Top ▲

RyR3

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 749

Nomenclature: RyR3

Family: Ryanodine receptors

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 0 4870 15q13.3-q14 RYR3 ryanodine receptor 3
Mouse 6 0 4888 2 E3-E4 Ryr3 ryanodine receptor 3
Rat 3 0 248 3q35 Ryr3 ryanodine receptor 3
Previous and Unofficial Names Click here for help
ryanodine receptor 3 | calcium release channel isoform 3
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Functional Characteristics Click here for help
Ca2+: (P Ca/P K6) single-channel conductance: 140 pS (50mM Ca2+), 777 pS (250 mM K+)

Download all structure-activity data for this target as a CSV file go icon to follow link

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
caffeine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs - - - - -
pharmacological; mM range
cytosolic Ca2+ Click here for species-specific activity table Ligand is endogenous in the given species Hs - - - - -
endogenous; μM range
cytosolic ATP Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs - - - - -
endogenous; mM range
ryanodine Small molecule or natural product Click here for species-specific activity table Hs - - - - -
pharmacological; nM - μM range
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cytosolic Ca2+ Click here for species-specific activity table Ligand is endogenous in the given species Hs Antagonist - -
Conc range: > 1x10-3 M
cytosolic Mg2+ Click here for species-specific activity table Ligand is endogenous in the given species Hs Antagonist - -
mM range
dantrolene Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist - -
Channel Blockers
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
ruthenium red Click here for species-specific activity table Hs - - - - -

How to cite this page

Ryanodine receptors: RyR3. Last modified on 28/07/2017. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=749.