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Target not currently curated in GtoImmuPdb
Target id: 646
Nomenclature: isopentenyl-diphosphate Δ-isomerase 1
Family: Lanosterol biosynthesis pathway
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 227 | 10p15.3 | IDI1 | isopentenyl-diphosphate delta isomerase 1 | 3 |
| Mouse | - | 227 | 13 A1 | Idi1 | isopentenyl-diphosphate delta isomerase | |
| Rat | - | 227 | 17q12.1 | Idi1 | isopentenyl-diphosphate delta isomerase 1 | |
| Previous and Unofficial Names |
| IPPI1 | methylbutenylpyrophosphate isomerase | IPP isomerase 1 | isopentenyl pyrophosphate isomerase 1 |
| Database Links |
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| Alphafold | Q13907 (Hs), P58044 (Mm), O35760 (Rn) |
| BRENDA | 5.3.3.2 |
| ChEMBL Target | CHEMBL4523132 (Rn) |
| Ensembl Gene | ENSG00000067064 (Hs), ENSMUSG00000058258 (Mm), ENSRNOG00000016690 (Rn) |
| Entrez Gene | 3422 (Hs), 319554 (Mm), 89784 (Rn) |
| Human Protein Atlas | ENSG00000067064 (Hs) |
| KEGG Enzyme | 5.3.3.2 |
| KEGG Gene | hsa:3422 (Hs), mmu:319554 (Mm), rno:89784 (Rn) |
| OMIM | 604055 (Hs) |
| Pharos | Q13907 (Hs) |
| RefSeq Nucleotide | NM_004508 (Hs), NM_145360 (Mm), NM_053539 (Rn) |
| RefSeq Protein | NP_004499 (Hs), NP_663335 (Mm), NP_445991 (Rn) |
| UniProtKB | Q13907 (Hs), P58044 (Mm), O35760 (Rn) |
| Wikipedia | IDI1 (Hs) |
| Selected 3D Structures |
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| Enzyme Reaction |
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| Substrates and Reaction Kinetics |
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| Cofactors |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution Comments | |
| Ubiquitously expressed [1]. |
1. Breitling R, Laubner D, Clizbe D, Adamski J, Krisans SK. (2003) Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. J Mol Evol, 57 (3): 282-91. [PMID:14629038]
2. Hahn FM, Xuan JW, Chambers AF, Poulter CD. (1996) Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch Biochem Biophys, 332 (1): 30-4. [PMID:8806705]
3. Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F et al.. (2010) Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. Biochem Biophys Res Commun, 402 (2): 438-42. [PMID:20955688]
4. Thompson K, Dunford JE, Ebetino FH, Rogers MJ. (2002) Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun, 290 (2): 869-73. [PMID:11785983]
5. Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J Mol Biol, 366 (5): 1437-46. [PMID:17137593]
6. Zheng W, Sun F, Bartlam M, Li X, Li R, Rao Z. (2007) The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis. J Mol Biol, 366 (5): 1447-58. [PMID:17250851]
