormal phenotype detected PMID: 7958449 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001289 persistence of hyaloid vascular system PMID: 9240560 
Rarbtm2.1Ipc Rarbtm2.1Ipc/Rarbtm2.1Ipc
involves: C57BL/6 * SJL
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 11857787 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 16207763 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001732 postnatal growth retardation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001473 reduced long term potentiation PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001473 reduced long term potentiation PMID: 9883728 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004158 right aortic arch PMID: 9240560 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009076 rudimentary Mullerian ducts PMID: 7607068 
Rarbtm1Mma|Rargtm4Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97857  MGI:97858  MP:0003604 single kidney PMID: 9376317 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010702 split cervical atlas PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010702 split cervical atlas PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004687 split vertebrae PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010402 ventricular septal defect PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0006200 vitreous body deposition PMID: 9240560 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Breast cancer
Disease Ontology: DOID:1612
OMIM: 114480
Role: 
References:  47-50
Disease:  Esophageal cancer
Disease Ontology: DOID:5041
OMIM: 133239
Role: 
References:  40
Disease:  Lung cancer
Disease Ontology: DOID:1324
OMIM: 211980
Role: 
References:  4,38,51
Disease:  Microphthalmia, syndromic 12; MCOPS12
Synonyms: Matthew-Wood syndrome [Orphanet: ORPHA2470]
OMIM: 615524
Orphanet: ORPHA2470
Biologically Significant Variants Click here for help
Type:  Splice variant
Species:  Human
Description:  RARβ1: retinoic acid receptor, beta isoform 1. The b1 isoform differs from b2 in the A domain.
Amino acids:  448
Protein accession: 
References:  54
Type:  Splice variant
Species:  Human
Description:  RARβ2: retinoic acid receptor, beta isoform 2:- In contrast to the b1 isoform, b2 is transcribed from promoter (the downstream one, P2) that contains a DR5 and which is inducible by retinoid. The b2 isoform differs from b1 in the A domain.
Amino acids:  336
Protein accession: 
References:  54
Type:  Splice variant
Species:  Mouse
Description:  RARβ3:- b3 isoform is generated from the promoter P1 and differs from b1 isoform by its N-terminal part. It was not detected in human.
Amino acids:  448
Protein accession: 
References:  54
Type:  Splice variant
Species:  Human
Description:  RARβ4:- b4 isoform is generated from the promoter P2 and differs from b2 isoform by its N-terminal part that initiate in a non-AUG codon, CUG.
References:  34
General Comments
Using F9 RARβ2 null cells, some genes have been identified that require RARβ2 for their regulation by ATRA in F9 cells [27,55]. In contrast to RARα, unliganded RARβ poorly interacts with both NCoR and SMRT corepressors.

References

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1. Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P. (1993) Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA, 90 (1): 30-4. [PMID:8380496]

2. Bernard BA, Bernardon JM, Delescluse C, Martin B, Lenoir MC, Maignan J, Charpentier B, Pilgrim WR, Reichert U, Shroot B. (1992) Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun, 186 (2): 977-83. [PMID:1323296]

3. Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P, Dejean A. (1988) Identification of a second human retinoic acid receptor. Nature, 332 (6167): 850-3. [PMID:2833708]

4. Castillo L, Milano G, Santini J, Demard F, Pierrefite V. (1997) Analysis of retinoic acid receptor beta expression in normal and malignant laryngeal mucosa by a sensitive and routine applicable reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay method. Clin Cancer Res, 3 (11): 2137-42. [PMID:9815607]

5. Charpentier B, Bernardon JM, Eustache J, Millois C, Martin B, Michel S, Shroot B. (1995) Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem, 38 (26): 4993-5006. [PMID:8544175]

6. Charton J, Deprez-Poulain R, Hennuyer N, Tailleux A, Staels B, Deprez B. (2009) Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorg Med Chem Lett, 19 (2): 489-92. [PMID:19058965]

7. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell, 90 (3): 569-80. [PMID:9267036]

8. de The H, Marchio A, Tiollais P, Dejean A. (1989) Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J, 8 (2): 429-33. [PMID:2542014]

