Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	0	4870	15q13.3-q14	RYR3	ryanodine receptor 3
Mouse	6	0	4888	2 E3-E4	Ryr3	ryanodine receptor 3
Rat	3	0	248	3q35	Ryr3	ryanodine receptor 3

Previous and Unofficial Names

ryanodine receptor 3 | calcium release channel isoform 3

Database Links
Alphafold	Q15413 (Hs), E9PW34 (Mm), Q9R273 (Rn)
ChEMBL Target	CHEMBL2062 (Hs)
Ensembl Gene	ENSG00000198838 (Hs), ENSMUSG00000057378 (Mm), ENSRNOG00000006645 (Rn)
Entrez Gene	6263 (Hs), 20192 (Mm), 170546 (Rn)
Human Protein Atlas	ENSG00000198838 (Hs)
KEGG Gene	hsa:6263 (Hs), mmu:20192 (Mm), rno:170546 (Rn)
OMIM	180903 (Hs)
Pharos	Q15413 (Hs)
UniProtKB	Q15413 (Hs), E9PW34 (Mm), Q9R273 (Rn)
Wikipedia	RYR3 (Hs)

Functional Characteristics
Ca2+: (P Ca/P K6) single-channel conductance: 140 pS (50 mM Ca2+), 777 pS (250 mM K+)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference caffeine Hs - - - - - ⤷ pharmacological; mM range cytosolic Ca2+ Hs - - - - - ⤷ endogenous; μM range cytosolic ATP Hs - - - - - ⤷ endogenous; mM range ryanodine Hs - - - - - ⤷ pharmacological; nM - μM range

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference cytosolic Ca2+ Hs Antagonist - - ⤷ Conc range: > 1x10-3 M cytosolic Mg2+ Hs Antagonist - - ⤷ mM range dantrolene Hs Antagonist - - ⤷

Channel Blockers
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference ruthenium red Hs - - - - - ⤷