Gene and Protein Information
Species	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1p13.2	NR1H5P	nuclear receptor subfamily 1 group H member 5, pseudogene
Mouse	505	3 F2.2	Nr1h5	nuclear receptor subfamily 1, group H, member 5	1
Rat	-	2q34	Nr1h5	nuclear receptor subfamily 1, group H, member 5
Gene and Protein Information Comments
FXRb is a pseudogene in human[1]

Previous and Unofficial Names

FXRβ | Lanosterol receptor | Nr1h5p | nuclear receptor subfamily 1, group H, member 5, pseudogene | nuclear receptor subfamily 1

Database Links
Ensembl Gene	ENSG00000227970 (Hs), ENSMUSG00000048938 (Mm), ENSRNOG00000023073 (Rn)
Entrez Gene	643609 (Hs), 381463 (Mm), 690430 (Rn)
Human Protein Atlas	ENSG00000227970 (Hs)
KEGG Gene	hsa:643609 (Hs), mmu:381463 (Mm), rno:690430 (Rn)
OMIM	3026618 (Hs)
RefSeq Nucleotide	NM_201619 (Mm), NM_198658 (Mm), NM_201622 (Mm)
RefSeq Protein	NP_963916 (Mm), NP_963913 (Mm), NP_941060 (Mm)
Wikipedia	NR1H5P (Hs)

Natural/Endogenous Ligands
cholesten
desmosterol
lanosterol
vitamin D3
Comments: A series of oxysterols and bile acids are natural ligands

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference lanosterol Mm Agonist 6.0 pEC50 1 ⤷ pEC50 6.0 [1] vitamin D3 Mm Agonist 5.0 pEC50 1 ⤷ pEC50 5.0 [1] desmosterol Mm Agonist 5.0 pEC50 1 ⤷ pEC50 5.0 [1] cholesten Mm Agonist 5.0 pEC50 1 ⤷ pEC50 5.0 [1]

DNA Binding
Structure:  Heterodimer HRE core sequence:  AGTTCA N TGAACT Response element:
DNA Binding Comments
Also binds as RXR heterodimer to an everted repeat with a spacer of 2 (ER2).

Main Co-regulators
Name	Activity	Specific	Ligand dependent	AF-2 dependent	Comments	References
NCOA1	Co-activator	No	Yes	No		1

Tissue Distribution
Ubiquitous Species:  Mouse Technique:  RT-PCR References:  1

Biologically Significant Variants
Type:  Splice variant Species:  Mouse Description:  nuclear receptor subfamily 1, group H, member 5 isoform 1 Amino acids:  505 Protein accession:  NP_941060 References:  1
Type:  Splice variant Species:  Mouse Description:  nuclear receptor subfamily 1, group H, member 5 isoform 2 Amino acids:  497 Protein accession:  NP_963913 References:  1
Type:  Splice variant Species:  Mouse Description:  nuclear receptor subfamily 1, group H, member 5 isoform 5 Amino acids:  447 Protein accession:  NP_963916 References:  1