9. Dollé P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P. (1989) Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature, 342 (6250): 702-5. [PMID:2556642]

10. Dollé P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P. (1990) Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development, 110 (4): 1133-51. [PMID:1966045]

11. Farboud B, Hauksdottir H, Wu Y, Privalsky ML. (2003) Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol, 23 (8): 2844-58. [PMID:12665583]

12. Germain P, Iyer J, Zechel C, Gronemeyer H. (2002) Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature, 415 (6868): 187-92. [PMID:11805839]

13. Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H. (2004) Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep, 5 (9): 877-82. [PMID:15319780]

14. Ghyselinck NB, Dupé V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C, Chambon P, Mark M. (1997) Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol, 41 (3): 425-47. [PMID:9240560]

15. Goncalves MB, Clarke E, Jarvis CI, Barret Kalindjian S, Pitcher T, Grist J, Hobbs C, Carlstedt T, Jack J, Brown JT et al.. (2019) Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett, 29 (8): 995-1000. [PMID:30792038]

16. Grondona JM, Kastner P, Gansmuller A, Décimo D, Chambon P, Mark M. (1996) Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Development, 122 (7): 2173-88. [PMID:8681798]

17. Haq R, Pfahl M, Chytil F. (1991) Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc Natl Acad Sci USA, 88 (18): 8272-6. [PMID:1654565]

18. Keidel S, LeMotte P, Apfel C. (1994) Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. Mol Cell Biol, 14 (1): 287-98. [PMID:8264595]

19. Klaholz BP, Mitschler A, Moras D. (2000) Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. J Mol Biol, 302 (1): 155-70. [PMID:10964567]

20. Klein ES, Pino ME, Johnson AT, Davies PJ, Nagpal S, Thacher SM, Krasinski G, Chandraratna RA. (1996) Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem, 271 (37): 22692-6. [PMID:8798442]

21. Klein ES, Wang JW, Khalifa B, Gavigan SA, Chandraratna RA. (2000) Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. J Biol Chem, 275 (25): 19401-8. [PMID:10777502]

22. Krezel W, Ghyselinck N, Samad TA, Dupé V, Kastner P, Borrelli E, Chambon P. (1998) Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science, 279 (5352): 863-7. [PMID:9452386]

23. Krust A, Kastner P, Petkovich M, Zelent A, Chambon P. (1989) A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci USA, 86 (14): 5310-4. [PMID:2546152]

24. Laudet V, Gronemeyer H. (2002) The Nuclear Receptor Facts Book. In The Nuclear Receptor Facts Book. (Academic Press) .

25. Lemon BD, Freedman LP. (1999) Nuclear receptor cofactors as chromatin remodelers. Curr Opin Genet Dev, 9 (5): 499-504. [PMID:10508693]

26. Li H, Gomes PJ, Chen JD. (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci USA, 94 (16): 8479-84. [PMID:9238002]

27. Li R, Faria TN, Boehm M, Nabel EG, Gudas LJ. (2004) Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells. Exp Cell Res, 294 (1): 290-300. [PMID:14980522]

28. Lund BW, Knapp AE, Piu F, Gauthier NK, Begtrup M, Hacksell U, Olsson R. (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands. J Med Chem, 52 (6): 1540-5. [PMID:19239230]

29. Lund BW, Piu F, Gauthier NK, Eeg A, Currier E, Sherbukhin V, Brann MR, Hacksell U, Olsson R. (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem, 48 (24): 7517-9. [PMID:16302793]

30. Mark M, Chambon P. (2003) Functions of RARs and RXRs in vivo: genetic dissection of the retinoid signaling pathway. Pure Appl Chem, 75: 1709-1732.

