Top ▲

ABCC4

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 782

Nomenclature: ABCC4

Abbreviated Name: MRP4

Systematic Nomenclature: ABCC4

Family: ABCC subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 14 1325 13q32.1 ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group)
Mouse - - Abcc4 ATP-binding cassette, sub-family C member 4
Rat - - Abcc4 ATP binding cassette subfamily C member 4
Previous and Unofficial Names Click here for help
Multidrug resistance-associated protein 4 | MOATB | MRP4 | multispecific organic anion transporter B | ATP-binding cassette protein C4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | ATP-binding cassette | ATP binding cassette subfamily C member 4
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
tenofovir Hs - - 1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
estradiol disulfate Small molecule or natural product Hs Inhibition 6.7 pIC50 2
pIC50 6.7 (IC50 2x10-7 M) [2]

References

Show »

1. Kalyesubula R, Perazella MA. (2011) Nephrotoxicity of HAART. AIDS Res Treat, 2011: 562790. [PMID:21860787]

2. Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD, Borst P. (2003) Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J, 371 (Pt 2): 361-7. [PMID:12523936]

Contributors

Show »

How to cite this page