31. Mark M, Ghyselinck NB, Chambon P. (2006) Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol, 46: 451-80. [PMID:16402912]

32. Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P. (1991) Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. Genomics, 10 (4): 1061-9. [PMID:1655630]

33. McKenna NJ, Lanz RB, O'Malley BW. (1999) Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev, 20 (3): 321-44. [PMID:10368774]

34. Nagpal S, Zelent A, Chambon P. (1992) RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. Proc Natl Acad Sci USA, 89 (7): 2718-22. [PMID:1313565]

35. Nagy L, Thomázy VA, Shipley GL, Fésüs L, Lamph W, Heyman RA, Chandraratna RA, Davies PJ. (1995) Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol, 15 (7): 3540-51. [PMID:7791761]

36. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P. (1990) Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J, 9 (13): 4443-54. [PMID:2176152]

37. Oñate SA, Tsai SY, Tsai MJ, O'Malley BW. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science, 270 (5240): 1354-7. [PMID:7481822]

38. Picard E, Seguin C, Monhoven N, Rochette-Egly C, Siat J, Borrelly J, Martinet Y, Martinet N, Vignaud JM. (1999) Expression of retinoid receptor genes and proteins in non-small-cell lung cancer. J Natl Cancer Inst, 91 (12): 1059-66. [PMID:10379969]

39. Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Pérez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W. (2005) Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J Biol Chem, 280 (2): 1625-33. [PMID:15528208]

40. Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC. (1999) Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis. Am J Pathol, 155 (5): 1519-23. [PMID:10550308]

41. Ruberte E, Dolle P, Chambon P, Morriss-Kay G. (1991) Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development, 111 (1): 45-60. [PMID:1849812]

42. Ruberte E, Dolle P, Krust A, Zelent A, Morriss-Kay G, Chambon P. (1990) Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development, 108 (2): 213-22. [PMID:2161730]

43. Thacher SM, Vasudevan J, Chandraratna RA. (2000) Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des, 6 (1): 25-58. [PMID:10637371]

44. Thoreau E, Arlabosse JM, Bouix-Peter C, Chambon S, Chantalat L, Daver S, Dumais L, Duvert G, Feret A, Ouvry G et al.. (2018) Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. Bioorg Med Chem Lett, 28 (10): 1736-1741. [PMID:29706423]

45. Vizirianakis IS, Chatzopoulou M, Bonovolias ID, Nicolaou I, Demopoulos VJ, Tsiftsoglou AS. (2010) Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. J Med Chem, 53 (19): 6779-810. [PMID:20925433]

46. Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H. (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J, 15 (14): 3667-75. [PMID:8670870]

47. Widschwendter M, Berger J, Daxenbichler G, Müller-Holzner E, Widschwendter A, Mayr A, Marth C, Zeimet AG. (1997) Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer. Cancer Res, 57 (19): 4158-61. [PMID:9331065]

48. Widschwendter M, Berger J, Hermann M, Müller HM, Amberger A, Zeschnigk M, Widschwendter A, Abendstein B, Zeimet AG, Daxenbichler G, Marth C. (2000) Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J Natl Cancer Inst, 92 (10): 826-32. [PMID:10814678]

49. Widschwendter M, Berger J, Müller HM, Zeimet AG, Marth C. (2001) Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer. J Mammary Gland Biol Neoplasia, 6 (2): 193-201. [PMID:11501579]

50. Xu XC, Sneige N, Liu X, Nandagiri R, Lee JJ, Lukmanji F, Hortobagyi G, Lippman SM, Dhingra K, Lotan R. (1997) Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level during breast carcinogenesis. Cancer Res, 57 (22): 4992-6. [PMID:9371489]

51. Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R. (1997) Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. J Natl Cancer Inst, 89 (9): 624-9. [PMID:9150186]

52. Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG. (1998) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci USA, 95 (14): 7939-44. [PMID:9653119]

53. Zelent A, Krust A, Petkovich M, Kastner P, Chambon P. (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature, 339 (6227): 714-7. [PMID:2544807]

54. Zelent A, Mendelsohn C, Kastner P, Krust A, Garnier JM, Ruffenach F, Leroy P, Chambon P. (1991) Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. EMBO J, 10 (1): 71-81. [PMID:1846599]

55. Zhuang Y, Faria TN, Chambon P, Gudas LJ. (2003) Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. Mol Cancer Res, 1 (8): 619-30. [PMID:12805409]

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1B. Retinoic acid receptors: Retinoic acid receptor-β. Last modified on 10/07/2023. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=591.